固壁近旁Stokes流中粘性液滴的运动和变形

发展了一种模拟固壁近旁轴对称Stokes流中粘性液滴的运动和变形及直接计算固壁上应力的边界积分方法．用此方法对不同的液滴-固壁初始相对间距、粘度比、表面张力和浮力联合参数以及环境流动参数情况进行了数值实验．数值结果显示,由于环境流动和浮力的作用,随着时间的推进,液滴在轴向压缩,在径向拉伸．当环境流动的作用弱于浮力作用时,随着时间的推移,液滴上升并向上弯,固壁上由液滴运动所引起的应力不断减小．当环境流动的作用强于浮力作用时,随着时间的推移,液滴变得越来越扁．在这种情形,当大初始间距时,壁面上的应力随液滴的演变而增大;当小初始间距时,由环境流动、浮力及壁面对流动的较强作用的联合影响,此应力随液滴的演变而减小．由于液滴运动所引起的壁面应力的有效作用仅限于对称轴附近的一个小范围内,且此范围随液滴与固壁的初始间距增大而增大．应力的大小随初始间距增大而大为减小．表面张力对液滴变形有阻止作用．液滴粘性会减小液滴的变形和位置迁移．     

Okamoto model for necrosis and its expansions,CD38-cyclic ADP-ribose signal system for intracellular Ca2+ mobilization and Reg (Regenerating gene protein)-Reg receptor system for cell regeneration

In pancreatic islet cell culture models and animal models, we studied the molecular mechanisms involved in the development of insulin-dependent diabetes. The diabetogenic agents, alloxan and streptozotocin, caused DNA strand breaks, which in turn activated poly(ADP-ribose) polymerase/synthetase (PARP) to deplete NAD⁺, thereby inhibiting islet β-cell functions such as proinsulin synthesis and ultimately leading to β-cell necrosis. Radical scavengers protected against the formation of DNA strand breaks and inhibition of proinsulin synthesis. Inhibitors of PARP prevented the NAD⁺ depletion, inhibition of proinsulin synthesis and β-cell death. These findings led to the proposed unifying concept for β-cell damage and its prevention (the Okamoto model). The model met one proof with PARP knockout animals and was further extended by the discovery of cyclic ADP-ribose as the second messenger for Ca²⁺ mobilization in glucose-induced insulin secretion and by the identification of Reg (Regenerating gene) for β-cell regeneration. Physiological and pathological events found in pancreatic β-cells have been observed in other cells and tissues.     

Antioxidant behaviour of 2′‐hydroxy‐chalcones: a study of their electrochemical properties

The electrochemical behaviour of 13 chalcone analogues was systematically studied by means of cyclic voltammetry and chronoamperometry at a glassy carbon (GC), gold and platinum working electrodes using two different supporting electrolyte/solvent combinations. It was found that chalcone analogues can be easily oxidized at both GC and gold working electrodes, but not at a platinum electrode. Principal component analysis was further employed to reveal similarities/dissimilarities between oxidation potentials, chronoamperometric signals and ability of the compounds to scavenge the reactive oxygen species H₂O₂. The study reveals the inverse proportional relationship between the scavenging ability of H₂O₂, expressed as IC₅₀, and chronoamperometric signal at 800 mV using gold as working electrode. Copyright © 2012 John Wiley & Sons, Ltd.     

Homogeneous Cu–Fe supersaturated solid solutions prepared by severe plastic deformation

A Cu–Fe nanocomposite containing 50 nm thick iron filaments dispersed in a copper matrix was processed by torsion under high pressure at various strain rates and temperatures. The resulting nanostructures were characterized by transmission electron microscopy, atom probe tomography (APT) and Mössbauer spectrometry. It is shown that α-Fe filaments are dissolved during severe plastic deformation leading to the formation of a homogeneous supersaturated solid solution of about 12 at% Fe in fcc Cu. The dissolution rate is proportional to the total plastic strain but is not very sensitive to strain rate. Similar results were found for samples processed at liquid nitrogen temperature. APT data revealed asymmetric composition gradients resulting from deformation-induced intermixing. On the basis of these experimental data, the formation of the supersaturated solid solutions is discussed.     

Cyclic codes of length 2 m

In this paper explicit expressions ofm + 1 idempotents in the ring are given. Cyclic codes of length 2 ^m over the finite fieldF _q, of odd characteristic, are defined in terms of their generator polynomials. The exact minimum distance and the dimension of the codes are obtained.     

The Dirac Operator on Nilmanifolds and Collapsing Circle Bundles

We compute the spectrum of the Dirac operator on 3-dimensional Heisenberg manifolds. The behavior under collapse to the 2-torus is studied. Depending on the spin structure either all eigenvalues tend to ± or there are eigenvalues converging to those of the torus. This is shown to be true in general for collapsing circle bundles with totally geodesic fibers. Using the Hopf fibration we use this fact to compute the Dirac eigenvalues on complex projective space including the multiplicities.Finally, we show that there are 1-parameter families of Riemannian nilmanifolds such that the Laplacian on functions and the Dirac operator for certain spin structures have constant spectrum while the Laplacian on 1-forms and the Dirac operator for the other spin structures have nonconstant spectrum. The marked length spectrum is also constant for these families.     

形变量对MAE及BN的影响

研究了无取向硅钢Ｗ２３Ｇ，Ｗ１０，Ｗ１４和取向硅钢Ｑ８Ｇ４种材料在不同形变量下的磁声发射（ＭＡＥ）和巴克豪森噪音（ＢＮ），结果表明ＭＡＥ随形变量增大而减少，ＢＮ随形变量的增大而增大．测量了形变量为１０．４％的Ｗ１８和Ｗ２３Ｇ在１００，２００，３００，…，７００°Ｃ各退火１ｈ的ＭＡＥ与ＢＮ值．其中ＭＡＥ值随退火温度的升高逐渐增大，ＢＮ值在高于５００°Ｃ退火时明显下降．并对上述实验结果进行了详细讨论．     

Hypercrosslinked polystyrene: A polymer in a non‐classical physical state

Deformation and relaxation properties of hypercrosslinked polystyrene networks have been studied by thermomechanical method at a uniaxial compression using individual spherical beads of the polymer. The networks examined were prepared by postcrosslinking of highly swollen beads of a styrene‐0.3% DVB copolymer with 0.3–0.75 mole of monochlorodimethyl ether, which results in the introduction of 0.6–1.5 methylene bridges between each two polystyrene phenyl rings. The polymers obtained are shown to belong neither to typical glassy materials, nor to typical elastomers. Though no characteristic plateau of rubberlike elasticity was observed on the deformation curves of the beads, the polymers exhibit two fundamentally important features of the rubberlike state: The deformations are large (up to 30–40% of the initial diameter) and reversible. Relaxation of residual deformations, however, requires prolonged heating of the sample, or a cycle of swelling and drying. The deformation can start in the temperature range from −70 to +150°C depending on pressure applied. The crosslinking degree in the range from 40–100% and higher does not affect noticeably the behavior of the hypercrosslinked polystyrene. Nature of the high mobility of the hypercrosslinked network is discussed. © 1999 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 37: 2324–2333, 1999     

Constraining Cyclic Peptides To Mimic Protein Structure Motifs

Many proteins exert their biological activities through small exposed surface regions called epitopes that are folded peptides of well‐defined three‐dimensional structures. Short synthetic peptide sequences corresponding to these bioactive protein surfaces do not form thermodynamically stable protein‐like structures in water. However, short peptides can be induced to fold into protein‐like bioactive conformations (strands, helices, turns) by cyclization, in conjunction with the use of other molecular constraints, that helps to fine‐tune three‐dimensional structure. Such constrained cyclic peptides can have protein‐like biological activities and potencies, enabling their uses as biological probes and leads to therapeutics, diagnostics and vaccines. This Review highlights examples of cyclic peptides that mimic three‐dimensional structures of strand, turn or helical segments of peptides and proteins, and identifies some additional restraints incorporated into natural product cyclic peptides and synthetic macrocyclic peptidomimetics that refine peptide structure and confer biological properties.