三仁汤在多种湿热病中的运用

分析三仁汤组方原则的特点：ｌ）三焦并治，湿热兼清；２）组方轻灵，疏通气机；３）畅通三焦，先开肺气；４）法除湿邪，重在利小便。提出三仁汤可作为治疗多种湿热病的基础方及九种加减运用法。     

合理选择范德瓦耳斯修正常数

本文以氮气为例,讨论了合理地选择范德瓦耳斯修正常数a和b的问题,使范氏方程能在更大范围内更精确地描述实际气体的性质,获得了良好的结果。     

颠覆与反叛——《死亡与少女》的深层解读

2004年诺贝尔文学奖得主奥地利女作家埃尔夫丽德·耶利内克在其作品中总是以叛逆而激进的姿态书写着世界的荒诞、人性中极端丑恶的存在。其作品《死亡与少女》从表面上看完全是一种无序的戏剧呈现，是种种光怪陆离的破碎形象的堆积、没有表演的“语言平面”。然而正是在这种对传统戏剧模式的颠覆和反叛中作者展示出对哲学与文学的深层解读。     

动电学效应下微流动近壁面带电离子受力分析

应用离子分布的Boltzmann定律和Poisson方程研究了微流动中通道近壁面电势的分布,采用Derjaguin理论计算了动电学效应下带电离子受到的双电层作用力,应用Hamaker-De Boer 近似式得到了离子与壁面间的范德瓦尔力,同时也考虑到离子重力的影响,揭示了三种力对带电离子流动特性的影响.研究结果表明:无量纲间距d~*≤0.2时,离子重力的影响可以忽略,带电离子主要受范德瓦尔力和双电层作用力的作用,且二力均随d~*增大而减小,d~*≤0.02时,范德瓦尔力起主要作用,当0.020.2时,重力、范德瓦尔力及双电层作用力都趋于零,均可忽略.     

非自治范德波振子的随机振动

利用数值模拟方法对非自治范波振子（ＮＡＶＤＰＯ）进行模拟,获得了ＮＡＶＤＰＯ的概率密度流及其位移－速度联合速率密度流,发现ＮＡＶＤＰＯ存在复杂的时间分岔,也存在复杂的结构分岔,它的演变可以是单峰状态,也可以是多峰状态。ＮＡＶＤＰＯ的联合概率密度存在孤立的四峰,对应复杂的跳跃运动,文中分析了这些行征的性质和意义。     

A reactivity pattern for discrimination of ER agonism and antagonism based on 3-D molecular attributes

Various models have been developed to predict the relative binding affinity (RBA) of chemicals to estrogen receptors (ER). These models can be used to prioritize chemicals for further tiered biological testing to assess the potential for endocrine disruption. One shortcoming of models predicting RBA has been the inability to distinguish potential receptor antagonism from agonism, and hence in vivo response. It has been suggested that steroid receptor antagonists are less compact than agonists; thus, ER binding of antagonists may prohibit proper alignment of receptor protein helices preventing subsequent transactivation. The current study tests the theory of chemical bulk as a defining parameter of antagonism by employing a 3-D structural approach for development of reactivity patterns for ER antagonists and agonists. Using a dataset of 23 potent ER ligands (16 agonists, 7 antagonists), molecular parameters previously found to be associated with ER binding affinity, namely global ( E HOMO ) and local (donor delocalizabilities and charges) electron donating ability of electronegative sites and steric distances between those sites, were found insufficient to discriminate ER antagonists from agonists. However, parameters related to molecular bulk, including solvent accessible surface and negatively charged Van der Waal's surface, provided reactivity patterns that were 100% successful in discriminating antagonists from agonists in the limited data set tested. The model also shows potential to discriminate pure antagonists from partial agonist/antagonist structures. Using this exploratory model it is possible to predict additional chemicals for their ability to bind but inactivate the ER, providing a further tool for hypothesis testing to elucidate chemical structural characteristics associated with estrogenicity and anti-estrogenicity.     

粉尘螨Der f15的基因克隆与其表达载体的构建

先挑取纯培养的粉尘螨,提取总的RNA,后采用RT-PCR方法进行反转录出cDNA.由cDNA提取出目的基因进行片段扩增,产物连接入T载体(pMD18-T).经扩增后,用EcoR I和Xho I双酶切,将目的基因分别连接到pET28和pET32的表达载体上,得到重组质粒pET28和pET32,即粉尘螨的基因克隆与 表达载体构建成功.     

参激Duffing-Van Der Pol振子的混沌演化与激变

运用分岔图、相图、Poincare截面图、快速傅里叶变换(FFT)图、最大Lyapunov指数图、吸引域等各种数值方法,研究了Duffing-Van Der Pol振子在参数激励下的一系列动力学行为,揭示了该系统复杂的分岔、混沌现象.通过共存时吸引子及相应吸引域的变化,研究了混沌吸引子的形成与激变.