波片提高声光Q开关关断Nd∶YAG激光能力研究

采用琼斯矢量变换的方法，分析了四分之一波片对入射椭圆偏振光偏振面的变换过程.结合声光相互作用理论和声光介质熔石英在平行和垂直于声场的两个方向具有不同声光优值的特性，理论推导了腔内引入四分之一波片后声光Q开关的布喇格衍射效率公式，计算模拟得出引入四分之一波片能够有效地提高声光Q开关关断连续Nd∶YAG激光的能力.在理论分析的基础上进行了实验验证，实验结果与理论分析符合得很好.     

吖啶橙-细胞DNA荧光抑制法初步筛选抗癌药物的研究

以二倍体鼠肝细胞为标准细胞，用荧光探针吖啶橙（ＡＯ）示踪药物／细胞ＤＮＡ的作用而提出了一种用Ｈａｄａｍａｒｄ变换显微荧光图象分析法初步筛选抗癌药物的新方法．对Ｄ－氨基葡萄糖的３ｄ过渡金属的配合物、Ｄ－氨基葡萄糖与β－萘酚醛的Ｓｃｈｉｆ碱及其与３ｄ过渡金属的配合物和它们分别与甘氨酸形成的混配物共四个系列２２种化合物与细胞ＤＮＡ的作用进行了研究，结果表明：Ｃｏ（Ⅲ）ＮＧ，Ｃｏ（Ⅱ）ＮＧ，ＣｕＮＧ，ＣｕＧｌｕ，ＮｉＮＧ，ＣｕＧｌｕＧ，Ｆｅ（Ⅲ）ＮＧ７种化合物有明显的抗癌活性，其中ＣｕＧｌｕ对Ｇ０期细胞更为敏感．     

茶多酚对Hep-G2细胞活性及形态的影响

大量研究表明,长期饮茶尤其绿茶者,可大大降低各种癌变的发病率,而且对多种体内外肿瘤具有直接杀伤作用.作者通过采用不同浓度的茶多酚作用于体外培养的肝癌细胞株Hep-G2细胞,初步探讨茶多酚对Hep-G2细胞的凋亡作用.采用MTT法(噻唑蓝比色法)和AO-PI(吖啶橙-碘化丙啶)双重荧光染色法研究了茶多酚诱导Hep-G2细胞株的凋亡作用.MTT法研究结果表明,在一定的浓度范围内,茶多酚对Hep-G2细胞有明显的抑制作用,且存在良好的剂量效应关系,随着茶多酚浓度的升高,其对Hep-G2细胞的抑制率也升高.Hep-G2细胞经茶多酚作用后,细胞形态发生明显的变化,可见凋亡小体,荧光强度增强,细胞呈现凋亡现象.茶多酚在体外对Hep-G2细胞的增殖具有抑制作用,诱导其发生凋亡.研究结果为茶多酚的进一步开发应用奠定理论基础.     

中药"龙泉复方"的不同配伍对肿瘤细胞系HepG-2和EC-1增殖的影响

通过MTT(四甲基偶氮唑盐)法绘制细胞增殖曲线观察药物对肝癌细胞系HepG-2和食管鳞癌细胞系EC-1细胞增殖的影响,用荧光染色法进一步确定"龙泉复方"有效成分诱导细胞凋亡的较佳配伍及其有效作用浓度范围.结果表明:对抑制HepG-2细胞增殖有效作用的浓度:七味单方(马钱子、山慈菇、喜树果、龙葵、石上柏、青黛、紫菀)浸膏...     

Anomalous coordination behaviour of 6‐methyl‐2‐oxo‐1,2‐dihydroquinoline‐3‐carboxaldehyde‐4(N)‐substituted Schiff bases in Cu(II) complexes: Studies of structure,biomolecular interactions and cytotoxicity

A series of copper(II) complexes containing 6‐methyl‐2‐oxo‐1,2‐dihydroquinoline‐3‐carboxaldehyde‐derived Schiff bases have been synthesized and characterised using various analytical and spectroscopic techniques. X‐ray crystallographic analysis confirmed the true coordinating nature of ligands with copper ion. The ligands exhibited ONS tridentate neutral and monobasic coordination. The spectroscopic results evidenced the interaction of the ligands and their copper(II) complexes with nucleic acid/serum albumin. Further, the complexes showed significant activity against human skin cancer cell line (A431) and less toxicity against human keratinocyte cell line (HaCaT). Acridine orange/propidium iodide dual staining studies indicated that the major cause of A431 cell death was through necrosis. By comparing the biological activity of all the ligands, Cu(II) complexes and standard (cisplatin), complex [Cu(H‐6MOQtsc‐Ph)(H₂O)]?NO₃ ( 4 ) exhibited better activity than others, the activity being arranged as follows: 4  >  1  > cisplatin >  3  >  2 .     

自适应光学系统控制效果分析的功率谱方法

 用H-S 波前探测器得到校正前后波前相位时间功率谱, 分析了自适应光学控制系统对大气湍流扰动波前的时域校正效果。用这种方法比较了61单元自适应光学系统分别采用P-I 控制算法和Smith 纯滞后补偿控制算法对实际大气湍流扰动波前进行补偿实验时的校正效果。     

Improvement of parallelization performance of GAMESS: global sum and (semi-)direct integral calculation in multireference perturbation calculation

Performance benchmark tests of the multireference perturbation theory (MRPT2) calculation in the GAMESS suite of programs have been performed on a 128-node PC cluster system. The benchmark results point to two kinds of problems with GAMESS: network delay and slow access to disk files. To overcome these bottlenecks, we employ (semi-)direct atomic orbital integral calculations and a new algorithm for the "global sum" operation. These modifications produce remarkable performance improvements, especially in the 128-node PC cluster system, which was almost twice as fast in our version as in the original version. The modification of "global sum" also improved the performance of other types of molecular orbital calculations in GAMESS, such as density functional theory.     

LD侧泵的声光调Q Nd∶YAG/KTP人眼安全激光器

为获得人眼安全的激光,在一个由激光二极管（LD）阵列侧泵、声光调Q的Nd∶YAG激光器谐振腔中放置一非临界相位匹配的KTP晶体,形成了一个内腔式光学参量振荡器,实现了准连续的1.57 μm激光振荡.通过对单谐振光学参量振荡器阈值公式进行讨论,采用了平凹腔的结构和尽可能短的光学参量振荡器腔长,有效地降低了光学参量振荡器的泵浦阈值.测量了不同声光重复率和不同透射率输出镜下光学参量振荡器输出的各项特性参量.分析了声光重复率和输出镜的透过率对光学参量振荡器的泵浦阈值和输出脉冲波形的影响,并对实验中出现的饱和现象作了解释.当泵浦电流14.5A,声光重复率10 kHz,光学参量振荡器输出镜透过率15%时,在保持单脉冲输出的情况下,获得了1.57 μm激光的最高平均功率输出值1.748 W.     

AO方法在Jini平台DVE下的协同服务设计中的应用

本文介绍了AO(Aspect Oriented)开发方法在设计Jini平台的分布式虚拟环境(DistributedVirtualEnviron ment,DVE)下的协同服务中的应用.通过剖析虚拟教室应用场景,从AO角度,归纳出协同应用系统中最典型的Aspects,并给出了协同服务实现中关键的组件与Aspects组合的动态编织机制,以及编织组件与Aspects的中间件层的概要设计.