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31.
胡剑虹 《南京理工大学学报(自然科学版)》1998,22(5):448-450
扬州信里居住小区工程是国家“九五”重点加强项目“3000m^3定向结构板成套设备及产业化”的应用性研究内容之一。该文从建筑设计,室内装饰,材料选择及构造等方面,讨论了定向反在建筑及室内的运用实践。它不仅在性能上,结构上而且在经济上都有很好的应用前景,为高质量的居住空间的合理开发提供了一条有效途径。 相似文献
32.
高层建筑侧向刚度计算的分域样条虚边界元法 总被引:6,自引:2,他引:4
采用弹性力学平面问题的分域样条虚边界元法导出了高层建筑平面抗侧力结构的侧向刚度矩阵.该方法只需要输入少量数据,便可准确迅速地计算出平面结构的侧向刚度矩阵,据此即可对整个结构进行静力和动力分析. 相似文献
33.
陈加猛 《华南理工大学学报(自然科学版)》1998,26(3):32-38
按照常规的方法,将筒中筒结构的外框筒连续化为具有弯曲变形和剪切变形,同时考虑其剪力滞后影响的等效实腹筒体.内筒只考虑其弯曲变形,内外筒的变形是协调的.然后用虚拟水平分布荷载来模拟由竖向荷载产生的P_Δ效应,推导出结构的整体稳定微分方程,用Galerkin法求解方程并获得整体结构的最小临界荷载. 相似文献
34.
通过将剪切型建筑结构的固有频率调离场地的卓越频率区域,提出一种抗共振抗震设计方法。数值算例说明该方法是很有效的。 相似文献
35.
Under fluoride activation, the vinyl fluorine of perfluoroketene dithioacetal may be substituted by silylated nucleophiles. Using silyl alkynes, a formal transition metal free sila-Sonogashira cross-coupling reaction occurred. The resulting enynes were hydrolyzed giving new polyfunctional trifluoromethyl building blocks. 相似文献
36.
Bei-sheng Kang Mao-chun Hong Ting-bin Wen Han-qin Liu Jia-xi Lu 《Journal of Cluster Science》1995,6(3):379-401
Simple fragments of transition metal 1,2-bidentate thiolates, the so-called building blocks of the general compositions ML3, ML2, ML, M(O)L2, ML2L, MLL, etc. have been proposed to constitute the di-, tri- and tetranuclear complexes concerned in this review. Structureal regularities and characteristics have been discussed and summarized according to the thiolato ligands edt and pdt, bdt and tdt, mp, and mpo, and mpp, respectively.Abbreviations H2mpo
o-mercaptophenol
- Hmpo
2-mercaptopyridine-N-oxide
- R2dtc
N,N-dialkyldithiocarbamate
- Haet
2-aminoethanethiol
- H2bdt
o-benzenedithiol
- H2pdt
1,2-propanedithiol
- H2tdt
toluene-3,4-dithiol
- Hmpp-mppH
bis-(3-hydroxy-2-pyridyl)disulfide
- Hmp-mpH
bis-(2-oxyphenyl)disulfide
- H2edt
1,2-ethanedithiol
- dppe
1,2-bis(diphenylphosphino)ethane
- H2tedt
3,4,5,6-tetrachlorobenzene-1,2-dithiol
- H2tpdt
3-thiapentane-1,5-dithiol
- H2mnt
maleonitriledithiol
- Him
imidazole
- Bz
benzyl
- py
pyridine 相似文献
37.
Lumbierres M Palomo JM Kragol G Roehrs S Müller O Waldmann H 《Chemistry (Weinheim an der Bergstrasse, Germany)》2005,11(24):7405-7415
A new flexible and efficient methodology for the solid-phase synthesis of lipidated peptides has been developed. The approach is based on the use of previously synthesized building blocks and overcomes the limitations of previously reported methods, since long doubly lipidated peptides can be synthesized by using this route. Furthermore, it was thus possible to prepare a large number of N- and H-Ras peptides bearing a wide range of reporter and/or linking groups--efficient tools for the investigation of biological processes. In terms of efficiency and flexibility this solid-phase method is superior to the solution-phase synthesis. It gives pure peptides in multimilligram amounts within a much shorter time and with superior overall yield. 相似文献
38.
Firoz A. Jaipuri 《Tetrahedron letters》2004,45(21):4149-4152
A versatile route for the modular synthesis of (R)-3-hydroxyalkanoic acids, constituents of the naturally biodegradable poly(3-hydroxyalkanoate) polymers, and its application to the synthesis of (R)-3-hydroxydecanoic acid is described. Key steps include a microwave-assisted catalytic transfer hydrogenation and a facile microwave-assisted hydrolysis of an N-methoxy-N-methyl (Weinreb) amide, which enhances the practicality of this protecting group for carboxylic acids. 相似文献
39.
Luc M. H. Koymans Nico P. E. Vermeulen Allard Baarslag Gabriëlle M. Donné-Op den Kelder 《Journal of computer-aided molecular design》1993,7(3):281-289
Summary A homology model building study of cytochrome P450 2D6 has been carried out based on the crystal structure of cytochrome P450 101. The primary sequences of P450 101 and P450 2D6 were aligned by making use of an automated alignment procedure. This alignment was adjusted manually by matching -helices (C, D, G, I, J, K and L) and -sheets (3/4) of P450 101 that are proposed to be conserved in membrane-bound P450s (Ouzounis and Melvin [Eur. J. Biochem., 198 (1991) 307]) to the corresponding regions in the primary amino acid sequence of P450 2D6. Furthermore, -helices B, B and F were found to be conserved in P450 2D6. No significant homology between the remaining regions of P450 101 and P450 2D6 could be found and these regions were therefore deleted. A 3D model of P450 2D6 was constructed by copying the coordinates of the residues from the crystal structure of P450 101 to the corresponding residues in P450 2D6. The regions without a significant homology with P450 101 were not incorporated into the model. After energy-minimization of the resulting 3D model of P450 2D6, possible active site residues were identified by fitting the substrates debrisoquine and dextrometorphan into the proposed active site. Both substrates could be positioned into a planar pocket near the heme region formed by residues Val370, Pro371, Leu372, Trp316, and part of the oxygen binding site of P450 2D6. Furthermore, the carboxylate group of either Asp100 or Asp301 was identified as a possible candidate for the proposed interaction with basic nitrogen atom(s) of the substrates. These findings are in accordance with a recently published predictive model for substrates of P450 2D6 [Koymans et al., Chem. Res. Toxicol., 5 (1992) 211]. 相似文献
40.
综述了近年来利用一些新型的含氟砌块,通过它们的环加成反应来高效地合成 含氟杂环化合物的研究,其中包括以下两个部分:(1)用1,3—偶极环加成反应合 成五元含氟杂环化合物;(2)用杂原于Diels-Alder反应合成六元含氟杂环化合物. 相似文献