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91.
Summary A high-performance liquid chromatographic method for the separation and determination of gastrodin,p-hydroxybenzyl alcohol, vanillyl alcohol,p-hydroxylbenzaldehyde and vanillin in extract of Chinese herbal medicine tall gastrodia tuber (Chinese name: Tianma) was established.
The chromatographic conditions were optimized by means of computer-assisted method development technique. Dry-Lab software
was used to model the retention behavior of the compounds as a function of gradient conditions, based on the data from two
scouting gradient runs. Under the optimized conditions: column, Kromasil-C18, 5 μm, 15×0.46-cm; solvent A, water; solvent
B, methanol; gradient, 5/44/65/65% B at 0/9/12/15 min; flow rate, 1.00 mL min−1; temperature, ambient, the quality of tall gastrodia tubers from different sources and tianma injection were examined. 相似文献
92.
IDENTIFICATION OF PARTIAL MUTATIONAL SITES IN HUMAN MITOCHONDRIAL DNA IN THE CHINESE AND ITS SIGNIFICANCE 总被引:1,自引:0,他引:1
A simple method for the identification of mutational sites in human mitochondrial DNA (mtDNA) was described. It was based on the human Cambridge sequence as a relative standard sequence and a single base pair substitution in mtDNA as a unique mutational form. The partial mutational sites can be determined using this method which was characterized by combining the restriction mapping with the analysis for the table of human mtDNA potential mutational sites with rapidity and simplicity. In the meanwhile, six mtDNA mutational sites found in Chinese population were identified by means of this method. 相似文献
93.
Two natural products databases, the marine natural products database (MNPD) and the traditional Chinese medicines database (TCMD), were used to find novel structures of potent SARS-CoV protease inhibitors through virtual screening. Before the procedure, the databases were filtered by Lipinski's ROF and Xu's extension rules. The results were analyzed by statistic methods to eliminate the bias in target-based database screening toward higher molecular weight compounds for enhancing the hit rate. Eighteen lead compounds were recommended by the screening procedure. They were useful for experimental scientists in prioritizing drug candidates and studying the interaction mechanism. The binding mechanism was also analyzed between the best screening compound and the SARS protein. 相似文献
94.
碘酸钾存在下极谱催化波法测定陈皮甙 总被引:2,自引:0,他引:2
基于陈皮甙在KIO3存在下产生的极谱催化波,拟定了测定陈皮甙的新方法。在 0.55 mol/L HAc-0.01mol/L NaAc(pH 4.00±0.05)-1.0×10~(-3)mol/L KIO3缓冲溶液中,陈皮甙催化波的峰电位为-1.35 V(vs,SCE),它的一阶导数峰峰电流与陈皮甙浓度在2.6 × 10~(-7)~2.6 × 10~(-6)mol/L范围内呈线性关系(r=0.9970,n=6)。本方法比现有的电化学方法灵敏度高一个数量级。可用于直接测定中草药贯众水提液中陈皮甙含量。 相似文献
95.
《Arabian Journal of Chemistry》2022,15(7):103933
In this study, a fingerprint-activity relationship modeling between chemical fingerprints and antirheumatic activity was established, and multivariate statistical analysis was used to evaluate the quality of Taxilli Herba (TH) from different hosts. Characteristic fingerprints of 20 batches of TH samples were generated by high-performance liquid chromatography coupled with triple quadrupole-time of flight tandem mass spectrometry (HPLC-Triple TOF-MS/MS), and the similarity analysis was calculated based on thirteen common characteristic peaks by hierarchical clustering analysis (HCA). Subsequently, nine efficacy markers were discovered by combining fingerprints and antirheumatic activity through grey correlation analysis (GCA) and bivariate correlation analysis (BCA). Meanwhile, the content of 5 constituents in 9 markers was determined by high-performance liquid chromatography coupled with triple quadrupole-linear ion trap tandem mass spectrometry (HPLC-QTRAP-MS/MS). The comprehensive quality of TH was assessed using multivariate statistical analysis, including principal components analysis (PCA) and technique for order preference by similarity to ideal solution (TOPSIS). The results showed that a high dose of TH extract could markedly ameliorate arthritis damage compared to other doses, with flavonoids playing an important role in the antirheumatic activity. The comprehensive quality of samples from Morus alba L. (SS) was superior to those from Liquidambar formosana Hance (FXS). The present study will demonstrate the markers associated with efficacy, and provide an applicable strategy for more comprehensive quality control and evaluation of TH. 相似文献
96.
ComputerHandlingofChemicalandBiologicalDataofTraditionalChineseMedicinesCHEChun-taoa**,PaulR.CarlieraandOpheliaC.W.Leeb(aDepa... 相似文献
97.
中共第一代领导集体的特点 总被引:1,自引:0,他引:1
中共第一代领导集体的特点十分鲜明,主要体现为作风优良、民主团结、核心突出、独立自主、素质超凡、旗帜鲜明。中共第一代领导集体在党的历史上存在时间最长,影响最大,它的稳固发展是中国革命和建设事业不断取得胜利的决定性因素。 相似文献
98.
夏显泽 《曲靖师范学院学报》2005,24(2):1-5
韩愈的天人感应论属于我国古代天人感应论的第四种类型,他从“天入相乖”、“祸善福淫”的角度提出了天与入感应的独特方式。从当代环境伦理学视角看,韩愈的天人感应论表达了对大自然的道德关怀,与当代环境伦理学一样,具有强烈的反传统人类中心主义倾向以及相似的基本原则和道德目标。在环境问题日益严重的今天,探讨韩愈的天人感应论,对我们坚持科学发展观,处理好发展经济与保护环境的关系,搞好社会主义和谐社会建设,具有一定借鉴意义。 相似文献
99.
100.
根据大型土木结构环境振动的特点,利用频域法对桥梁的模态参数进行识别,详细阐述了峰值检测法和复模态指示函数法识别桥梁模态参数的理论依据和实现方法,对比了两种方法各自的特点.利用香港汀九大桥的实测数据,辨识出了桥梁的模态参数,最后的辨识结果表明该方法在具体的工程应用中的有效性. 相似文献