IA免疫吸附剂血液灌流治疗系统性红斑狼疮病例研究

本文介绍用IA免疫吸附剂血液灌流临床治疗系统性红斑狼疮患者的研究结果。     

K—VT吸附剂吸附SLE病人循环免疫复合物初探

从成牛血清制得电泳纯的胶固素，将Ｋ在筛选条件下结合到ＶＴ树脂上制成Ｋ－ＶＴ吸附剂，每克吸附剂含Ｋ９．０ｍｇ，柱反应时可吸附３．２ｍｇ系统性红斑狼疮病人血浆中的循环免疫复合物。吸附剂在４℃或室温下存放六个月后，性能基本保持不变。吸附剂不吸附血清白蛋白及抗体ＩｇＧ，对血液中细胞破坏少。除可用于分析检测ＣＩＣ外，具有潜在的临床治疗前景。     

快速康复外科在肝癌肝切除术中的应用及对细胞免疫功能的影响

目的探讨快速康复外科（FTS）在肝癌肝切除患者围术期的临床应用效果及对细胞免疫功能的影响。方法选取择期行肝癌肝切除术患者48例,按随机数字表法分为FTS组与常规组,各24例,比较两组患者术后肝功能、细胞免疫功能及临床疗效指标。结果两组患者临床基线资料比较差异均无统计学意义（均P＞0.05）。术后第３天,FTS组TBil为（113.96±61.39）μmol/L,ALT为（146.17±72.51）U/L,AST为（155.04±54.04）U/L;常规组TBil为（165.25±64.38）μmol/L,ALT为（213.46±107.48）U/L,AST为（225.92±81.51）U/L,两组比较差异均有统计学意义（均P＜0.05）;FTS组CD3+、CD4+、CD4+/CD8+指标均明显优于常规组（均P＜0.05）。FTS组患者术后首次肛门排气时间、首次进半流质时间、首次排便时间均较常规组提前（均P＜0.05）,术后住院时间亦缩短（P＜0.05）。结论FTS理念用于肝癌肝切除术患者围术期处理可降低患者术后应激反应、提高术后细胞免疫功能,改善患者术后肝功能恢复效果、缩短术后肛门排气时间和住院时间,安全性好,加快患者康复,值得临床应用。     

Ligand-Controlled Stereoselective Synthesis and Biological Activity of 2-Exomethylene Pseudo-glycoconjugates: Discovery of Mincle-Selective Ligands

Glycoconjugate analogues in which the sp³-hybridized C2 position of the carbohydrate structure (normally bearing a hydroxy group) is converted into a compact sp²-hybridized exomethylene group are expected to have unique biological activities. We established ligand-controlled Tsuji–Trost-type glycosylation methodology to directly prepare a variety of these 2-exomethylene pseudo-glycoconjugates, including glucosylceramide analogues, in an α- or β-selective manner. Glucocerebrosidase GBA1 cleaves these synthetic pseudo-β-glucosylceramides similarly to native glucosylceramides. The pseudo-glucosylceramides exhibit selective ligand activity towards macrophage-inducible C-type lectin (Mincle), but unlike native glucosylceramides, are inactive towards CD1d.     

Biological role of the PAK4 signaling pathway: A prospective therapeutic target for multivarious cancers

p21 activated kinase 4 (PAK4) along with PAK5 and PAK6 are members of the type II family of PAKs. From the type II family, PAK4 is being assessed as an expansively investigated area. PAK4 acts as a serine/threonine kinase in response to Rho GTPases, while interaction partners and substrates are rapidly extended, implying a diverse range of cellular functions regulated by PAK4, including cell cycle progression, proliferation, survival, cell adhesion, motility, neuronal development, and immune defense. Thus, altered expression and function of PAK4 imparts numerous pathological conditions. The overexpressed and, in some cases, amplified PAK4 gene is revealed to be associated with a diverse range of cancers. Ongoing findings explain how PAK4 is involved in cancer progression, promoting cancer cell growth, survival, and metastasis with the corresponding activation and signaling schemes. Meanwhile, upstream activating and downstream effector molecules are increasingly identified to elucidate the exact mode of action on the cancer progression role of PAK4. A plethora of approaches targeting PAK4 is continuing to assess the potentiality of inhibitors to eradicate the growth and metastasis of cancers overexpressing PAK4. Here, we summarize the findings on the role of PAK4 and its signaling pathways promoting cancers and examine PAK4 as a promising target for multitype cancers.     

Cl_q—VT免疫吸附剂制备及其吸附循环免疫复合物性能初探

本文在最佳条件下将猪Ｃｌｑ与活化的ＶＴ树脂反应制备了Ｃｌｑ－ＶＴ免疫吸附剂，每克干重ＶＴ可结合０．５ｍｇＣｌｑ，可吸附１．４ｍｇ热凝聚人ＩｇＧ（ＡＨＧ）。ＳＤＳ—ＰＡＧＥ结果表明Ｃｌｑ－ＶＴ免疫吸附剂只对ＡＨＧ特鼻吸附，而不吸附其它血清蛋白。应用Ｃｌｑ－ＶＴ免疫吸附剂吸附ＳＬＥ病人血浆中循环免疫复合物（ＣＩＣ），结果表明约有５２％的ＣＩＣ被清除。Ｃｌｑ－ＶＴ免疫吸附剂只能一次性地使用。     

螺旋藻对病毒、癌症及免疫系统影响的最新研究进展(英文)

螺旋藻是一种蓝藻，它含有众多丰富的营养物质，随着对螺旋藻研究的深入进行，螺旋藻已引起医学专家和研究人员的重视．本文介绍了近年来有关螺旋藻抗病毒、抗癌和促进人体免疫功能的最新研究报导．近年来的研究表明螺旋藻及其提取物可以抑制ＨＩＶ１型病毒和多种病毒的体外繁殖，增强免疫系统的细胞免疫和体液免疫能力，使癌细胞受到抑制和退化，螺旋藻已被视为是一种理想的营养源和潜在的药源．     

免疫-遗传算法用于混合物重叠核磁共振信号解析

通过对免疫系统中抗体对外来抗原的识别、消除等过程的模拟,建立了一种新型的免疫算法模型.将标样信号作为抗体,混合物重叠信号作为抗原输入免疫算法模型,通过迭代运算,从抗原中消除抗体所表示的信息,当抗原被抗体完全消除时,即实现了混合物重叠信号的解析.对多组分混合氨基酸NMR谱图的解析结果证明,该算法可方便地用于多组分重叠信号的解析,为利用数据库解析混合物或生物大分子等物质的复杂NMR谱图开辟了一条全新的途径.     

一类免疫反应动力学模型解的周期性及稳定性

研究了一类免疫反应动力学模型的周期解及其稳定性,得到了存在唯一渐近稳定的周期解的充分条件。     

一类具有时滞的病菌-免疫力模型的定性研究

考虑病菌的一种信息交流机制,建立一类病菌与免疫系统竞争的时滞传染病模型.分析正平衡点的存在性、渐近稳定性、Hopf分歧的存在性.特别的,研究了无病平衡点E0 在奇异条件(R0=1)下的稳定性.数值模拟验证了所得理论结果.