C／S结构下客户端应用程序自动升级的方法研究

用C／S结构开发的网络软件，要解决的主要问题之一就是客户端的自动升级，只有完成了这一功能，才能使开发的网络软件能及时更新与完善。文章介绍了一种在客户／服务器结构下客户端软件自动升级的实现方法，并基于Delphi探讨了其中的部分关键技术。     

多视点视频编码框架及关键技术

多视点视频编码(MVC)技术是今后视频领域研究的热点之一,也是立体视频编码技术的进一步延伸.在给出多视点视频概念之后,详细描述了MVC框架.接着详细介绍了MVC预测编码、DMVC边信息生成、MVC码率控制等多项关键技术.最后,给出了MVC标准化过程及相关国际标准.     

均匀磁场激励磁感应成像滤波反投影算法

通过亥姆霍兹线圈在中心区域建立正弦均匀的激励磁场,磁场方向近似直线,有助于简化逆问题的复杂度.建立了8通道磁感应测量系统仿真模型,采用滤波反投影算法重构出电导率分布.在滤波反投影算法中,首先用线性插值补充检测数据,然后用Hamming滤波器对数据进行滤波,同时加入窗口滤波器减少了涡流磁场发散对周围线圈的影响.加入不同噪声比的噪声干扰,测试了算法对噪声的抑制能力,实验结果表明该模型下运用反投影滤波算法可以重构出电导率的分布.     

碳酸镉饱和溶液作标准用便携式AAS测定镉的研究

以CdCO3固体溶于煮沸冷却的去离子水中配制成饱和溶液,将该饱和溶液稀释成标准溶液系列用于便携式钨丝电热原子吸收光谱仪野外实时与在线分析环境水样中痕微量镉。经测定在25℃该饱和溶液中镉的浓度为272μg.L-1,与理论计算值279μg.L-1有很好的吻合。实验优化了相关的仪器条件和实验条件,在最优的条件下该方法的线性相关系数为0.9948,检出限为0.08μg.L-1。通过检测分析环境中的水样验证了该方法是可行的。     

多肽序列优化降低c-Src蛋白靶向药物的毒性风险

避免c-Src蛋白的多肽类拮抗剂与多个蛋白发生混杂性结合,对于降低抗癌药物的毒性风险具有重要作用。本研究运用生物信息学方法对氨基酸序列进行优化设计,旨在减少混杂性结合的发生。本研究综合利用各种多肽数据库和生物信息学工具,首先总结了多肽分子与多个蛋白SH3结构域之间潜在的混杂性结合,并发现了其中的内在规律。随后,根据所发现的规律,对多肽的氨基酸序列进行针对性的优化设计。结果表明,大多数多肽在经过优化后,所结合的c-Src以外的蛋白数量都有所下降,从而显著提高了多肽与c-Src蛋白之间结合的特异性(P0.05),并降低了其潜在的毒性风险。本研究所取得的结果将为设计具有高度特异性和低毒性的靶向性多肽药物提供参考。     

微小型磁电发电机输出性能计算方法研究

盘式微小型磁电发电机具有功率密度大、轴向尺寸小、可长期储存等诸多优点,用于引信电源有着良好的前景.磁电发电机输出性能受线圈参数与磁路结构共同影响,难于得到解析模型.为从理论上计算磁电发电机的输出性能,论文采用解析推导与仿真分析相结合的方法获得磁电发电机的输出电压,并根据计算结果设计并加工了实验样机.磁电发电机的输出性能实验结果表明,理论分析结果与实验结果误差仅为0.2%,证实了本文提出的计算方法的合理性.     

某MPV正面碰撞乘员侧胸部损伤优化

为了提高某MPV的正面碰撞安全性能,基于该车型正面碰撞试验工况,建立了乘员侧的MADYMO仿真模型。根据正面碰撞试验获得的假人损伤数据,进行了该模型有效性的验证。并依据2015版中国新车评价规程(C-NCAP)管理规定和约束系统能量管理技术,从安全带限力等级、预紧器、安全气囊气袋刚度三个方面对乘员胸部进行了优化,同时进行了试验验证。结果表明,这三个方面可以有效地降低假人的伤害,提高了该车型乘员侧在正面碰撞工况下的得分。     

Rotamer optimization for protein design through MAP estimation and problem‐size reduction

The search for the global minimum energy conformation (GMEC) of protein side chains is an important computational challenge in protein structure prediction and design. Using rotamer models, the problem is formulated as a NP‐hard optimization problem. Dead‐end elimination (DEE) methods combined with systematic A* search (DEE/A*) has proven useful, but may not be strong enough as we attempt to solve protein design problems where a large number of similar rotamers is eligible and the network of interactions between residues is dense. In this work, we present an exact solution method, named BroMAP (branch‐and‐bound rotamer optimization using MAP estimation), for such protein design problems. The design goal of BroMAP is to be able to expand smaller search trees than conventional branch‐and‐bound methods while performing only a moderate amount of computation in each node, thereby reducing the total running time. To achieve that, BroMAP attempts reduction of the problem size within each node through DEE and elimination by lower bounds from approximate maximum‐a‐posteriori (MAP) estimation. The lower bounds are also exploited in branching and subproblem selection for fast discovery of strong upper bounds. Our computational results show that BroMAP tends to be faster than DEE/A* for large protein design cases. BroMAP also solved cases that were not solved by DEE/A* within the maximum allowed time, and did not incur significant disadvantage for cases where DEE/A* performed well. Therefore, BroMAP is particularly applicable to large protein design problems where DEE/A* struggles and can also substitute for DEE/A* in general GMEC search. © 2009 Wiley Periodicals, Inc. J Comput Chem, 2009     

Atomic absorption spectrometric determination of trace tellurium after hydride trapping on platinum-coated tungsten coil

In this work, a sensitive and simple method for the determination of tellurium was developed by hyphenation of electrically heated quartz tube atomic absorption spectrometry and tellurium hydride trapping on platinum-coated tungsten coil. With a mixture of Ar and H₂, tellurium hydride was transported to tungsten coil for trapping at 390 °C and releasing at 1200 °C. A limit of detection (LOD, 3σ) of 0.08 ng mL^{− 1} was obtained with 1 min trapping (1.5 mL sampling volume), and enhancement factor was 28 compared to conventional hydride generation atomic absorption spectrometry. The LOD was better or at least comparable to literature levels involving on-line trapping and some other sophisticated instrumental method such as graphite furnace atomic absorption spectrometry (GF-AAS) and inductively coupled plasma mass spectrometry (ICP-MS), and it can be further lowered down to 0.03 ng mL^{− 1} by increasing the trapping time to 4 min. The platinum coating was stable for 300 firings without sensitivity loss. Interference and its alleviation were studied in detail. The proposed method was applied to the determination of tellurium in several geological standard reference materials, and the results were found in good agreement with the certified values.     

p拉普拉斯Dirichlet问题的非平凡解

研究一类特殊的p拉普拉斯Dirichlet问题.当非线性项在正无穷远处是超线性而在负无穷远处是渐近线性情形,使用极小极大方法建立非平凡解的存在性结果.