银河系英仙臂的距离

以地球轨道半径为基线, 借助目前世界上最高分辨率的甚长基线干涉阵(VLBA), 通过测量英仙臂中大质量恒星形成区W3OH的三角视差, 得到了银河系中距离太阳最近的英仙臂的距离为1.95±0.04千秒差距 (5.86×1016km). 这个工作解决了天文学中关于英仙臂距离的长期争论, 说明英仙臂显示强的运动学反常.     

三江源地区全民健身体育开展活动现状分析

通过对三江源地区全民健身体育活动现状的调查和分析,提出了该地区民族体育发展的对策与建议．     

强相互作用理论的渐近自由——2004年诺贝尔物理学奖介绍

瑞典皇家科学院把2004年度的诺贝尔物理学奖授予了美国的戴维·格罗斯(David J. Gross),戴维·玻利泽(H. David Politzer),弗兰克·维里茨克(Frank Wilczek)三位理论物理学家,以表彰他们揭示出了强相互作用的'渐近自由'特性.文章按历史顺序,简要回顾了强相互作用理论——量子色动力学的基本“要素”.介绍了理论上如何得出强相互作用“渐近自由”和“渐近自由”的含义,引述了实验检验理论上的“渐近自由”最典型和最新的情况,展示了强相互作用“渐近自由”的高度正确性.介绍了基于“渐近自由”的微扰量子色动力学.指出“渐近自由”的发现和证实是确立量子色动力学为描述强相互作用的正确理论的依据,同时列举了当前量子色动力学的“色禁闭”等一些前沿问题.“渐近自由”的发现和证实确实深刻地影响了粒子物理,如量子色动力学成了标准模型的重要组成和导致相互作用的大统一理论等.     

TM01模虚阴极振荡器实验研究

在SPARK-04强流相对论电子束加速器上,对轴向反馈式虚阴极振荡器进行了实验研究,并采用远场测量方法对其激励的高功率微波辐射进行了测量,测得了微波辐射主模及辐射功率。结果表明：微波辐射主模为TM01模,辐射功率大于500 MW,微波转换效率大于3%,辐射频率约3.6 GHz,微波脉宽大于20 ns。同时,采用单反射面Vlasov天线,实现了该器件所激励高功率微波的定向传输。     

12 MeV直线感应加速器主开关的优化设计

介绍了12MeV直线感应加速器主开关的一种优化设计。在保持原有主开关的设计风格和接口结构的条件下,通过优化设计局部结构和调整开关电极尺寸,把主开关的结构电感从63.7nH减小到35nH,使得加速腔的高压脉冲前沿从39.6ns减小到27ns,从而有利于提高12MeV直线感应加速器的性能,验证了优化设计的可行性。     

低压铸造与紫铜结晶器研究

介绍了低压铸造的基本原理及优点,叙述了低压铸造技术在铜合金及紫铜材料领域的研究应用,研究了低压铸造紫铜的铸型材料选择及工艺设计方法,展望了低压铸造紫铜结晶器方面的发展前景,对实际生产具有一定的指导意义。     

西南少数民族地区中小城市社区体育环境研究——以湖南省吉首市为个案

西南少数民族地区的经济发展和社会的进步需要社区体育,而且也为社区体育的发展提供了经济基础;数千年积淀的民族体育精神为该地区当代社区体育的发展提供了肥沃的土壤.但制度环境的缺失是制约该区域社区体育发展的最大瓶颈,只有加强制度建设才能使该区域城市社区体育适应当地的城市协调发展.     

Virtual Screening of Artemisia annua Phytochemicals as Potential Inhibitors of SARS-CoV-2 Main Protease Enzyme

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a human coronaviruses that emerged in China at Wuhan city, Hubei province during December 2019. Subsequently, SARS-CoV-2 has spread worldwide and caused millions of deaths around the globe. Several compounds and vaccines have been proposed to tackle this crisis. Novel recommended in silico approaches have been commonly used to screen for specific SARS-CoV-2 inhibitors of different types. Herein, the phytochemicals of Pakistani medicinal plants (especially Artemisia annua) were virtually screened to identify potential inhibitors of the SARS-CoV-2 main protease enzyme. The X-ray crystal structure of the main protease of SARS-CoV-2 with an N3 inhibitor was obtained from the protein data bank while A. annua phytochemicals were retrieved from different drug databases. The docking technique was carried out to assess the binding efficacy of the retrieved phytochemicals; the docking results revealed that several phytochemicals have potential to inhibit the SARS-CoV-2 main protease enzyme. Among the total docked compounds, the top-10 docked complexes were considered for further study and evaluated for their physiochemical and pharmacokinetic properties. The top-3 docked complexes with the best binding energies were as follows: the top-1 docked complex with a −7 kcal/mol binding energy score, the top-2 docked complex with a −6.9 kcal/mol binding energy score, and the top-3 docked complex with a −6.8 kcal/mol binding energy score. These complexes were subjected to a molecular dynamic simulation analysis for further validation to check the dynamic behavior of the selected top-complexes. During the whole simulation time, no major changes were observed in the docked complexes, which indicated complex stability. Additionally, the free binding energies for the selected docked complexes were also estimated via the MM-GB/PBSA approach, and the results revealed that the total delta energies of MMGBSA were −24.23 kcal/mol, −26.38 kcal/mol, and −25 kcal/mol for top-1, top-2, and top-3, respectively. MMPBSA calculated the delta total energy as −17.23 kcal/mol (top-1 complex), −24.75 kcal/mol (top-2 complex), and −24.86 kcal/mol (top-3 complex). This study explored in silico screened phytochemicals against the main protease of the SARS-CoV-2 virus; however, the findings require an experimentally based study to further validate the obtained results.     

New Chemicals Suppressing SARS-CoV-2 Replication in Cell Culture

Candidates to being inhibitors of the main protease (Mpro) of SARS-CoV-2 were selected from the database of Voronezh State University using molecular modeling. The database contained approximately 19,000 compounds represented by more than 41,000 ligand conformers. These ligands were docked into Mpro using the SOL docking program. For one thousand ligands with best values of the SOL score, the protein–ligand binding enthalpy was calculated by the PM7 quantum-chemical method with the COSMO solvent model. Using the SOL score and the calculated protein–ligand binding enthalpies, eighteen compounds were selected for the experiments. Several of these inhibitors suppressed the replication of the coronavirus in cell culture, and we used the best three among them in the search for chemical analogs. Selection among analogs using the same procedure followed by experiments led to identification of seven inhibitors of the SARS-CoV-2 replication in cell culture with EC50 values at the micromolar level. The identified inhibitors belong to three chemical classes. The three inhibitors, 4,4-dimethyldithioquinoline derivatives, inhibit SARS-CoV-2 replication in Vero E6 cell culture just as effectively as the best published non-covalent inhibitors, and show low cytotoxicity. These results open up a possibility to develop antiviral drugs against the SARS-CoV-2 coronavirus.     

现代信息技术条件下《孙子兵法》在图书馆工作中的运用

从知己知彼、上下同欲、令之以文、择人任势等4个角度讨论了现代信息技术条件下《孙子兵法》在图书馆工作中的运用。