计算经典Ramsey数R (3,q)下界的新方法

发现计算经典Ramsey数R(3,q)下界的一种新方法——自同构循环图的方法,并得到6个经典Ramsey数的新下界:R(3,35)≥226,R(3,37)≥241,R(3,38)≥246,R(3,40)≥261,R(3,43)≥281,R(3,44)≥293.     

Antiviral Activity of a Cyclic Pro-Pro-β3-HoPhe-Phe Tetrapeptide against HSV-1 and HAdV-5

The core of Cyclolinopeptide A (CLA, cyclo(LIILVPPFF)), responsible for its high immunosuppressive activity, contains a Pro-Pro-Phe-Phe sequence. A newly synthesized cyclic tetrapeptide, cyclo(Pro-Pro-β³-HoPhe-Phe) (denoted as 4B8M) bearing the active sequence of CLA, was recently shown to exhibit a wide array of anti-inflammatory properties in mouse models. In this investigation, we demonstrate that the peptide significantly inhibits the replication of human adenovirus C serotype 5 (HAdV-5) and Herpes simplex virus type-1 (HSV-1) in epithelial lung cell line A-549, applying Cidofovir and Acyclovir as reference drugs. Based on a previously established mechanism of its action, we propose that the peptide may inhibit virus replication by the induction of PGE2 acting via EP2/EP4 receptors in epithelial cells. In summary, we reveal a new, antiviral property of this anti-inflammatory peptide.     

Conjugates of Iron-Transporting N-Hydroxylactams with Ciprofloxacin

Screening of a library of novel N-hydroxylactams amenable by the Castagnoli-Cushman reaction identified four lead compounds that facilitated ⁵⁵Fe transport into P. aeruginosa cells (one of these synthetic siderophores was found to be as efficient at promoting iron uptake as the natural siderophores pyoverdine, pyochelin or enterobactin). Conjugates of the four lead siderophores with ciprofloxacin were tested for antibacterial activity against P. aeruginosa POA1 (wild type) and the ∆pvdF∆pchA mutant strain. The antibacterial activity was found to be pronounced against the ∆pvdF∆pchA mutant strain grown in CAA medium but not for the POA1 strain. This may be indicative of these compounds being ‘Trojan horse’ antibiotics. Further scrutiny of the mechanism of the antibacterial action of the newly developed conjugates is warranted.     

聚苯胺修饰电极的制备与形貌、阻抗表征

运用循环伏安(CV)法制取聚苯胺,结合扫描电子显微镜(SEM)、阻抗谱(EIS)等手段,对聚苯胺的表面形貌及其特征进行研究,并建立了聚苯胺覆盖Pt电极的阻抗模型.实验表明,随着循环次数的增加,聚苯胺膜厚增加,而且所制得的聚苯胺膜呈现多孔、疏松的特征,符合其作为基体材料的特点.     

纳米TiO2/聚苯胺复合膜电极的电化学制备及其表征

采用1 mol/L硫酸作为介质, 扫描速度为100 mV/s, 扫描电位为-0.2~0.8 V, 用循环伏安法在纳米二氧化钛（Nano-TiO₂）膜电极上实现了苯胺的电化学聚合 , 借助透射电镜、 原子力显微镜、 X射线衍射仪、 红外光谱对制得的Nano-TiO_{2/聚苯胺（Nano-TiO2/PANI）复合膜进行表征. 结果表明, 复合膜的生成、 峰电流的大小受溶液浓度、 扫描速度以及扫描电位的影响, 成膜速度随溶液浓度增大而加 快, 但膜稳定性降低, 峰电流随扫描速度和电位增大而提高, 可逆性降低, 复合膜中Ti O2以10~35 nm晶粒分散于聚苯胺中.}     

Access to nonisocyanate poly(thio)urethanes: A comparative study

This article describes the synthesis of new cyclic compounds able to react with amines to get nonisocyanate polyurethanes (NIPUs). The contribution of the most studied five‐membered cyclic carbonate was compared to five‐membered cyclic dithiocarbonate analogous and to a six‐membered cyclic carbonate. Difunctional reactive species were obtained by a simple substitution reaction or an efficient thiol–ene coupling reaction. The products, obtained with high yields, were characterized by 1H NMR, 13C NMR, and Fourier tansform infrared spectroscopy analysis. The dicyclocarbonates were then used to synthesize NIPUs by step growth polymerization with several diamines. These materials exhibited glass transition temperatures from 19 to ?29 °C, molar mass from 1800 to 20,400 g mol^?1, and a 20% mass loss temperature (T_d = 20%) between 249 and 296 °C. Such materials are interesting candidates for coating applications. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 3284–3296     

一种非平稳随机循环工况下的参数化载荷模型

为解决土方工程机械非平稳随机循环工况下,其零部件设计与试验中载荷表达的难题,提出一种参数化载荷模型.以液压挖掘机多路阀回转联为研究对象,将其阀口压力载荷数据通过小波变换分解为载荷随机项和载荷趋势项;其中具有平稳随机特征的载荷随机项利用功率谱估计等处理实现其随机项函数表达,具有非平稳特征的载荷趋势项利用随机变量表征工况的函数拟合实现其趋势项函数表达;再将两者组合重构为循环工况载荷函数.仿真与试验数据对比证明,该函数较好地复现了非平稳随机循环工况下多路阀载荷的随机特征.研究表明构建载荷模型的方法,对于实现面向循环工况特征的非平稳随机载荷的参数化表达,具有工程化应用的重要参考价值.     

循环应变下多晶铜非Massing现象的模拟

对多轴应力状态下的循环本构模型进行修正,在引入加载历史参数演化方程来刻画材料非比例特性的塑性模型基础上,通过在背应力演化方程中加入额外非线性项,以实现对金属材料非Massing现象的描述;利用隐式积分方法推导出新的应力和背应力积分方程以及整体迭代所需的一致切线刚度矩阵,借助有限元软件ABAQUS的用户子程序UMAT,将模型嵌入有限元分析软件中,对具有典型非Massing现象的多晶铜材料进行数值模拟,并将所得模拟结果与实验结果加以比较.结果表明,两者较吻合.     

细胞色素C在SAM修饰电极上的电化学行为

应用循环伏安法研究了细胞色素c在2-氨基乙硫醇自组装膜修饰金电极上的电化学行为。结果表明,细胞色素c在2-氨基乙硫醇修饰的金电极上的电子传递过程为—扩散控制的可逆反应,2-氨基乙硫醇自组装膜可用作细胞色素c电子传递的有效促进剂。依据电化学石英晶体微天平和电化学交流阻抗谱的测量结果,讨论了单分子膜的组装过程及其对促进细胞色素c电子传递的作用机制。     

框架-剪力墙混合结构层模型试验研究

为了解混合结构的滞回特性及变形性能,利用低周反复荷载试验对6个不同类型的框架-剪力墙结构进行了研究,得到了各个试件的滞回曲线.通过改变剪力墙刚度,框架柱类型以及轴压比,比较了各种因素对结构受力性能的影响.分析了各个试件的加载过程,破坏形态以及滞回曲线,并提出了数值分析方法对试件进行了模拟,最后得出结论,框架-剪力墙结构的抗侧刚度和变形能力主要取决于剪力墙,框架能够改善结构的变形能力,采用钢框架更有助于结构的抗震.