Bioorthogonal SERS Nanoprobes for Mulitplex Spectroscopic Detection,Tumor Cell Targeting,and Tissue Imaging

A surface‐enhanced Raman scattering (SERS) technique shows extraordinary features for a range of biological and biomedical applications. Herein, a series of novel bioorthogonal SERS nanoprobes were constructed with Gold nanoflower (AuNF) and Raman reporters, the signals of which were located in a Raman‐silent region of biological samples. AS1411 aptamer was also co‐conjugated with AuNF through a self‐assembled monolayer coverage strategy. Multiplex SERS imaging using these nanoprobes with three different bioorthogonal small‐molecule Raman reporters is successfully achieved with high multiplexing capacity in a biologically Raman‐silent region. These Raman nanoprobes co‐conjugated with AS1411 showed high affinity for tumor cells with overexpressed nucleolin and can be used for selective tumor cell screening and tissue imaging.     

自动化立体仓库均匀出库算法

本文结合某公司自动化立体仓库系统(AS RS)实施过程,分析研究了出库作业的相关因素,给出了一种有效的出库算法———均匀出库算法,算法主要包括获得客户优先级的算法,出库托盘序列号的算法,按巷道均衡、距离优先出库的算法,出库作业优先级的算法。     

公共图书馆无差别服务与社会包容

从图书馆社会包容职能的角度出发,对公共图书馆充分满足弱势群体读者的信息需求,实现无差别服务的必要性进行了研究。     

Ant colony approach to constrained redundancy optimization in binary systems

This paper presents an ant colony optimization algorithm to address the constrained redundancy allocation problem in order to maximize system reliability for complex binary systems. The constraints involved, though separable, are both linear and non-linear. We couple an adaptive penalty function with the basic ant colony approach to handle highly constrained problems and embed a local search technique to find still better locally optimal solutions. The proposed algorithm has been tested on a large number of problems, containing even up to 500 subsystems, with both fixed and randomly generated parameters. Experimental results demonstrate the advantage of the proposed algorithm to solve similar types of problems.     

Vulnerable Derivatives and Good Deal Bounds: A Structural Model

Abstract

We price vulnerable derivatives – i.e. derivatives where the counterparty may default. These are basically the derivatives traded on the over-the-counter (OTC) markets. Default is modelled in a structural framework. The technique employed for pricing is good deal bounds (GDBs). The method imposes a new restriction in the arbitrage free model by setting upper bounds on the Sharpe ratios (SRs) of the assets. The potential prices that are eliminated represent unreasonably good deals. The constraint on the SR translates into a constraint on the stochastic discount factor. Thus, tight pricing bounds can be obtained. We provide a link between the objective probability measure and the range of potential risk-neutral measures, which has an intuitive economic meaning. We also provide tight pricing bounds for European calls and show how to extend the call formula to pricing other financial products in a consistent way. Finally, we numerically analyse the behaviour of the good deal pricing bounds.     

Significance of plaque morphology in modifying flow characteristics in a diseased coronary artery: Numerical simulation using plaque measurements from intravascular ultrasound imaging

The paper deals with numerical investigation of the effect of plaque morphology on the flow characteristics in a diseased coronary artery using realistic plaque morphology. The morphological information of the lumen and the plaque is obtained from intravascular ultrasound imaging measurements of 42 patients performed at Cleveland Clinic Foundation, Ohio. For this data, study of Bhaganagar et al. (2010) [1] has revealed the stenosis for 42 patients can be categorized into four types – type I (peak-valley), type II (ascending), type III (descending), and type IV (diffuse). The aim of the present study is to isolate the effect of shape of the stenosis on the flow characteristics for a given degree of the stenosis. In this study, we conduct fluid dynamic simulations for the four stenosis types (type I–IV) and analyze the differences in the flow characteristics between these types. Finely refined tetrahedral mesh for the 3-D solid model of the artery with plaques has been generated. The 3-D steady flow simulations were performed using the turbulence (k–ε) model in a finite volume based computational fluid dynamics solver. The axial velocity, the radial velocity, turbulence kinetic energy and wall shear stress profiles of the plaque have been analyzed. From the axial and radial velocity profiles results the differences in the velocity patterns are significantly visible at proximal as well as distal to the throat, region of maximum stenosis. Turbulent kinetic energy and wall shear stress profiles have revealed significant differences in the vicinity of the plaque. Additional unsteady flow simulations have been performed to validate the hypothesis of the significance of plaque morphology in flow alterations in diseased coronary artery. The results revealed the importance of accounting for plaque morphology in addition to plaque height to accurately characterize the turbulent flow in a diseased coronary artery.     

基于过滤机制的抑制BGP路由表增长的方法

经过对BGP路由表进行分析,发现在BGP路由表中包含大量前缀长度大于地址分配策略所规定值的路由·给出了一种减缓路由表增长的方法,该方法基于前缀长度对路由进行过滤·对前缀长度大于地址分配策略所规定值的路由,只允许其在指定的距离范围内被通告,一旦该路由穿越了指定数目的AS,它就将被过滤掉,不再被通告·通过修改BGP协议,为其增加一个新的属性来记录被过滤路由的最大通告距离,实现对路由过滤·通过模拟实验证明所给方法可行,对抑制路由表增长效果明显·     

Biotransformation of 20(R)-panaxatriol by the fungus Aspergillus flavus Link AS 3.3950

Microbial transformation of 20(R)-panaxatriol by the fungus Aspergillus flavus Link AS 3.3950 was performed. Four new (1–4), along with two previously reported metabolites (5 and 6), were obtained. Their chemical structures were elucidated on the basis of extensive spectroscopic analyses. Furthermore, the inhibitory effects of those compounds on K562/ADR, Du-145, Hela, MCF-7 and HepG2 cell lines were evaluated by MTT assay. Among them, compound 15β-hydroxy-20(R)-panaxatriol (4) exhibited selective inhibitory effects on human leukaemic progenitor cells K562/ADR through arresting cell cycle, which was associated with obvious decrease of cyclin B1, cyclin D1 and cyclin-dependent kinase (CDK) 1/2/4/6 protein expression.     

通过公平“悦”读促进社会融合——兼论图书馆的弱势群体服务

公平"悦"读,意味着人们公平地享有读书的权利,其中包括弱势群体迫切需求的公平阅读权利。阐述了图书馆关注弱势群体的历史渊源,探讨了图书馆为弱势群体服务的举措,分析了图书馆为弱势群体服务的不足。     

多孔陶瓷板城市燃气预混燃烧的数学模拟

对人工均布小孔的多孔陶瓷板内城市燃气的预混燃烧进行了研究．讨论了作为目前上海城市煤气的主要成分ＣＯ、Ｈ２、ＣＨ４的反应动力学及其参数——活化能、频率因子等,建立了反应动力学方程．通过理论分析推导出燃气－空气预混气体的连续性方程、组分方程、能量方程、状态方程及多孔陶瓷的能量方程,建立了多孔陶瓷板中城市煤气预混式燃烧的数学模型．由数值计算得到多孔陶瓷板的板内固体温度分布,并与实验数据进行比较