男女武术套路专业运动员运动损伤调查研究与比较分析

运用文献资料调查法、专家访谈法、问卷调查法、数据统计法、逻辑分析法对武术套路专业运动员练习拳术与器械时损伤的种类、组织部位,采取分性别进行比较分析,找出不同性别武术套路专业运动员练习拳术与器械时损伤的差异,为教练员在训练课中防止运动损伤提供参考依据.     

大鼠单侧睾丸扭转对未扭转侧睾丸的影响及红花的保护作用

为探讨大鼠单侧睾丸扭转对未扭转侧睾丸生精功能的影响及红花对未扭转侧睾丸早期损伤的保护作用,将21只健康雄性青春期前SD大鼠随机均分为假手术对照组(A组,n=7)、睾丸扭转复位组(B组,n=7)和睾丸扭转复位+红花组(C组,n=7).按Turner法建立睾丸扭转模型,喂养至术后7 d时处死,即刻采集各组大鼠未扭转侧睾丸标...     

Interaction between cardiovascular system and respiration

A set of nonlinear dynamic models for the interactive respiration/cardiovascular mechanism is constructed and analyzed in this work. By employing equivalent electric circuits for heart/blood and lung/air systems, the dynamics of cardiovascular system and respiration cycle are established. In order to verify the validity of the dynamic models, numerical simulations and analysis on heart–lung interactions, including the valvular closure incompetence and pulmonary obstruction, are presented and compared with the empirical reports in literature. The derived dynamics of heart–lung interactions can be realized and examined in the biomechanical and medical engineering fields. In addition, the dynamic models can also be employed for the model-based controller synthesis in medical instrumentations, e.g., the Extracorporeal Membrane Oxygenation (ECMO), to retain the function of blood circulation and/or respiration by artificial intelligence.     

多通道电化学基因传感阵列用于同时检测AML相关多药耐药基因的新方法研究

本研究筛选并制备高特异性 DNA 探针,与纳米粒子标记技术相结合,设计多通道电化学基因传感阵列检测模式,建立灵敏、快速、简便、经济的AML相关多药耐药基因(MDR1和MRP)检测新方法。该方法具有较好的特异性、灵敏度和重现性,能够在1.0×10-14 ~ 1.0×10-12 M和5.0×10-14 ~ 5.0×10-12 M范围内,分别实现对AML 相关多药耐药基因序列MDR1和MRP的定量检测。该方法有望为预测肿瘤治疗效果和临床制定治疗方案提供参考依据。     

Metabolomics analysis reveals Oct4 overexpression drives metabolic reprogramming and enhanced glycolysis and pentose phosphate pathway in lung adenocarcinoma cells

Poor prognosis in the underlying mechanisms involved in lung adenocarcinoma and its treatment leads to low survival rates in patients. Emerging evidence indicates that cancer is primarily a metabolic disease and metabolic reprogramming is a well-established hallmark and driving force of cancer. Oct4, acting as an oncogene, is a major regulator of cell pluripotency. It can reprogram the differentiated cells into cancer stem cells (CSCs) and plays an oncogenic role when pathologically hijacked. However, data that Oct4, the genetic reprogramming factor, could induce metabolic reprogramming have been very limited, and the direct evidence in metabolic level whether Oct4 reprograms metabolome is lacking. In the present study, integrated untargeted and targeted metabolomics analyses were utilized to investigate metabolic changes induced by Oct4 overexpression in lung adenocarcinoma cells. The results suggested that elevated expression levels of Oct4 drive metabolic reprogramming. Oct4 overexpression redirects glucose catabolism to glycolysis pathway and to the oxidative pentose phosphate pathway (PPP). This study identifies unique pathways that are candidate therapeutic targets for the treatment of lung adenocarcinoma. This study also aims to improve our understanding of the cancer-promoting activity of Oct4 and help identify novel diagnostic and therapeutic strategies for cancer treatment.     

论高校体育伤害事故的归责原则及责任分担形态

高校体育伤害事故在责任性质上应属于民事侵权责任，在责任归责原则上应适用过错责任原则，在责任分担上应实行自己责任、替代责任、相应的补充责任、公平责任等四种具体形态。     

男女武术套路专业运动员运动损伤调查研究与比较分析

运用文献资料调查法、专家访谈法、问卷调查法、数据统计法、逻辑分析法对武术套路专业运动员练习拳术与器械时损伤的种类、组织部位,采取分性别进行比较分析,找出不同性别武术套路专业运动员练习拳术与器械时损伤的差异,为教练员在训练课中防止运动损伤提供参考依据.     

Analytical methods for assessing metal bioaccessibility in airborne particulate matter: A scoping review

In contrast to the existence of standardized methods to assess metal bioaccessibility via the gastrointestinal route, there are no widely-accepted, established in vitro testing protocols to measure elemental solubility in the human lung. This may be attributed, in part, to the difficulty associated with simulating the lung’s complex in vivo conditions. The purpose of this review is two-fold: (1) to determine how the bioaccessibility of metals associated with ambient particulate matter (PM) in the human lung has been assessed in the literature, and (2) examine the suitability and biological relevance of applied methods for the measurement of metal bioaccessibility employed to date.     

2009年太原市饮用水水质分析及生物学安全评价

通过问卷调查,分别检测了2009年太原市集中供水和自备井水质,并对小店区农牧场自备井水进行了动物急性染毒与微核试验,结果表明太原市生活饮用水水质基本安全,太原西南区域部分自备井水质相对较差。     

不同用量酒精对大鼠肝急性损伤的病检

将48只大鼠随机分成对照组和5个实验组,每组8只.实验组1～5组每只大鼠分别按体重4、8、13、16、20g/kg一次性灌胃47.5%酒精,对照组每只大鼠按体重20g/kg一次性灌胃生理盐水,灌胃后24h取肝组织进行病检.结果显示实验组各组炎细胞浸润、水变性均为100%,实验组3～5组脂肪变性、点状/片状坏死均为100%,而对照组未见异常病变,表明47.5%酒精摄入量在13g/kg以上可造成较严重的急性肝损伤.