Muscle oxygenation measurement in humans by noninvasive optical spectroscopy and Locally Weighted Regression

We have developed a method to make real-time, continuous, noninvasive measurements of muscle oxygenation (Mox) from the surface of the skin. A key development was measurement in both the visible and near infrared (NIR) regions. Measurement of both oxygenated and deoxygenated myoglobin and hemoglobin resulted in a more accurate measurement of Mox than could be achieved with measurement of only the deoxygenated components, as in traditional near-infrared spectroscopy (NIRS). Using the second derivative with respect to wavelength reduced the effects of scattering on the spectra and also made oxygenated and deoxygenated forms more distinguishable from each other. Selecting spectral bands where oxygenated and deoxygenated forms absorb filtered out noise and spectral features unrelated to Mox. NIR and visible bands were scaled relative to each other in order to correct for errors introduced by normalization. Multivariate Curve Resolution (MCR) was used to estimate Mox from spectra within each data set collected from healthy subjects. A Locally Weighted Regression (LWR) model was built from calibration set spectra and associated Mox values from 20 subjects using 2562 spectra. LWR and Partial Least Squares (PLS) allow accurate measurement of Mox despite variations in skin pigment or fat layer thickness in different subjects. The method estimated Mox in five healthy subjects with an RMSE of 5.4%.     

Adaptive lambda square dynamics simulation: An efficient conformational sampling method for biomolecules

A novel, efficient sampling method for biomolecules is proposed. The partial multicanonical molecular dynamics (McMD) was recently developed as a method that improved generalized ensemble (GE) methods to focus sampling only on a part of a system (GEPS); however, it was not tested well. We found that partial McMD did not work well for polylysine decapeptide and gave significantly worse sampling efficiency than a conventional GE. Herein, we elucidate the fundamental reason for this and propose a novel GEPS, adaptive lambda square dynamics (ALSD), which can resolve the problem faced when using partial McMD. We demonstrate that ALSD greatly increases the sampling efficiency over a conventional GE. We believe that ALSD is an effective method and is applicable to the conformational sampling of larger and more complicated biomolecule systems. © 2013 Wiley Periodicals, Inc.     

大学生化学竞赛对实验教学改革与创新人才培养的促进作用*

大学生的化学竞赛是课内实验教学的有效延伸,也是从学生视角对实验教学效果的有效检验。通过分析和比较学生参加化学实验竞赛的过程和效果,能有效促进化学实验教学改革、课程建设及创新人才的培养。近年来吉林大学化学学院学生实验竞赛的成绩显著提高,一方面通过化学竞赛激发本科生喜爱化学和开展化学研究的热情,增加学习的主观能动性;另一方面通过竞赛发现问题,在解决问题的过程中促进实验教学改革和课程建设,学院“三阶段”模式的竞赛活动开展,更加有利于培养学生的创新意识和创新能力,促进了化学创新人才的培养。     

农林院校校外实验教学基地分类考评机制及考评指标改革研究——大学化学校外实践基地实证分析*

针对大学化学校外实践教学基地建设和运行过程中的基地与高校的协同管理机制,实践教学基地软硬条件建设和资源配置及实践教学与理论学习的连贯性等问题,在OBE理论指导下,探究分类考核机制,在实证中构建分层次考评模型及考评指标,并建立适合于农林高校的化学校外实践教学基地的分类考评指标体系。     

工学结合人才培养模式的探索

工学结合体现了"以就业为导向,以能力培养为核心"的职业教育理念。无锡职业技术学院作为全国首批28所国家示范性院校之一,正在积极探索这种新的人才培养模式,市场营销专业作为该院制造业服务领域的重点专业,开展了"三明治"式"工学结合"人才培养模式的试点,取得了一定的成果,也遇到了一些问题。     

山东省信息资源管理人才建设战略思考

在评价山东省信息化建设现状的基础上,探讨了山东省信息资源管理的相关问题,并对山东省信息资源管理人才建设做了进一步分析。     

浅谈图书馆员应具备的知识素养

分析了当前我国图书馆员知识素养的现状,阐述了图书馆应具备的整体人才结构和图书馆员应具备的知识素养。     

论高校图书馆学习型馆员的培养

面对知识经济时代和高等教育发展的要求,高校图书馆必须重视学习型馆员的培养。分析了学习型馆员的特征和高校图书馆员的现状,阐述了学习型馆员的培养途径。     

吉林大学化学学科国际化人才培养模式的探索与实践

吉林大学化学学科作为国家“双一流”建设学科,始终将一流人才的培养作为不懈追求发展的根本目标。充分利用海外优质教育资源,建设与实施多元化、特色化的海外优质课程和国际交流项目,通过搭建外延式实践平台,支持能力阶梯式增长,为培养具有创新意识、实践能力、国际竞争力和家国情怀的高素质人才构建了多层次、国际化的创新人才培养模式,培养了大批化学领域的杰出人才。     

基于3×3平行排列耦合器的全光光开关的特性分析

提出了一种新型的基于3×3平行排列耦合器的全光光开关。此种光开关具有两个独立的输出端口且具有极好的偏振稳定性,消光比可达20dB。介绍了其工作原理,详细分析了信号光强度、控制光强度、光纤长度及耦合器分光比偏差等因素对各端口消光比的影响。比较了不同种类和长度光纤环的开关性能,首次得到了耦合器分光比偏差对消光比的影响曲线。