监护职责和监护责任--以《学生伤害事故处理办法》第7条为例

监护职责与监护责任在实际生活中往往被混为一谈。在处理学生伤害事故时，学校和监护人的责任，到底是一种什么责任，也往往引起人们的误解。监护职责与监护责任属于不同的范畴，两者在内容和能否约定转移上都有着明显的不同。     

健美操运动中的损伤与预防探讨

健美操是一种新型的体育运动项目。它集健身、健美、健心、娱乐、防病于一体,具有广泛的群众基础。在锻炼过程中,锻炼者往往因种种原因受到不同程度的损伤,给学习和工作带来诸多不便。本文分析了健美操运动中的损伤特点及原因,并提出了预防措施,为预防和减少该运动中的损伤提供了有益的指导。     

对完善我国工伤保险制度的思考

完善我国工伤保险制度的根本措施就是扩大工伤保险的范围、拓宽工伤保险基金的来源渠道，把工伤补偿与工伤预防、医疗康复、职业康复紧密地结合起来，不断提高工伤保险的管理水平。     

A molecular docking model of SARS-CoV S1 protein in complex with its receptor, human ACE2

The exact residues within severe acute respiratory syndrome coronavirus (SARS-CoV) S1 protein and its receptor, human ACE2, involved in their interaction still remain largely undetermined. Identification of exact amino acid residues that are crucial for the interaction of S1 with ACE2 could provide working hypotheses for experimental studies and might be helpful for the development of antiviral inhibitor. In this paper, a molecular docking model of SARS-CoV S1 protein in complex with human ACE2 was constructed. The interacting residue pairs within this complex model and their contact types were also identified. Our model, supported by significant biochemical evidence, suggested receptor-binding residues were concentrated in two segments of S1 protein. In contrast, the interfacial residues in ACE2, though close to each other in tertiary structure, were found to be widely scattered in the primary sequence. In particular, the S1 residue ARG453 and ACE2 residue LYS341 might be the key residues in the complex formation.     

Genomic variation and point mutations analysis of Indian COVID-19 patient samples submitted in GISAID database

Corona virus disease 2019 (COVID-19) endemic has havoc on the world; the causative virus of the pandemic is SARS CoV-2. Pharmaceutical companies and academic institutes are in continuous efforts to identify anti-viral therapy or vaccines, but the most significant challenge faced is the highly evolving genome of SARS CoV-2, which is imparting evolutionary selective benefits to the virus. To understand the viral mutations, we have retrieved nine hundred and thirty-four samples from different states of India via the GISAID database and analyzed the frequency of all types of point mutation in all structural, non-structural proteins, and accessory factors of SARS CoV-2. Spike glycol protein, nsp3, nsp6, nsp12, N and NS3 were the most evolving proteins. High frequency point mutations were Q496P (nsp2), A380V (nsp4), A994D (nsp3), L37F (nsp6), P323L & A97V (nsp12), Q57H (ns3), D614G (S), P13L (N), R203K (N), G204R (N) and S194L (N).     

预应力混凝土箱梁爆炸损伤评估及公式拟合

对预应力混凝土箱梁进行爆炸损伤评估研究。首先,对矩形梁进行爆炸数值分析,结合现场试验结果验证了爆炸数值模型的准确性、可靠性。其次,基于箱梁剩余承载力,建立了箱梁爆后损伤评估准则。通过对预应力混凝土箱梁在不同爆炸工况下的爆后剩余承载力计算,建立箱梁各损伤程度下P?I（超压?冲量）曲线。研究发现,混凝土强度对箱梁超压和冲量临界值影响较大,钢筋屈服强度对超压和冲量临界值影响较小。随着结构损伤等级的增大,各参数对箱梁P?I曲线的影响幅度各不相同。最后,对不同混凝土强度箱梁中各损伤等级P?I曲线进行公式拟合,并对拟合参数β进行分析。     

人非小细胞肺癌rasP^21和CD44的表达及意义

用免疫组化ＬＳＡＢ法检测４６例非小细胞肺癌ｒａｓＰ２１和ＣＤ４４的表达。结果：ｒａｓＰ２１的阳性率鳞癌为５９％,腺癌６３％;ＣＤ４４的阳性率鳞癌为４１％,腺癌６３％。统计学分析证明：不同临床分期的ｒａｓＰ２１表达强度有显著性差异（Ｐ＜００１）;有淋巴结转移与无淋巴结转移的ＣＤ４４表达程度有显著性差异（鳞癌Ｐ＜００１,腺癌Ｐ＜００２５）;ｒａｓＰ２１与ＣＤ４４表达强度两者无相关性（Ｐ＜００５）。结论：ｒａｓＰ２１的表达与预后不良有关,ＣＤ４４的表达与淋巴结转移有关。     

急性心肌梗塞泵衰竭患者QT离散变化及其临床意义

探讨老年急性心肌梗塞（ＡＭＩ）患者ＱＴ离散度（ＱＴｄ）、ＱＴｃ离散度（ＱＴｃｄ）与泵衰竭的关系。方法６１例老年ＡＭＩ患者分为两组：泵衰竭组（Ｋｉｌｉｐ分级泵功能≥Ⅲ级者,ｎ＝２１）和对照组（Ｋｉｌｉｐ分级泵功能Ⅰ级者,ｎ＝４０）。分析患者入院时心电图的ＱＴｄ和ＱＴｃｄ。结果：ＱＴｄ、ＱＴｃｄ在泵衰竭组分别为（６４６±１６０１）ｍｓ和（７７３３±２０６０）ｍｓ,在对照组分别为（５２７５±１４５０）ｍｓ和（６０９８±１５９３）ｍｓ,二组间比较差异有显著性（Ｐ＜００５）。结论：ＱＴｄ和ＱＴｃｄ增大与ＡＭＩ患者的泵衰竭有关,ＱＴｄ和ＱＴｃｄ可作为评估老年人ＡＭＩ早期泵功能和预后的指标     

急性纯氧对SD大鼠损伤的研究

SD大鼠暴露于1ATA100％的急性纯氧中,对其血细胞和肺脏进行研究,以阐明急性纯氧对机体的损伤机制．结果表明：SD大鼠暴露于100％急性纯氧中不同时间,血液中红细胞的浓度（RBC）,红细胞压积（HCT）,血红蛋白浓度（HGB）,平均红细胞血红蛋白含量（MCH）,平均红细胞体积（MCV）,平均红细胞血红蛋白浓度（MCHC）,白细胞浓度（WBC）等无显著变化（P＞0．05）;但是,白细胞的分类变化显著（P＜0．05）或非常显著（P＜0.01或P＜0．001）,淋巴细胞随SD大鼠在急性纯氧中暴露的时间延长不断下降,中性粒细胞和单核细胞的总数不断升高．急性氧中暴露65小时后,20％的大鼠死亡,存活的大鼠解剖,发现肺部出现严重的炎症,肺的湿重．脂质过氧化（LPO）产物显著增加（P＜0．001）,超氧化物歧化酶（SOD）活力明显下降（P＜0．001）．     

体育伤害事故中校方责任的认定及赔偿的研究

对学校体育伤害事故的校方责任的归责依据、校方承担赔偿责任的条件和赔偿方面的研究,对妥善处理伤害事故,维护学生、家长、教师和学校的合法权益,预防和减少事故发生,有着极其重要的意义.