基于分散网络化生产系统的车间生产管理模式及系统设计研究

基于分散网络化生产系统,针对我国中小型机械制造企业技术现状,提出了在基本上不改变现有车间基础设施的前提下,通过信息集成建立产品数据,财务和计算机辅助车间调度等管理子系统,以增强企业适应产品市场多变的能力;采用多品种,小批量生产方式,以满足产品生命周期缩短和２１世纪国际化大市场竞争的需求。     

计算机支持的协同项目设计模型

讨论了计算机支持的协同设计的工作环境及工作方式,提出了基于任务划分的协同设计的工作流结构,建立了协同工作空间以支持群体成员的项目设计,包括组建设计组、分解子任务、制定计划、执行计划、监督及修改计划等,描述了协同工作空间中的三级协同方式：计划协同、方案决策协同、设计图纸协同,并对协同工具———共享图板的实现进行了讨论．     

笔段型液晶显示器图形基元的计算机辅助设计系统

利用AutoLIST语言编程,对AutoCADR12系统进行二次开发,开发出绘制笔段型液晶显示器图形基元的计算机辅助设计系统"BJ"．使人机交工绘制基元图形的过程,转化为通过给定设计参数,自动生成基元图形的过程。节省了作图时间,降低了繁琐作图过程对菲林设计的干扰。     

DBMS软件产品数据库设计的实用策略

本文以“通用帐务处理软件数据库设计策略”为背景,对DBMS(Data Base Management System)软件产品数据库设计的方法和策略进行探讨。     

An application of factorial design to the development of fused silica capillary columns

Stationary phase crosslinking conditions for fused silica capillary columns were optimized with the use of a factorial design experiment. This experimental strategy was chosen because it provided for the determination of two-factor interactions. A predictive model was developed for the desired chromatographic performance parameters as a function of the variables of the crosslinking reaction. Confirmatory experiments proved the usefulness of the mathematical model which resulted in the production of capillary columns of superior performance with significant improvements in reproducibility.     

The optimization of silica gel synthesis from chemical bottle waste using response surface methodology

To reduce the amount of hazardous chemical bottle waste in the environment, we report the optimization research of silica extraction in chemical bottle waste into silica gel. Alkali fusion and sol–gel process were utilised to prepare silica gel effectively. The alkali fusion process was carried out by adding sodium hydroxide to produce sodium silicate. Afterwards, silica gel was prepared by the sol–gel method using hydrochloric acid. Box-Behnken Design (BBD) was applied to Optimisation factors the poptimiseactors affecting the silica recovery. The factors that optimised mass ratio, particle size, and temperature. The optimum recovery of silica gel was obtained by SiO₂: NaOH mass ratio of 1:3, the particle size of 63–74 µm, and a temperature of 800 °C. The purity of silica gel optimum is 63.74% characterised using X-ray fluorescence. The structure of silica gel is the appearance of amorphous peaks at 2θ 20-30° characterised using an x-ray diffractogram. The silica gel surface was characterises using scanning electron microscopy-energy dispersive x-ray. It showed an irregular surface and characteristic showed that silica gel had a radius of 15.74 nm and a specific surface area of 297.08 m².     

Factor Xa: Simulation studies with an eye to inhibitor design

Factor Xa is a serine protease which activates thrombin and plays a key regulatory role in the blood-coagulation cascade. Factor Xa is at the crossroads of the extrinsic and intrinsic pathways of coagulation and, hence, has become an important target for the design of anti-thrombotics (inhibitors). It is not known to be involved in other processes than hemostasis and its binding site is different to that of other serine proteases, thus facilitating selective inhibition. The design of high-affinity selective inhibitors of factor Xa requires knowledge of the structural and dynamical characteristics of its active site. The three-dimensional structure of factor Xa was resolved by X-ray crystallography and refined at 2.2 Å resolution by Padmanabhan and collaborators. In this article we present results from molecular dynamics simulations of the catalytic domain of factor Xa in aqueous solution. The simulations were performed to characterise the mobility and flexibility of the residues delimiting the unoccupied binding site of the enzyme, and to determine hydrogen bonding propensities (with protein and with solvent atoms) of those residues in the active site that could interact with a substrate or a potential inhibitor. The simulation data is aimed at facilitating the design of high-affinity selective inhibitors of factor Xa.     

Functionality map analysis of the active site cleft of human thrombin

Summary The Multiple Copy Simultaneous Search methodology has been used to construct functionality maps for an extended region of human thrombin, including the active site. This method allows the determination of energetically favorable positions and orientations for functional groups defined by the user on the three-dimensional surface of a protein. The positions of 10 functional group sites are compared with those of corresponding groups of four thrombin-inhibitor complexes. Many, but not all features, of known thrombin inhibitors are reproduced by the method. The results indicate that certain aspects of the binding modes of these inhibitors are not optimal. In addition, suggestions are made for improving binding by interaction with functional group sites on the thrombin surface that are not used by the thrombin inhibitors. Abbreviations: MCSS, multiple copy simultaneous search; PPACK, d-phenylalanyl-l-propyl-l-arginine chloromethane; NAPAP, N -(2-naphthylsulfonylglycyl)-d-para-amidinophenylalanylpiperidine; argatroban, (2R,4R)-4-methyl-1-[N -(3-methyl-1,2,3,4-tetrahydro-8-quinolinylsulfonyl)-l-arginyl]-2-piperidine carboxylic acid; rms, root mean square. The thrombin residues are numbered according to the chymotrypsin-based numbering by Bode et al. [8]. P1, P2, P3, etc., denote the peptide inhibitor residues on the amino-terminal side of the scissile peptide bond, and S1, S2, S3, etc., the corresponding subsites of thrombin     

凸轮-连杆组合机构设计系统

将计算机辅助设计技术、网络技术与机构设计相结合,以组合机构的尺寸综合理论为基础,以机构最小尺寸为优化目标,采用Java作为开发语言,应用模块化的面向对象的设计方法,研制开发了凸轮-连杆组合机构网上设计系统.     

基于min型表现外延的反馈外延外包络

相对于max型表现外延,给出min型表现外延的定义,利用min型表现外延构造了概念关于因素的min型反馈外延.研究了min型反馈外延与概念外延以及复杂因素min型反馈外延与简单因素min型反馈外延之间的关系,得到了与min型反馈外延相关的一些重要性质.定义了min型反馈外延外包络,给出一种从概念外延"内部"对概念外延进行逼近的方法.