新一轮西部大开发背景下西部地区承接产业转移的问题与对策分析——以四川省为例

以四川省为例,对新一轮西部大开发背景下西部地区在承接产业转移过程中的利弊进行了分析。文章认为四川在承接产业转移中,区位、资源与政策环境方面具有比较优势,但也存在观念陈旧、产业结构比例不协调、产业配套能力弱、产业发展软环境不完善等问题。针对上述问题提出了相关对策建议。     

深水浊积水道型储层砂体连通性定量表征探索

在深水浊积水道型油田开发实践中发现,因砂地比较高、储层品质较好,作为开发单元的复合水道砂体表现为整体泛连通,但是在不同位置连通情况存在差异。为准确、精细地刻画水道砂体内部不同位置的连通程度,提升注采受效和开发效果,采用构型表征的方法,将储层砂体细分为构型单元和构型边界,结合西秦岭地区重力流沉积露头展现出的精细特征分别定量刻画其对连通性的影响,并通过地质模型应用于开发生产。研究发现,对高砂地比的浊积水道型储层而言,水道构型单元和水道构型界面同时影响连通性,且一般构型界面占主导,可以采用构型单元-界面二元表征的方法将砂体间特征对连通性的影响加以刻画;通过“连通系数”定量刻画和衡量砂体间的连通情况,并通过“等效替代”的方法计算连通系数。     

浅析东濮凹陷浅层砂岩储层的成岩特征

浅层油气藏具有低勘探成本投入、高开发收益回报优势,东濮浅层探明石油地质储量仅为3.9%,具有较大的勘探潜力。应用扫描电镜和铸体薄片技术,对东濮凹陷浅层储层进行了研究。首先通过对原始资料的综合整理分析,确定出本区的成岩演化阶段;然后通过具体观察成岩现象,总结出本区主要的成岩作用类型;在此基础上,阐述了研究区砂岩各阶段的成岩特点,探讨了成岩作用对砂岩储层孔隙结构的影响。     

海峡西岸经济区产业竞争力研究——基于层次分析法的实证研究

依据区域产业竞争力的内涵和层次分析法原理,构建了区域产业竞争力评价指标体系,对海峡西岸经济区工业产业竞争力进行了综合评价与分析,定性与定量相结合的实证研究表明:海峡西岸经济区竞争优势产业以劳动密集型为主,竞争优势呈现出较为明显的轻型化特征,产业结构优化步伐还要进一步加大;区域重点扶持产业优势并不明显,产业重点扶持力度要加大;高新技术产业和新兴产业竞争力偏弱,具有较大的增长空间。     

Prediction of 5-hydroxytryptamine transporter inhibitors based on machine learning

In patients with depression, the use of 5-HT reuptake inhibitors can improve the condition. Machine learning methods can be used in ligand-based activity prediction processes. In order to predict SERT inhibitors, the SERT inhibitor data from the ChEMBL database was screened and pre-processed. Then 4 machine learning methods (LR, SVM, RF, and KNN) and 4 molecular fingerprints (CDK, Graph, MACCS, and PubChem) were used to build 16 prediction models. The top 5 models of accuracy (Q) in the cross-validation of training set were used to build three different ensemble learning models. In the test1 set, the VOT_CLF3 model had the largest SP (0.871), Q (0.869), AUC (0.919), and MCC (0.728). In the unbalanced test2 set, VOT_CLF3 had the largest SE (0.857), SP (0.867), Q (0.865) and MCC (0.639). VOT_CLF3 was recommended for the virtual screening process of SERT inhibitors. In addition, 12 molecular structural alerts that frequently appear in SERT inhibitors were found (P < 0.05), which provided important reference value for the design work of SERT inhibitors.     

Antidepressant-like effect of triterpenoids extracts from Poria cocos on the CUMS rats by 16S rRNA gene sequencing and LC–MS metabolomics

Abstract

Poria cocos is an edible medicinal mushroom with the effects of inducing diuresis, excreting dampness, invigorating the spleen and tranquilizing the mind. The triterpenoids of Poria cocos as the main active ingredients have shown health benefits of the central nervous system of the human body. Accordingly, this study aimed at further understanding the antidepressant-like effect and a potential mechanism of the triterpenoids extracts from Poria cocos (TPC). As a result, the TPC significantly ameliorated depression-like behaviors on chronic unpredictable mild stress (CUMS) rats, and restored the levels of brain-derived neurotrophic factor and nerve growth factor in the hippocampus of rats. Gut microiota analysis revealed that TPC could increase the biodiversity and markedly regulate the relative abundance of [Prevotella], Allobaculum and Ochrobactrum of CUMS rats. The cecal contents metabolomics pointed to thirteen biomarkers associated with TPC antidepressant effect, which involved in primary bile acid biosynthesis, taurine and hypotaurine metabolism, arginine and proline metabolism. Correlation analysis further showed that there was a strong correlation relationship between the gut microbiota and the cecal contents metabolites, especially compounds involved in energy metabolism, inflammation and immunity. In conclusion, TPC showed a potential antidepressant effect, which was possibly mediated the gut microbiota and cecal contents metabolism.     

20世纪30年代美国大危机原因浅析

美国资本主义经历了独特的发展道路。一战后美国国家垄断资本主义由于共和党政府推行的自由放任政策未能得到充分发展，私人垄断资本主义的兴盛激化了资本主义基本矛盾，从而埋下了大危机的种手。30年代大危机是一场私人垄断资本主义的深刻危机。     

扬弃·改造·复兴──兼评《出路在于向西方乞灵》

中国传统音乐文化与西方音乐文化存在着相对性差距与绝对性差距。清醒地认识到这个事实，在坚持发挥本民族音乐的内在神韵与气质的同时，认真学习西方音乐文化中更丰富地展示人类灵魂的表现体制，才能为中国音乐的发展确定正确的方向，实现民族音乐的全面复兴。     

《华西教会新闻》中的西部印象及其形成原因

《华西教会新闻》是传教士在华西地区创办的一份重要刊物。它刊载了许多有关于中国西部的文章，构成了传教士对中国西部最直观的认识。本文通过对此刊物的研究，展现了传教士视野中的西部印象，并考察了传教士印象中所隐含的认识论问题。     

我国西部地区发展低碳物流的思考

发展低碳经济将成为我国一项重要的国策,物流业在发展低碳经济中起着重要的作用。我国西部地区物流业的发展相对滞后,物流业的能耗较高,碳排放量较大。文章首先阐述低碳物流的内涵,然后论述低碳物流是西部地区物流业调整与振兴的发展方向,提出西部地区发展低碳物流的对策。