全文获取类型
收费全文 | 4289篇 |
免费 | 288篇 |
国内免费 | 629篇 |
专业分类
化学 | 2231篇 |
晶体学 | 13篇 |
力学 | 91篇 |
综合类 | 48篇 |
数学 | 132篇 |
物理学 | 463篇 |
综合类 | 2228篇 |
出版年
2024年 | 14篇 |
2023年 | 51篇 |
2022年 | 149篇 |
2021年 | 149篇 |
2020年 | 148篇 |
2019年 | 107篇 |
2018年 | 88篇 |
2017年 | 114篇 |
2016年 | 115篇 |
2015年 | 134篇 |
2014年 | 195篇 |
2013年 | 274篇 |
2012年 | 240篇 |
2011年 | 278篇 |
2010年 | 173篇 |
2009年 | 221篇 |
2008年 | 241篇 |
2007年 | 312篇 |
2006年 | 303篇 |
2005年 | 292篇 |
2004年 | 226篇 |
2003年 | 234篇 |
2002年 | 178篇 |
2001年 | 149篇 |
2000年 | 128篇 |
1999年 | 100篇 |
1998年 | 76篇 |
1997年 | 73篇 |
1996年 | 74篇 |
1995年 | 58篇 |
1994年 | 49篇 |
1993年 | 36篇 |
1992年 | 42篇 |
1991年 | 34篇 |
1990年 | 33篇 |
1989年 | 26篇 |
1988年 | 29篇 |
1987年 | 19篇 |
1986年 | 12篇 |
1985年 | 8篇 |
1984年 | 11篇 |
1983年 | 1篇 |
1982年 | 6篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1979年 | 3篇 |
排序方式: 共有5206条查询结果,搜索用时 15 毫秒
101.
合成了β-芳氧基丙酸芳酯及β-芳氧基丙酰芳胺等17种化合物,经IR,UV,HNMR和元素分析确定了它们的结构,并对它们的生物活性进行了初步考察。 相似文献
102.
To investigate the disposition of unbound cocaine in the rat blood, brain and bile, we demonstrate an in vivo multiple sampling microdialysis system coupled with liquid chromatography for cocaine assay and verified by tandem mass spectrometry. Three microdialysis probes were concurrently inserted into the jugular vein, bile duct and brain striatum of each anesthetized rat. After a period of 2 h post-surgical stabilization, cocaine (10 mg kg(-1)) was administered through the femoral vein. Separation of unbound cocaine from various biological fluids was applied to a reversed-phase C(18) column (250 x 4.6 mm I.D., 5 microm). The mobile phase consisted of acetonitrile--10 mm potassium dihydrogen phosphate buffer (25:75, v/v, pH 4.0) and 0.8% diethylamine at a flow rate of 1 mL min(-1). The UV detector wavelength was set at 235 nm. The results indicate that cocaine penetrates the blood--brain barrier with a rapid distribution. However, unbound cocaine in the bile dialysate was not detectable in the UV detection. We therefore use LC--tandem mass spectrometry to detect the bile fluid after cocaine administration (3 mg kg(-1), i.v.). The results indicate that cocaine goes through hepatobiliary excretion. 相似文献
103.
Rigid-rod aromatic polyimdies having polydimethylsiloxane side chains were prepared for the purpose of dispersing rigid-rod molecules in silicone matrices for molecular reinforcement. The polyimides were obtained by imidizing the polyamide-acids bearing the side chains either thermally or chemically, which were synthesized by reacting 4,4′-diaminobiphenyl-terminated polysiloxane macromonomers with pyromellitic dianhydride in THF. The polyamide-acid films obtained by removing the solvent were soluble in THF, but the polyimides were insoluble in any common solvent. The polyimides showed no melting transition below 350°C on DSC analysis, at which temperature the side chain started decomposing. Although all the polyimides were anisotropic as observed by a polarizing microscope, x-ray diffraction analysis suggested the presence of only limited chain organization. Blends with linear polydimethylsiloxanes were prepared by casting the THF solution containing the polyamide-acid and the polydimethylsiloxane, followed by solvent evaporation and thermal imidization. With relatively longer side chains, the polyimides were proved to be compatibilized with polydimethylsiloxanes. © 1994 John Wiley & Sons, Inc. 相似文献
104.
共合成了13个未见文献报道的三烃基锡肟衍生物,测定了它们的^1h,(^13C,^119Sn)NMR,IR和MS。结果表明此类化合物为四配位锡单体结构,生物活性测定结果表明部分化合物同时兼有杀菌、杀螨、除草多种活性。 相似文献
105.
106.
Laurent Griffe Dr. Mary Poupot Dr. Patrice Marchand Dr. Alexandrine Maraval Dr. Cédric‐Olivier Turrin Dr. Olivier Rolland Pascal Métivier Dr. Gérard Bacquet Dr. Jean‐Jacques Fournié Dr. Anne‐Marie Caminade Dr. Rémy Poupot Dr. Jean‐Pierre Majoral Dr. 《Angewandte Chemie (International ed. in English)》2007,46(14):2334-2334
107.
108.
Excipient compatibility of a new chemical entity was assessed using an isothermal microcalorimeter. Mixtures of an active
pharmaceutical ingredient with a primary amine group and excipients were prepared in a 1:1 ratio and compatibility monitored
by exposing to 50, 60 and 70°C in presence of 200 mL of water. The new chemical entity, a primary amine, reacted with reducing
sugars such as lactose and resulted in a brown discoloration. This reaction is the Maillard type condensation reaction between
amines and reducing sugars. The rate of reaction was dependent on the temperature with rapid degradation at higher temperatures.
No other incompatibility was apparent between the primary amine and other excipients
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
109.
A new phosphorylcholine, (6-hydroxy) hexyl-2-(trimethylammonio) ethyl phosphate (HTEP), was synthesized andcharasterized. Segmented polyurethane (SPU) containing phosphorylcholine structure was synthesized based ondiphenylmethane diisocyanate (MDI), soft segment polytetramethylene glycol (PTMG) and HTEP, with 1,4-butanediol (BD)as a chain extender. The existence of phosphorylcholine structure on the surface of SPU was revealed by attenuated totalreflectance Fourier transform infrard spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS) and water contactangle measurements. The blood compatibilities of the polymers were evaluated by hemolytic testing and a platelet-richplasma (PRP) adhesion experiment, which was viewed by scanning electron microscopy (SEM) with polyurethane as areference. The novel segmented polyurethane containing phosphorylcholine structure showed improved blood compatibility. 相似文献
110.
Sebastian G. Spain Matthew I. Gibson Neil R. Cameron 《Journal of polymer science. Part A, Polymer chemistry》2007,45(11):2059-2072
Glycopolymers are receiving increasing interest due to their application in areas, such as glycomics, medicine, biotechnology, sensors, and separation science. Consequently, new methods for their synthesis are constantly being developed, with an increasing emphasis on the preparation of well-defined polymers and on the production of complex macromolecular architectures such as stars. This review covers recent developments in the synthesis of glycopolymers, with a particular emphasis on (i) the use of controlled radical polymerization to prepare well-defined glycopolymers from unprotected monomers and (ii) postpolymerization modification strategies using reactive polymer precursors (including “click” reactions). Recent work on the production of glycosylated polypeptides, which are under investigation as mimics of naturally occurring glycoproteins, is also included. The authors offer some suggestions as to future developments and remaining challenges in this topical area of polymer chemistry. © 2007 Wiley Periodicals, Inc. J Polym Sci PartA: Polym Chem45: 2059–2072, 2007 相似文献