A New Flavan-3-ol Glucoside from DaphniphyUum oldhami

A new flavan-3-ol glucoside, (-)-afzelechin-7-O-β-D-glucopyranoside (1), has been isolated from the stem of Daphniphyllum oldhami. The structure of the new compound was elucidated on the basis of detailed spectroscopic analysis and comparison with related compounds.     

乙基紫苏霉素硫酸盐的选择性远程DEPT和二维NMR研究

本文通过选择性远程DEPT和二维NMR实验研究了由紫苏霉素合成的乙基紫苏霉素硫酸盐的¹H和¹³C NMR谱,推定其结构为(1),并且对其NMR谱峰归属作了确定。     

钕、铽(Ⅲ)硝酸盐、水杨醛乙二胺双席夫碱、二甲亚砜三元配合物的NMR研究

用NMR的方法研究了新型稀土配合物:钕、铽(Ⅲ)硝酸盐与N,N-二亚水杨基乙二胺双席夫碱、二甲亚砜三元配合物的结构,并利用二维质子NOE谱和异核多量子相关谱完全归属了它们的质子和¹³C信号.     

A Valuable Synthetic Route to the Enantiopure Functionalized N-Substituted Aziridines

Chiral butyrolacto[3,4-b]-2(S)-6(R)-1-N-akylaziridines 7 were synthesized in enantiopure form utilizing racemic 5-methoxy-3-bromo-2(5H)-furanone (5) and available amines (6) as key precursors. After highly effective reduction of 7, the functionaiized 2(S),3(R)-dihyroxymethyl-N-alkylaziridines (8) were obtained in good yields with ≥98% ee. This is a simple and pratical method for the preparation of enantiopure aziridines which are important intermediates in the synthesis of biologic active molecules.     

Synthesis and Characterization of Novel N-Ferrocenesulfonyl Benzimidazole

A new series of ferrocenesulfonyl benzimidazle has been synthesized and characterized by 1H NMR, FT-IR and elemental analysis. They are expected to have special bio-activity.     

(20S)-O-硒代乙酰喜树碱衍生物的合成及其抗肿瘤活性研究

通过缩合反应合成了8个(20S)-O-硒代乙酰喜树碱衍生物(8-15),并就它们对胃癌细胞SGC-7901进行了体外抗肿瘤活性筛选,有4个新化合物具有较高的抗肿瘤活性,其中两个比喜树碱(母体化合物)或10-羟基喜树碱的活性还高.     

一种新的敏化/猝灭室温磷光: CTAB胶束中α-溴代萘敏化联乙酰的室温磷光猝灭

本文首次报道了将敏化和猝灭同时偶合在同一体系中的敏化/猝灭室温磷光新方法。体系中, CTAB胶束一方面增强α-溴代萘的室温磷光发射、α-溴代萘和联乙酰的三重态-三重态能量转移效率, 另一方面起到猝灭α-溴代萘敏化联乙酰发射的室温磷光的作用。CTAB对联乙酰的猝灭反应由三重态-三重态能量转移速率限制,求得α-溴代萘敏化联乙酰的三重态-三重态能量转移速率常数为1.76×10^9(mol.dm^-^3)^-^1s^-^1, CTAB对联乙酰的猝灭常数为7.82×10^7(mol.dm^-^3)^-^1s^-^1。详细研究了实验条件, 实现了猝灭法测定联乙酰,检测限达2.8×10^-^8mol.dm^-^3。     

N-(邻-氯苯基)氨基乙酸铜(Ⅱ)和N-(邻-甲基苯基)氨基乙酸铜(Ⅱ)的合成、晶体结构和电子结构

合成了N-(邻氯苯基)氨基乙酸铜(Ⅱ)和N-(邻甲基苯基)氨基乙酸铜(Ⅱ)的单晶体,测定了它们的晶体结构,并对其电子结构进行EHMO计算。N-(邻氯苯基)氨基乙酸铜(Ⅱ)属单斜晶系,空间群P2,/a.a=8.786(4),b=7.777(2),c=11.956(2)A,β=96.01(3)°,V=812.4A,Z=2,Dc=1.77g·cm~-;N-(邻甲基苯基)氨基乙酸铜(Ⅱ)属单斜晶系,空间群P2,/a,a=8.925(6),b=7.973(8),c=11.856(9)Aβ=96.23(6),V=838.6A,Z=2,Dc=1.55g·cm~(-?)。两配合物互为异质同晶。配合物中,铜原子为分子的对称中心,并与两个配位体的两个羧基氧和两个氨基氮原子形成四方形配位结构,平均Cu-O键长为1.902A,Cu-N为2.050A。量子化学计算表明,在配位键的形成中,铜原子的d轨道的作用均不大,但配体中苯环上取代基的性质对Cu-N键强度有一定影响。