NMR Studies of Drugs. Applications of Achiral and Chiral Lanthanide Shift Reagents to a 5-Substituted-4-thiazolidinone

The 60 MHz ¹H NMR spectra of racemic 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]-4-thiazolidinone, 1, have been studied in CDCl₃ solution at 28° with the achiral lanthanide shift reagent (LSR), tris (6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5-octanedionato)europium (III), 2, and the chiral LSRs, tris[3-(heptafluoropropylhydroxymethylene)- (+)-camphoratojeuropium(III), 3, and tris[3-(trifluoromethylhydroxymethylene-(+) -camphorato]europium (III), 4, Significant enantiomeric shift differences were observed in the presence of added 3, for the aryl protons of 1 that should permit direct determination of enantiomeric excess. Relative magnitudes of lanthanide-induced shift for the different nuclei of 1 with the three LSRs are compared and discussed in terms of preferred LSR binding sites. A favored conformation of 1 with respect to rotation about the C(5)-CH₂ bond is suggested.     

HFC32/HFCl43a/HFCl34a在空调/直接式蓄冷空调循环中替代HCFC22的研究

提出探讨了一种有希望替代HCFC22的三元混合工质—HFC32／HFCl43a／HFCl34a。理论制冷循环和水合性能分析表明。在推荐组成下该物系的热力学性质与HCFC22基本相当,理论制冷循环GOP和容积制冷量均略优于HCFC22,在空调循环蒸发工况下能够形成气体水合物。     

HFC技术及传输模型

ＨＦＣ结合了光纤和有线电视同轴接入的优势,是宽带通信中的一种重要的接入技术。对其进行了初步介绍,并给出一配合Ｃａｂｌｅ Ｍｏｄｅｍ 的高速宽带接入网方案。最后,还讨论了在ＨＦＣ系统中如何利用软件对其传输模型进行模拟、仿真。     

Hepatic lipid composition analysis using 3.0-T MR spectroscopy in a steatotic rat model

Purpose

To investigate the feasibility of in vivo assessment of hepatic lipid composition using 3.0-T proton magnetic resonance spectroscopy (¹H-MRS) in a steatotic rat model and compare it to histopathological and biochemical assessment.

Materials and Methods

Hepatic steatosis was induced by feeding rats with a methionine/choline-deficient (MCD) diet for 1, 2, 3, 5 or 7 weeks (n=5 per group). At the end of the diet period, ¹H-MRS of the liver was performed, and rats were sacrificed for histopathological and biochemical assessment of the liver. Spectra were acquired in a single voxel (1.2 cc) using a point-resolved spectroscopic sequence with TE/TR=35/2000 ms and 64 signal acquisitions. From the MR spectra, peak area ratios were calculated to estimate hepatic lipid composition.

Results

During MCD diet periods, hepatic steatosis significantly increased on histopathology (P<.001). The ¹H-MRS measurements of total hepatic fat content [1.3/(1.3+4.65) ppm] correlated strongly with histological macrovesicular hepatic steatosis (r=0.93, P<.001) and with the biochemical total hepatic fatty acids (r=0.94, P<.001). Total unsaturated fatty acids [TUFA, 5.4/(1.3+4.65) ppm] estimated with ¹H-MRS strongly correlated with the biochemical unsaturated fatty acids (r=0.90, P<.001). Polyunsaturated fatty acids [PUFA, 2.8/(1.3+4.65) ppm] estimated with ¹H-MRS strongly correlated with biochemical PUFA (r=0.91, P<.001). The proportion of total unsaturated fatty acids relative to the amount of total fatty acids (rTUFA, 5.4/1.3ppm) measured with ¹H-MRS strongly correlated with the biochemical amount of unsaturated relative to total hepatic fatty acids (r=0.81, P<.001). The proportion of PUFA relative to the amount of total fatty acids (rPUFA, 2.8/1.3 ppm) measured with ¹H-MRS correlated with the biochemical amount of PUFA relative to total fatty acids (r=0.59, P=0.005,) and with the biochemical amount of omega-6 PUFA relative to total fatty acids (r=0.73, P<.001).PUFA at ¹H-MRS correlated with the histopathologically assessed degree of lobular inflammation in the liver (r=0.57, P=.001).

Conclusion

3.0T ¹H-MRS is able to measure poly- and unsaturated hepatic fatty acids and this strongly correlates with biochemical assessment. This study provides evidence that 3.0-T ¹H-MRS is a noninvasive technique to assess hepatic lipid composition.     

应用软交换技术构建校园融合网络教学系统

软交换技术是实现新一代语音通信、多媒体和数据交互的核心技术,其开放性、灵活性和扩充性等优点,使软交换技术在下一代网络(NGN)的业务层面发挥核心作用。软交换技术构建的校园融合网络教学系统可实现CAN与HFC网的教学数据和教学节目的互通、教学方式的互动,使校园网络教学系统在教育教学应用中的功能得到进一步的扩展。     

Speed of Sound and Ideal-Gas Heat Capacity at Constant Pressure for HFC-125

IntroductionAccording to the revisions of the MontrealProtocol,HCFCs are scheduled to be phased outbefore 2 0 3 0 . There is no single- componentrefrigerant to replace HCFC- 2 2 at this moment,although some binary and ternary mixtures havebeen proposed,e. g.,the HFC- 3 2 /1 2 5 binarysystem is considered to be a promising substituteto replace HCFC- 2 2 . HFC- 1 2 5 is included in mostof these mixture candidates,so its thermophysicalproperties should be accurately known.Sound speed meas…     

Reaction of HCFC‐133a (CF3CH2C1) or HFC‐134a (CF3CH2F) with alcohols or phenols in DMSO in the presence of KOH

In an open glassware, heating a gas HCFC‐133a (CF₃CH₂C1) or HFC‐134a (CF₃CH₂F), KOH and a phenol (or an alcohol) in DMSO at 80°C gave ethers ROCF₂CH₂X and (E/Z)‐ROCF = CHX (X = Cl, F) in moderate yields.     

HFC下行信道削波对QAM误码率的影响

分析了副载波路复用模拟光纤传输系统中,引入ＭＱＡＭ方式的数据业务后,原模型的消波对数字信号的影响,认真分析了ＱｕｎＳｈｉ的论文,采用一咱新的零阶Ｂｅｓｓｅｌ函数近似式和一种快速收敛级数算法对消波造成的ＭＱＡＭ误码率进行计算,得出了一些较精确的结论。     

交互电视网与信息高速公路

从交互电视网的原理、架构、功能及实现方法 ,阐述交互电视网与信息高速公路的关系 ,及如何利用我国现有庞大的 CATV系统改造成为适合中国国情的信息高速公路。     

以HFC134a为制冷剂的喷射制冷实验研究

设计并搭建了喷射制冷系统性能研究实验台,选取HFC134 a作为制冷剂进行了喷射制冷实验研究。研究表明,在测试工况范围内,喷射系统的COP随蒸发温度的升高而增加,随冷凝温度的升高呈现先是基本不变,后迅速降低的趋势,随发生温度的升高先升高后降低;另外,研究还发现系统的COP随着冷冻水流量的增加而增加。