脑对双耳听觉信息整合的神经机制

综述近60 a来有关脑对双耳听觉信息整合的神经机制的研究进展.首先介绍了脑处理双耳信息的神经解剖学基础，双耳神经元的分类及其生理特性，以及双耳神经元在听觉系统的拓扑学分布研究；然后对脑处理双耳听觉信息研究的热点领域进行了重点探讨，综述了上橄榄复合体、下丘和听皮层双耳神经元对双耳时间差和双耳强度差的编码方式，以及脑通过对这些参数的编码来分析声源方位的神经生理学研究进展；最后对该领域未来研究方向作展望.     

Carrier polymers for cisplatin-type anticancer drug models

Following a brief discussion of the concept of polymer–drug conjugation and the use of platinum drugs in cancer therapy, the paper presents recent results in the synthesis of water-soluble polymeric carriers designed for the binding of antineoplastic coordination compounds of the cisplatin type. The target polymers, specifically, are linear aliphatic polyamides comprising the ethylenediamine ligand system in the main chain as the potential metal binding site. With solubility in aqueous media a key requirement for intravenously injectable conjugates, the polymers also contain hydrosolubilizing oligo(ethylene oxide) units in the chain, which serve the additional purpose of imparting resistance to serum protein binding and capture by the reticuloendothelial system. The synthesis methods include interfacial polymerization, high-temperature solution polycondensation in polyphosphoric acid and Michael addition polymerization, with 1,2-bis(2-aminoethylamino)ethane and 1,2-bis(3-aminopropylamino)ethane used as the amine comonomers providing the ethylenediamine ligand segment. The target polymers, crudely fractionated by dialysis in 25,000 molecular-mass cult-off tubing, are isolated by freeze-drying as water-soluble solids possessing inherent viscosities of 10–20 ml/g. A selected carrier polymer is converted to the corresponding water-soluble cis-diaminedichloroplatinum(II) conjugate by treatment with tetrachloroplatinate(II) anion in aqueous solution.     

运用小波变换实现听觉诱发电位的单次提取

论述了运用小波变换进行听觉诱发电位单次提取的原理,方法和实验分析。结果表明,对单次试验信号,经小波变换及相关分析后,可从带自发脑电干扰的信号中提取诱发电位信号。小波变换分析与传统的叠加平均方法相比,可减少试验次数,缩短检测周期。     

基于MRI和深度学习的桥小脑角区脑膜瘤与听神经瘤分类算法研究

桥小脑角区脑膜瘤与听神经瘤是两种常见的脑部肿瘤,它们的临床表现和影像学表现极为相似,在临床诊断时极易发生误诊．将影像数据与深度学习方法相结合,建立脑膜瘤与听神经瘤的判别模型,可以为两种脑肿瘤的及时准确诊断提供重要手段．本文采集了307名脑肿瘤患者的T₁W-SE序列图像,通过对原始图像进行限制对比度自适应直方图均衡化（Contrast Limited Adaptive Histogram Equalization,CLAHE）等预处理,提升数据集图像质量,再经过建立的三维卷积神经网络（3-Dimensional Convolutional Neural Network,3D CNN）深度学习框架中图像特征的学习,实现对脑膜瘤与听神经瘤的分类．图像增强参数与网络结构参数经过优化后,对脑膜瘤与听神经瘤分类的准确率达到0.918 0,曲线下面积（Area Under Curve,AUC）为0.913 4,实现了对桥小脑角区脑膜瘤与听神经瘤的有效判别．     

均相网状聚合物共混对链段运动的影响

本文制备了[m_1P_1P_2]C_1及[m_1P_1C_2P_2][C_1C_2G_12],并研究网状聚合物共混时两聚合物的混溶性、通过X射线透视及热力学特性的估算进行了检验、用经典的方法—蠕变实验来分析共混对链段运动的影响,并从蠕变特性求出滞后谱、另外应用热电松弛法分析共混对链段运动的影响、通过两种实验互相印证和补充,找出共混链段运动的规律,用以描述网状共混物的结构特性。     

Planar nonautonomous polynomial equations: The Riccati equation

We give a few sufficient conditions for the existence of two periodic solutions of the Riccati ordinary differential equation in the plane. We give also examples of the equation without periodic solutions.     

Transfer effects on communication and collision avoidance behavior from playing a three-dimensional auditory game based on a virtual auditory display

Transfer effects on two everyday auditory skills from playing an auditory game using a virtual auditory display (VAD) were investigated using two groups of 20 normally sighted participants. Representative auditory skills of blindfolded participants were pre-tested using communication and collision avoidance tasks. They performed the tasks two weeks later. Participants in a training group played the VAD-based game on seven days (30 min/day) during the two weeks: control group participants did not. Playing the VAD-based game significantly increased face-contacts in the communication task and significantly improved participants’ collision avoidance. No significant differences were found between the groups’ subjective ratings of the rated tension levels during the communication task or between rated levels for the collision threat. Performance revealed transfer effects of playing the VAD-based game on communication behaviors in social interaction and on avoidance of approaching objects: VAD-based games are effective training tools for auditory skills used in daily life.