城域综合业务接入网组网方案探讨

为了建设一个以大容量光纤传输网络为主体,以宽带多业务交换网为核心,以多元化综合接入为基础,支持端到端话音、数据、多媒体等各类增值业务的城域综合业务接入网,在分析了城域综合业务接入网的业务需求的基础上,提出了城域综合业务接入网的主要结构和城域传输网的组织方式。     

A network-based pharmacology study of active compounds and targets of Fritillaria thunbergii against influenza

Seasonal and pandemic influenza infections are serious threats to public health and the global economy. Since antigenic drift reduces the effectiveness of conventional therapies against the virus, herbal medicine has been proposed as an alternative. Fritillaria thunbergii (FT) have been traditionally used to treat airway inflammatory diseases such as coughs, bronchitis, pneumonia, and fever-based illnesses. Herein, we used a network pharmacology-based strategy to predict potential compounds from Fritillaria thunbergii (FT), target genes, and cellular pathways to better combat influenza and influenza-associated diseases. We identified five compounds, and 47 target genes using a compound-target network (C-T). Two compounds (beta-sitosterol and pelargonidin) and nine target genes (BCL2, CASP3, HSP90AA1, ICAM1, JUN, NOS2, PPARG, PTGS1, PTGS2) were identified using a compound-influenza disease target network (C-D). Protein-protein interaction (PPI) network was constructed and we identified eight proteins from nine target genes formed a network. The compound-disease-pathway network (C-D-P) revealed three classes of pathways linked to influenza: cancer, viral diseases, and inflammation. Taken together, our systems biology data from C-T, C-D, PPI and C-D-P networks predicted potent compounds from FT and new therapeutic targets and pathways involved in influenza.     

一种改进的Jacobi正交多项式的BP神经网络算法

 根据多项式理论,构造一种以Jacobi正交多项式作为隐层神经元激励函数的BP(back-propagation)神经网络模型.针对该网络,提出一种改进算法即隐层神经元数可快速确定的权值直接确定算法.首先介绍正交基函数和Jacobi多项式的定义,以及BP神经网络的基本原理.然后进行网络隐层数设计及其隐神经元数的确定,且设置各层连接权值、给出改进算法的步骤.最后,将其与传统矩阵迭代法和Levenberg-Marquardt训练算法进行比较.计算机实验结果表明,该算法具有比传统的BP迭代法更快的计算速度,并且能够达到更高的工作精度.     

Role of Tip60 tumor suppressor in DNA repair pathway

To prevent the damage caused by DNA strand breaks, eukaryotic cells have evolved a series of highly conserved DNA repair mechanisms. The ubiquitously expressed acetyltransferase, Tip60, plays a central role in ATM (ataxia-telangiectasia mutated) activation which is involved in DNA repair. Recent work uncovered a new mechanism of ATM activation mediated by Tip60 and demonstrated that histone methylation, specifically, trimethylation of histone H3, is a key factor in the process. Here, we review the current understanding of how Tip60 is activated and how it activates ATM in response to DNA damage.     

流量分布路由在无线网络中的应用

介绍了无线网络的概念、特点,以及无线局域网的协议标准和常见的无线网络的应用设备,并对流量分布路由在无线网络中的应用进行探讨,通过高速路由表查找算法及其改进流量分布路由让无线网络速度得到了提高.     

校园网上sFlow网络流量监控设计

随着网络规模的不断扩大,异构化程度的不断增高,网络带宽的成倍增长,网络变得日益复杂,为了在复杂环境下提供有质量保证的网络服务,采用sFlow流量采集技术在高速校园网内进行网络流量监控,减少了流量收集的数据量,同时又保证了数据可准确地用以进行网络流量监控.分析流量采集点在网络各层次的设置,并准确地对网络流量进行全面分析,根据实际需求采用2种sFlow系统组织方案,以实际应用细诉具体sFlow的设置,提出基于sFlow技术的全网流量监控.     

基于支持向量机的肤色滤波器

为了探测图像中的肤色像素,提出了一种新的方法-支持向量机（SVM：Support Vector Machine）方法.它是一种基于肤色的非特定人的面部定位方法,是非接触人机交互技术和机器视觉中的一个重要内容.实验结果表明,采用支持向量机方法较传统人工神经网络方法不仅有更高的探测准确性,而且具有更好的推广性能.由于SVM采用结构风险最小化（SRM：Structural Risk Minimization）准则,在最小化训练误差（经验风险）的同时,尽量缩小模型预测误差的上界,从而使模型有更好的泛化能力.