论杜甫人文精神的构成要素

杜甫人文精神的构成要素,以积极入世为主线,包括相互联系的三个方面,即:悲天悯人的仁者、无私勇猛的批判者和至真至纯的有情者。研究和学习杜甫的人文精神,对今天的精神文明建设有重要的借鉴作用。     

从杜定友探讨图书馆员素养

杜定友是我国著名的图书馆学家,从其本人及其著作中我们可以了解到为做好图书馆工作,图书馆员应具备的素养,包括责任心、图书馆学知识及某些科学知识等。     

逢迎父权文化面具下的女权主义——解读达夫妮·杜穆里埃的《蝴蝶梦》

达夫妮·社穆里埃的小说《蝴蝶梦》是英国20世纪的一部经典作品,自问世以来,一直得到文学界的关注。本文依据英国传记作家格丽特·福斯特的《达夫妮·杜穆里埃》英文传记,从当代女权批评理论角度对这部现代女性文学的经典之作进行解读：作者达夫妮·杜穆里埃在其作品中假意逢迎父权文化,实际上是在屈服的伪装下对父权文化进行颠覆,是借助女主人公来体现自己的女权主义主张,表达自己对女权主义的崇拜。     

分数阶导数的Du Bois-Reymond引理及其在分数变分问题中的应用

考虑Riemann-Liouville分数导数意义下的分数变分问题.首先,对于这类分数变分计算,证明了与古典Du Bois-Reymond引理相对应的结果.然后,应用该结果建立了分数变分泛函的Euler必要条件.最后,讨论了全局极值问题,得到了一些全局极值存在的充分必要条件.     

试论公孙大娘剑器舞的道具、套路及其在舞蹈史上的地位

利用历史文献资料,结合体育舞蹈教学的专业技术,对杜甫《观公孙大娘弟子舞剑器行》诗中所谓"公孙大娘剑器舞"的道具、套路及其在中国舞蹈史上的地位作初步探讨。认为公孙大娘剑器舞是一种女子戎装持剑表演的健舞,公孙大娘表演的剑器舞至少有四个套路,即剑器浑脱、西河剑器、邻里曲与裴将军满堂势,并从她成就了"草圣"张旭的书法艺术及其在中国舞蹈历史上的崇高地位来肯定公孙大娘剑器舞的深远影响。     

论黄庭坚学杜及其得失

黄庭坚对杜甫和杜诗非常推崇,既注重其思想意义,更推崇其艺术技巧。黄庭坚在自己的诗歌中大量使用杜诗的典故,作诗喜以杜诗为韵,更重视对杜诗句法的学习。但是,黄庭坚学杜颇有未至之憾,他的诗好用僻典,在句法和形式上故意求奇求怪,并有以文为诗的倾向。他的诗歌题材狭窄,眼界不宽,也缺乏情韵,特别是对民生疾苦不大关心。这都是黄庭坚诗歌的学杜未至之处,也是其诗歌的不足之处。     

好古而不遗今——从杜甫对六朝诗歌的评价看其“中和”思想

＂中庸＂作为儒家的核心思想,对＂奉儒守官＂、＂一生却只在儒家界内＂的杜甫有着深刻的影响。文章以杜甫对六朝诗歌的评价为中心,通过与陈子昂、李白以及元结文学主张的比较,侧重分析杜甫诗歌理论中所体现的＂中和＂思想。杜甫主张＂历代各清规＂,＂不薄今人爱古人＂,＂转益多师是汝师＂,以他所坚守的儒家标准,使其文学主张取得了＂好古而不遗今,务华而不去实＂的＂中和＂效果,这从一个侧面表现了杜甫的＂中和＂思想。     

农地石漠化预警指标分析——以广西都安瑶族自治县为例

以广西都安瑶族自治县为例,应用主成分分析法对农地石漠化预警指标体系进行分析,提出农地石漠化治理和农业优化调控应当从控制人类活动,改善社会环境着手。     

Research on the change of chemical composition in productive process of Re Du Ning injection by HPLC/Q‐TOF MS

A high‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry (HPLC/Q‐TOF MS) was developed for the analysis of chemical composition change in the production process of Re Du Ning injection, a Chinese medicine preparation with a combination of Lonicera japonica Thunb., Gardenia jasminoides Ellis and Artemisia annua L. A total of 90 compounds from raw materials–intermediates–Re Du Ning injection were detected; among them, 55 compounds were identified or tentatively characterized, and the characteristic ions of different types of compounds were described. Based on these studies, the different types of compounds in the various process routes were analyzed. A total of 28 compounds, including seven iridoid glycosides and six monoterpenes from G. jasminoides Ellis, five iridoid glycosides, nine phenolic acids and one unknown compound from L. japonica Thunb., were transferred to Re Du Ning injection, and two unknown compounds were generated in the production process of Re Du Ning injection. The results indicated that the Chinese Medicine Pharmaceutical process control is very important. This method could provide some reference for other Chinese medicine preparations. Copyright © 2015 John Wiley & Sons, Ltd.     

Direct inhibition of Re Du Ning Injection and its active compounds on human liver cytochrome P450 enzymes by a cocktail method

The aim of this study was to investigate the direct inhibitory effects of Re Du Ning Injection (RDN) and its active compounds on the major cytochrome P450 enzyme (CYP) isoforms (CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 and CYP3A4) of human liver microsomes by ‘a cocktail method’. The activity of each CYP isform was represented as the formation rate of the specific metabolite from relevant substrate. Then a sensitive and specific ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was developed and validated to simultaneously analyze the seven metabolites. RDN (0.035–2.26 mg/mL) showed a strong inhibitiory effect on CYP2C8, followed by CYP2C9, CYP2B6, CYP2C19, CYP1A2 and CYP3A4. The IC₅₀ value for each enzyme was 0.19, 0.66, 0.72, 1.27, 1.66 and 2.13 mg/mL, respectively. RDN competitively inhibited the activities of CYP1A2 (K _i = 1.22 mg/mL), CYP2B6 (K _i = 0.65 mg/mL) and CYP3A4 (K _i = 0.88 mg/mL); it also exhibited mixed inhibition of CYP2C8, CYP2C9 and CYP2C19 with a K _i value of 0.26, 0.64 and 0.82 mg/mL, respectively. However, the activity of CYP2D6 was not significantly inhibited even by 2.26 mg/mL RDN. Moreover, the data of nine active compounds on the CYPs showed that cryptochlorogenin acid, sochlorogenic acid B and sochlorogenic acid C were the major contributors to the inhibitory effect of RDN on CYP2C8, while the inhibitory effect of RDN on CYP2C9 might be caused by sochlorogenic acid A and sochlorogenic acid C. Moreover, neochlorogenic acid might be the major contributor to the inhibitory effect on CYP2B6. All of the findings suggested that drug–drug interactions may occur and great caution should be taken when RDN is combined with drugs metabolized by these CYPs.