重症新型冠状病毒感染药物治疗的研究进展

新型冠状病毒引起的新型冠状病毒感染(Coronavirus Disease-2019,COVID-19)在全球流行爆发,严重威胁人类生命健康,给全球造成了巨大的医疗、经济和社会破坏。重症COVID-19患者病死率高,目前无特效治疗药物,现有的药物治疗主要是通过抑制病毒复制、抗炎及免疫调节等机制起效。对于COVID-19患者,早期使用合适、有效的治疗药物会降低住院率及死亡率,并降低医疗成本,减轻医务人员负担。本文对重症COVID-19患者治疗药物的研究进行综述,拟为临床救治COVID-19患者的药物选择提供参考。     

COVID-19疫苗相关性心肌炎研究进展

新型冠状病毒感染(Coronavirus Disease 2019,COVID-19)给人类健康、社会经济发展及全球医疗和公共卫生系统带来了严重的威胁,因此研发安全有效的特异性疫苗至关重要。目前,基于腺病毒载体和mRNA等技术开发的多款疫苗已在人群中广泛接种,然而疫苗接种可能导致的不良反应不容忽视。除了在临床试验中观察到的接种后疲劳、发烧和肌痛等常见不良反应外,疫苗相关性心肌炎正逐步引起人们的关注。在全球范围内已有多例COVID-19疫苗相关性心肌炎导致死亡的病例报道,对接种人群的健康危害较大。因此,本文对COVID-19疫苗相关性心肌炎的发生概况以及其潜在的发生机制进行综述,认为COVID-19疫苗相关性心肌炎的发生与疫苗的类型、接种剂次以及接种人群特征等因素都存在一定的相关性,而且不同类型疫苗引起心肌炎的机制各不相同。未来仍需结合临床数据开展更多的基础研究,以明确疫苗相关性心肌炎发生的具体机制,从而研发更加安全有效的新型COVID-19疫苗,降低疫苗相关性心肌炎的发生率。     

非线性组合动态传播率模型与我国COVID-19疫情分析和预测

针对传统的流行性传染病学中基本传染数R0难以准确估计以及单一模型预测精度低的缺陷,利用组合动态传播率替换基本传染数R0,提出基于支持向量回归的非线性时变传播率模型并对我国COVID-19疫情进行分析和预测.首先,计算动态传播率的离散值;其次,使用多项式函数、指数函数、双曲函数和幂函数分别对动态传播率的离散值进行拟合并基...     

Are Mobility and COVID-19 Related? A Dynamic Analysis for Portuguese Districts

In this research work, we propose to assess the dynamic correlation between different mobility indices, measured on a daily basis, and the new cases of COVID-19 in the different Portuguese districts. The analysis is based on global correlation measures, which capture linear and non-linear relationships in time series, in a robust and dynamic way, in a period without significant changes of non-pharmacological measures. The results show that mobility in retail and recreation, grocery and pharmacy, and public transport shows a higher correlation with new COVID-19 cases than mobility in parks, workplaces or residences. It should also be noted that this relationship is lower in districts with lower population density, which leads to the need for differentiated confinement policies in order to minimize the impacts of a terrible economic and social crisis.     

信息反馈在中学英语教学中的研究及其应用

信息反馈在英语教学中有着很大的作用,作为英语教师,应注意前后信息反馈的积累和总结,在教学中注意及时、多层次、多样化反馈,注意培养学生的自我反馈.同时,教师自身应努力学习教学法,不断提高反馈能力.     

The Identification of Two New Sterols from Marine Organism

Marineorganismsproducedmanyinterestingphannacologicallyandbiologicallyactiviemetabolitessuchasantibacterium,anticancerandantimicrobialactivecompounds'-'.lnrecentyears,avarietyofsterolshavebeenreportedfrommarineinvertebratesandsponges'-'.Moreandmorechemistsandbiologistspayattentiontotheconstituentsofspongesandcorals.ThirteencompoundshavebeenisolatedfromthespongePolymastiasobustiaandeightycompoundshavebeenobtainedfromthesoftcoralSinulariainexPlicita.InthispaPerwewou1dliketoreportthestructurale…     

新型冠状病毒肺炎疫情的应对政策及评估体系研究

截至2021年2月,新型冠状病毒肺炎(COVID-19)疫情已经在全球近200个国家和地区造成超1亿人感染,累计超200万例死亡.各国政府、企业、民间组织和家庭个人,根据各自治理模式、经济机制、社会环境及生活方式,纷纷采取相应对策,减少病毒的传播和危害.回顾了人类历史上重大突发公共卫生事件,介绍了世界各国应对突发公共卫...     

Spectral separation of gaseous fluorocarbon mixtures and measurement of diffusion constants by F gas phase DOSY NMR

Diffusion-ordered (DOSY) NMR techniques have for the first time been applied to the spectral separation of mixtures of fluorinated gases by diffusion rates. A mixture of linear perfluoroalkanes from methane to hexane was readily separated at 25 °C in an ordinary experimental setup with standard DOSY pulse sequences. Partial separation of variously fluorinated ethanes was also achieved. The constants of self-diffusion of a set of pure perfluoroalkanes were obtained at pressures from 0.25 to 1.34 atm and temperatures from 20 to 122 °C. Under all conditions there was agreement within 20% of experimental self-diffusion constant D and values calculated by the semiempirical Fuller method.     

Synthesis and Applications of Nitrogen-Containing Heterocycles as Antiviral Agents

Viruses have been a long-term source of infectious diseases that can lead to large-scale infections and massive deaths. Especially with the recent highly contagious coronavirus (COVID-19), antiviral drugs were developed nonstop to deal with the emergence of new viruses and subject to drug resistance. Nitrogen-containing heterocycles have compatible structures and properties with exceptional biological activity for the drug design of antiviral agents. They provided a broad spectrum of interference against viral infection at various stages, from blocking early viral entry to disrupting the viral genome replication process by targeting different enzymes and proteins of viruses. This review focused on the synthesis and application of antiviral agents derived from various nitrogen-containing heterocycles, such as indole, pyrrole, pyrimidine, pyrazole, and quinoline, within the last ten years. The synthesized scaffolds target HIV, HCV/HBV, VZV/HSV, SARS-CoV, COVID-19, and influenza viruses.