Stereocontrolled Synthesis of Oligo(nucleoside phosphorothioate)s

Encouraging results obtained for modulation of gene expression by antisense oligonucleotides and their analogues have kindled hopes for a new generation of therapeutics against viral infections, cancer, and many other diseases. Among such analogues, oligo(nucleoside phosphorothioate)s (Oligo-S) have generally shown the highest efficacy in inhibiting the biosynthesis of “unwanted” proteins. The first clinical trials of antisense agents are now in progress using Oligo-S against genital warts and acute myeloid leukemia, and tests of Oligo-S against AIDS should follow soon. Nevertheless, their mechanism of action, internalization, cellular trafficking, subcellular localization, and interaction with cellular proteins is still poorly understood. It is assumed a priori that application involves rapid and efficient molecular recognition of target RNA by Oligo-S; however, the effects of the chirality of Oligo-S have so far been unappreciated, because Oligo-S has not yet been synthesized with stereocontrol. Indeed, the diastereomeric composition of Oligo-S has never been determined, primarily because of the lack of appropriate analytical methods. Since each of the diastereomers is a stereochemically unique chemical entity, questions arise as to which diastereomer is responsible for an observed biological response, including positive (curative) or possibly negative (toxic) side effects. In this review we intend provide a perhaps somewhat speculative assessment of the problems associated with the stereo-controlled synthesis of Oligo-S and to discuss the state-of-the-art in this field including strategies that may lead to Oligo-S of predetermined chirality. This article is not intended to discourage researchers from further studies of dia-steromeric mixtures of Oligo-S as potential pharmaceuticals. Throughout the history of medicinal chemistry numerous useful medicines were discovered, developed, and employed without the detailed knowledge of their structure. Indeed, the composition of the vaccines discovered by Pasteur is a subject of vigorous study still today.     

从能源产业发展和人才需求浅谈“能源化学”新工科改造

Based on building emerging engineering education of "energy chemistry", we investigated the state key petro-chemical enterprises according to the industrial development and the demand of professional talents. The research report summarizes, analyzes and discusses the current priority development fields of industry, the talent training status, curriculum structure and education program of the chemistry and chemical engineering in universities. The ideas on emerging engineering education of "energy chemistry" have been proposed, and it will be beneficial to building a novel education program for talents training, which integrates the principle of chemistry, energy conversion and information science, etc.     

光催化研究与发展的文献计量分析

对ＣＡ１９６１－１９９６年期间卷双期号期刊中收录的与光催化有关的各种文献进行了详细的统计,结果表明,光催化研究正处于快速的发展期,以消除环境污染为目的应用研究是该快速发展期中的主题,日本,美国,俄罗斯和中国发表文献量居世界前４位。     

试论我国矿业企业的技术创新

知识经济时代是以创新为重要特征的。创新是知识经济的核心。也是提高矿业企业市场竞争力、促进矿业企业生产发展的动力。目前我国矿业企业技术创新能力不强，技术成果转化率低下，各种制度因素、经济因素和环境因素制约着企业的创新和发展。从我国矿业企业技术创新的现状分析入手，提出了提高企业技术创新能力的对策。     

论技术规范产生的必要性

简要介绍了技术规范的含义，从技术实践需要理论指导、科学规范在技术领域的局限性和技术问题的存在三方面探讨了技术规范产生的论要性。     

茶多酚的研究进展及应用前景

茶多酚是茶的特有成分。它具有防治心血管疾病、防癌抗癌、抗衰老、抗辐射等方面的保健功能。本文就茶多酚在这些领域的研究进展及其应用前景作了综述。     

知识产权的国际化与我国的对策

20世纪以来,知识产权走上国际化的道路,保护的客体范围不断扩大,众多的保护知识产权的国际组织成立,双重保护体系基本形成.我国基于改革开放、市场经济建设及国际知识产权保护的推动,作为知识产权三大支柱的商标法、专利法、著作权法先后实施,随着知识产权国际化的趋势,我国知识产权立法不断地修改、完善,知识产权行政执法和司法的保护力度不断加大,使得我国知识产权保护制度与国际上的做法接轨.     

浅析国内旅游市场需求新趋势

随着社会经济增长及旅游活动的普及．旅游市场需求发生着快速变化。本文分析了旅游市场发展现状及市场需求所呈现的新趋势，并就旅游经营对策提出了几点建议。     

城市生态系统平衡在沈阳城市发展中的作用

阐述了城市生态系统内涵、特征．在参考国内外相关资料基础上指出：城市生态系统理论是把城市当作一个系统来研究，用生态学和系统论的思想、方法来分析和研究城市问题，指导城市规划、建设和发展的理论体系，对于沈阳的生态建设和城市可持续发展具有重要的指导意义．分析了城市生态系统平衡在沈阳城市发展中的作用，并有针对性地探讨了保持沈阳城市生态系统平衡的对策．     

高校科研管理系统的设计与实现

本文介绍了用Delphi语言与SQL技术相结合开发高校科研管理系统的意义及实现方法,该系统具有项目管理、成果管理、论文管理、专著管理、人员管理及经费管理等多种业务功能,适合大专院校和科研管理部门使用,有利于提高工作效率,促进科研管理的水平的进一步提高.