关于推广的Hardy-Hilbert积分不等式的一个等价式

通过引入权函数,建立推广的Hardy Hilbert积分不等式的一个等价式,并证 明其常数因子为最佳值.     

超立方体的渐近性质

设 KRn是超立方体,主要研究关于超立方体内随机单形的两个仿射不变量m2(K)、S2(K)的渐近性质.作为方法的应用,得到了质心在原点体积为1的超平行体的迷向常数LK.     

Microscale Thermophoresis and Molecular Modelling to Explore the Chelating Drug Transportation in the Milk to Infant

The microscale thermophoresis (MST) technique was utilized to investigate lactoferrin–drug interaction with the iron chelator, deferiprone, using label-free system. MST depends on the intrinsic fluorescence of one interacting partner. The results indicated a significant interaction between lactoferrin and deferiprone. The estimated binding constant for the lactoferrin–deferiprone interaction was 8.9 × 10⁻⁶ ± 1.6, SD, which is to be reported for the first time. Such significant binding between lactoferrin and deferiprone may indicate the potentiation of the drug secretion into a lactating mother’s milk. The technique showed a fast and simple approach to study protein–drug interaction while avoiding complicated labeling procedures. Moreover, the binding behavior of deferiprone within the binding sites of lactoferrin was investigated through molecular docking which reflected that deferiprone mediates strong hydrogen bonding with ARG121 and ASP297 in pocket 1 and forms H-bond and ionic interaction with ASN640 and ASP395, respectively, in pocket 2 of lactoferrin. Meanwhile, iron ions provide ionic interaction with deferiprone in both of the pockets. The molecular dynamic simulation further confirmed that the binding of deferiprone with lactoferrin brings conformational changes in lactoferrin that is more energetically stable. It also confirmed that deferiprone causes positive correlation motion in the interacting residues of both pockets, with strong negative correlation motion in the loop regions, and thus changes the dynamics of lactoferrin. The MM-GBSA based binding free energy calculation revealed that deferiprone exhibits ∆G TOTAL of −63,163 kcal/mol in pocket 1 and −63,073 kcal/mol in pocket 2 with complex receptor–ligand difference in pocket 1 and pocket 2 of −117.38 kcal/mol and −111.54 kcal/mol, respectively, which in turn suggests that deferiprone binds more strongly in the pocket 1. The free energy landscape of the lactoferrin–deferiprone complex also showed that this complex remains in a high energy state that confirms the strong binding of deferiprone with the lactoferrin. The current research concluded that iron-chelating drugs (deferiprone) can be transported from the mother to the infant in the milk because of the strong attachment with the lactoferrin active pockets.     

精密电压调节器TL431三种应用电路设计

介绍了三种精密电压调节器TL431的应用电路:不平衡直流电桥输出信号的稳定和线性化电路,恒流源电路,4~20mA/0~5V电流/电压转换电路。分析了电路工作原理,给出了电路设计方法。所设计的电路简单、新颖、实用。可广泛用于模拟电子电路,特别是传感器的信号调理电路中。由于采用了精密电压调节器TL431做基准电压源,因此电路精度高,稳定性能好。     

关于金属介电常数的讨论

考虑金属中的电子位移极化,利用谐振束缚电子模型,导出了金属中相对介电常数的表达式,并讨论低频极限和高频极限两种重要的特殊情况,对关于金属介电常数的一些说法作出了解释,从而对金属介电常数有了更为全面的理解。     

Preparation of modified polymer blend and electrical performance

In this study, a modified binary polymer blend made up of polycarbonate and polystyrene blend has been prepared by loading of aluminum oxide (Al₂O₃) as a dopant. The role of alumina with polymer blend system was addressed in view of interfacing criteria. The filler concentration of modified blend was taken as 5, 10, and 15%. The morphological, thermal, and electrical properties were characterized by various techniques. Optical microscopy confirms the homogenous dispersion of Al₂O₃ in blend. The presence of alumina was detected by subatomic level using atomic force microscope (both two and three dimensional approach). The differential scanning calorimetric thermographs demonstrate decreasing softing point as function of alumina loading. The dielectric properties such as dielectric constant, loss, and electrical modulus were studied under DC bias. The effect of DC bias exhibits significant changes at low amount of Al₂O₃. The dielectric polarization supports Maxwell Wagner (MW) theory due to low frequency response. 15% Al₂O₃ gives the highest dielectric constant (ε′) value (3.5?×?10⁵) at 10 Hz. The polymer modified blend with Al₂O₃ may be used as a one of the best dielectric medium.     

基于MEMS技术的平面W型微弹簧刚度特性研究

为了方便平面W型微弹簧的设计和制造,对其刚度特性表征方面进行了研究.运用能量方法推导出平面W型微弹簧弹簧常数计算公式.通过镍质平面W型微弹簧的实际拉伸实验,对推导出的微弹簧弹簧常数计算公式进行了验证,公式计算结果与测试结果基本相符.同时在有限元模拟分析软件———ANSYS中进行了仿真计算,二者一致性很好.在公式和仿真计算的基础上,找出了各结构参数对其刚度的影响规律.研究结果为平面W型微弹簧的优化设计与加工提供了理论指导.     

高充电效率的恒流太阳能路灯控制器

针对传统太阳能路灯控制器主要存在充电效率低、恒流精度低的问题,提出基于多路脉冲宽度调制(PWM)恒流技术的新型太阳能路灯控制器的设计方案。该控制器采用复合式DC-DC变换器,通过控制多路PWM信号,实现高效地充放电功能。充电过程以改进的扰动观察法实现最大功率点跟踪(MPPT),提高充电效率;放电过程通过实时检测LED路灯的实际电流,动态调整相应PWM信号的占空比实现高精度恒流驱动LED路灯。实物测试结果表明该控制器能有效地改善充电效率和恒流源精度,充电速度提高了4%~7%,恒流源精度高达2.5%。     

一阶RC电路阶跃响应实验改革

从培养学生的自主学习能力出发,对一阶RC电路阶跃响应实验进行改革,引导学生逐步理解并掌握RC电路的阶跃响应过程,并能够在给定条件下,自己设计RC积分和微分电路。     

复介电一维双周期光子晶体的透射谱结构及其特性

利用传输矩阵法研究一维双周期光子晶体的带隙结构、增益和衰减特性。结果表明:双周期一维二元和三元复合光子晶体的光子带隙结构具有宽禁带的特点,并且两带隙的交叠处出现了多个共振透射峰;当组成该光子晶体的一种介质为复介电且其虚部为负时,各共振透射模式都出现了不同程度的增益;随着复介电常量虚部的增加,各透射增益先增加后减少,中间存在一极值点,但是各共振透射模式出现透射增益极值点的虚部不同,且最大增益的大小也不同;当组成该光子晶体的一种介质的复介电虚部为正时,各共振透射模式的透射峰出现衰减。