植物细胞培养实验在细胞工程实验教学中的应用

为提高细胞工程实验教学的效果,培养学生的实验操作能力和解决问题能力,探索了适合于实验教学的具体化和可操作的植物细胞培养方案.大叶黄杨(Euonymus japonicus)和紫花地丁(Viola philippica)可作为植物细胞培养的理想实验材料;诱导愈伤组织的最适培养基为基本培养基+2,4-二氯苯氧乙酸2 mg/L+6-苄氨基腺嘌呤0.4 mg/L.     

电化教学在加强生物工程学教学中的作用

简要地介绍了电化教学在加强生物工程教学中简化教学过程，增加课程的信息传递量；拓展教学的浓度和广度，开展形象化教学等方面的作用。     

基于偏序集的生物科技企业财务绩效评价研究

针对传统财务绩效评价方法中指标权重赋值争议问题,基于偏序集理论提出企业财务绩效评价模型,对22家生物科技上市企业财务绩效进行评价。研究表明：参与评价的样本企业分为财务绩效水平较高和较差两个层级,进一步再通过非参数检验发现不同层级的企业在盈利能力、营运能力和成长能力方面存在显著差异,而在偿债能力方面差异并不明显。本文研究成果,既有利于生物科技企业明确竞争地位,寻找差距,不断提高企业的财务绩效水平,也为完善企业财务绩效评价方法提供有益的借鉴和启示。     

DARPA生物科技项目部署解析

 2014年,美国国防高级研究计划局（DARPA）宣布成立生物技术办公室（BTO）,聚焦军人能力保持恢复与增强、生物系统的工程化应用、生物复杂性的规模化应用3个研究方向。在研项目由BTO成立时的23项发展到现在的31项,经费投入更为理性,研究重点更为聚焦。在文献调研基础上,利用专家咨询、综合分析、综合归纳等方法,解析了DARPA2016年以来的生物技术项目部署情况,表明其特点为：重点关注脑机接口领域,聚焦人机高效协同技术;着眼应对大规模流行性传染病暴发,重点研究快速诊断预防技术;高度关注生物安全威胁,重点研究安全防护对策;加快部署合成生物学研究,重点研究生物系统工程技术等。     

论生物技术实验教学改革的必要性

生物工程学科和产业发展的特点决定了生物技术实验技能是生物工程人才培养的关键环节;针对生物工程专业现行生物技术实验教学的薄弱之处,提出了改进和加强实验技能培养的具体建议。     

《生物技术综合实验》独立设课教学改革实践简

通过《生物技术综合实验》课程的独立设课实践,探讨了基于独立设课的教学实验基地建设,以及合理设置教学内容、优化教学方法和考核措施的教学改革.文章认为,该课程的独立设课教学方式的实施,有利于促进本科生提高实验技能以及创新能力的培养.     

Production of Valuable Drugs from Plant Cells Immobilized by Hybrid Sol-Gel SiO2

Catharantus roseus cells are supported on a polyester fiber mat and encapsulated by a porous layer of SiO2 modified by Si–CH3 and Si–H bonds. This layer is obtained by reaction of Si-alkoxides in the gas phase with H2O adsorbed on the cell surface or with exposed –OH groups of cellulosic cell membrane. Viability and alkaloid production of cells are maintained after encapsulation. An experimental reactor allows study of secondary metabolite productivity, which is increased by two orders of magnitude with respect to that of free cells.Sucrose consumption kinetics are also studied and related to the viability of encapsulated cells.     

Production Options for Psilocybin: Making of the Magic

The fungal genus Psilocybe and other genera comprise numerous mushroom species that biosynthesize psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine). It represents the prodrug to its dephosphorylated psychotropic analogue, psilocin. The colloquial term “magic mushrooms” for these fungi alludes to their hallucinogenic effects and to their use as recreational drugs. However, clinical trials have recognized psilocybin as a valuable candidate to be developed into a medication against depression and anxiety. We here highlight its recently elucidated biosynthesis, the concurrently developed concept of enzymatic in vitro and heterologous in vivo production, along with previous synthetic routes. The prospect of psilocybin as a promising therapeutic may entail an increased demand, which can be met by biotechnological production. Therefore, we also briefly touch on psilocybin's therapeutic relevance and pharmacology.     

Optimized method for the recombinant production of a sea anemone’s peptide

The production of the analgesic peptide HCRG21 for medical use is restricted by a number of limitations in the technology. The optimal biotechnological method scalable to industrial has been developed based on the production of a fusion protein containing a special leader, His-tag, and Smt3 sequence upstream in the peptide sequence. The resulting peptide shared its inhibitory activity to TRPV1 ion channel identical to the published early.     

长周期光栅生物传感器研究进展

长周期光纤光栅是对周围环境比较敏感的一种无源光学器件,由于其具有无后向反射、对折射率灵敏度高、体积小、易于集成化、不受电磁干扰、耐酸碱腐蚀、不需要参比电极等诸多特点,在折射率传感领域备受关注。自从2000年Bentley研究组第一次将长周期光纤光栅用于抗原的检测以来,经过十余年的发展,长周期光栅在生物物质的检测方面取得了很大的进展,已被用于抗原抗体、细菌病毒、蛋白质、DNA、酶及核酸等诸多生物物质的检测。本文对长周期光纤光栅近年来在生物传感领域的研究进展和应用进行了总结和评述,并对长周期光纤光栅在生物物质检测方面的未来发展趋势做了展望。