基于Verilog HDL的DDS相位累加器的一种优化设计

通过对基于VerilogHDL的DDS相位累加器的传统设计方法的对比分析,提出了应用流水线技术加法器与寄存器结合在一起进行相位累加器设计的方案,该方案既具有提高速度又具有节约资源的优点,并且以一个八位相位累加器为例,给出了实验仿真结果。     

SoC技术及其形成基础

SoC是利用EDA和HDL以及IP核，设计出性能价格比很高的片上系统。SoC技术是一最新设计方法的形成是许多电子技术发展的杰出成果。这些技术包括IC工艺、IP优化及EDA设计等。本文对SoC技术及其相关的技术作讨论。     

Calculation of equation of state of QCD at zero temperature and finite chemical potential

In this paper we calculate the equation of state (EOS) of QCD at zero temperature and finite chemical potential by using several models of quark propagators including the Dyson-Schwinger equations (DSEs) model, the hard-dense-loop (HDL) approximation and the quasi-particle model. The results are analyzed and compared with the known results in the literature.     

Calculation of equation of state of QCD at zero temperature and finite chemical potential

In this paper we calculate the equation of state （EOS） of QCD at zero temperature and finite chemical potential by using several models of quark propagators including the Dyson-Schwinger equations （DSEs） model,the hard-dense-loop （HDL） approximation and the quasi-particle model.The results are analyzed and compared with the known results in the literature.     

Enrichment of HDL proteome and phospholipidome from human serum via IMAC/MOAC affinity

High-density lipoproteins (HDLs) have anti-inflammatory and antioxidant properties and are potentially cardio-protective. Defective HDL function is caused by alterations in both the proteome and lipidome of HDL particles. As potential biomarkers, the development of analytical methods is necessary for the enrichment of HDLs. Therefore, a method for selective enrichment of HDLs using immobilized metal ion affinity chromatography (IMAC) and metal oxide affinity chromatography (MOAC) is presented. SPE-based isolation of HDLs from whole serum is adopted as an alternative to traditional ultracentrifugation methods followed by SDS–PAGE. The enrichment mechanism relies on isoelectric points of lipoproteins and metal oxide. Negatively charged lipoprotein particles interact with positively charged metal oxides and IMAC affinity, which acts as a cation. Identified proteins from HDL through MALDI–MS analysis are apo AI, AII, AIV, CI, CIII, E, J, M, H, serum amyloid A and other nonapoproteins that are part of HDL particles and perform cellular functions. This serum-based proteomics approach gives insight into the functional role of HDL. HDL-associated phospholipids have also been analyzed by LDI–MS. Results suggest that the adopted analytical strategy is a feasible idea to extract lipoproteins from serum. A comparative study of healthy and diseased samples using this approach will provide valuable information in future.     

Oxidative status of human low density lipoprotein isolated by anion-exchange high-performance liquid chromatography--assessment by total hydroxyoctadecadienoic acid, 7-hydroxycholesterol, and 8-iso-prostaglandin F(2alpha)

This study aims to measure the oxidative status of LDL from human plasma (n=26) as assessed by biomarkers for lipid peroxidation, total hydroxyoctadecadienoic acid (tHODE), 7alpha- and 7beta-hydroxycholesterol (t7-OHCh), and 8-iso-prostaglandin F(2alpha) (t8-iso-PGF(2alpha)) after subfractionation of LDL with an anion-exchange HPLC (AE-HPLC). LDL was separated and quantified by AE-HPLC as LDL-1, LDL-2, and LDL-3 in the order of the anionic charge of the LDL particles. The concentrations of tHODE, t7-OHCh, and t8-iso-PGF(2alpha) in both plasma and LDL subfractions were assessed after reduction and saponification. In this method, the free and ester forms of hydroperoxides, ketones, and hydroxides of linoleic acid and cholesterol are measured as tHODE and t7-OHCh, respectively. It was found that tHODE significantly correlated with the proportion of LDL-2 and LDL-3 as well as with the concentration of malondialdehyde-modified LDL in plasma. Further, by the analyses of LDL subfractions, the concentrations of tHODE, t8-iso-PGF(2alpha), and t7-OHCh in LDL-3 were found to be significantly higher than those in LDL-1 and LDL-2. These results clearly indicate that the extent of oxidation increases in the order of LDL-1相似文献   

可编程器件设计中跨时钟域的同步设计问题

介绍可编程器件异步设计中的亚稳态现象及其可能造成的危害,阐述同步设计的重要性.通过具体的设计实例论证了跨时钟域同步处理的必要性,并给出一种实现跨时钟域同步处理的方法和具体电路实例.     

基于VHDL语言的设计8位CISC微处理器实例

以8位的CISC微控制器为例,说明采用硬件描述语言（HDL）进行数字系统设计的方法．首先采用典型的模块化设计的思想把整个系统分解成数据处理通道和控制通道．数据处理通道主要负责数据处理等,包含所有内部寄存器、算术逻辑单元（ALU）、程序及堆栈指针等．控制通道主要负责系统的控制,其主要的核心部件为一个状态机、状态机根据指令的内容执行不同的控制操作,数据通道在控制通道控制下完成指令的操作内容．采用数据处理和控制独立设计的优点是可以根据他们各自的特点进行相应的设计、文中设计的微处理器可单独使用也可做嵌入式系统．     

High‐Density Lipoprotein Nanoparticles Deliver RNAi to Endothelial Cells to Inhibit Angiogenesis

Systemic delivery of therapeutic nucleic acids to target cells and tissues outside of the liver remains a major challenge. A biomimetic high‐density lipoprotein nanoparticle (HDL NP) is synthesized for delivery of a cholesteryl‐modified therapeutic nucleic acid to vascular endothelial cells (ECs), a cell type naturally targeted by HDL. HDL NPs adsorb cholesteryl‐modified oligonucleotides and protect them from nuclease degradation. As proof of principle, we deliver RNAi targeting vascular endothelial growth factor receptor 2 (VEGFR2) to ECs to effectively silence target mRNA and protein expression in vitro. In addition, data show that treatment strongly attenuates in vivo neovascularization measured using a standard angiogenesis assay and in hypervascular tumor allografts where a striking reduction in tumor growth is observed. For effective delivery, HDL NPs require the expression of the cell surface protein scavenger receptor type‐B1 (SR‐B1). No toxicity of HDL NPs is measured in vitro or after in vivo administration. Thus, by using a biomimetic approach to nucleic acid delivery, data demonstrate that systemically administered RNAi–HDL NPs target SR‐B1 expressing ECs to deliver functional anti‐angiogenic RNAi as a potential treatment of cancer and other neovascular diseases.     

基于FPGA的温度控制系统设计与实现

基于FPGA与温度传感器DS18B20设计实现了单回路水箱温度PID控制系统.软件主要包括PID控制算法及PWM波产生模块、DS18B20驱动模块、数码管显示驱动模块等3个模块.仿真结果验证了设计的正确性.实验结果表明,系统输出温度达到微小超调的稳定控制要求.体现了该设计方法的有效性和实用性.