5位1.5GHz采样频率的Flash ADC的设计及数字后台校正实现

基于TSMC 0.18μm工艺设计了一个单通道5位,1.5GHz Flash模数转换器(ADC),该ADC通过改进跟踪保持电路和采用动态比较器结构实现了数据的高速转换.仿真结果表明,当输入信号达到奈奎斯特频率时,信号与噪声加谐波失真比(SNDR)为24.04dB,无杂散动态范围(SFDR)为29.97dB.为进一步提高此ADC的性能,消除非线性,基于Volterra级数搭建了数字后台校正模型.对比仿真结果,校正后谐波明显下降,SNDR提高了4.91dB,SFDR提高了6.94dB,有效位数提高了约0.82位.     

一种高精度CMOS温度传感器的设计

介绍了一种基于55nm CMOS工艺实现的温度传感器。该温度传感器包括了温度传感电路与SAR ADC两个部分。温度传感电路产生与温度正相关的模拟电压,再通过SAR ADC进行模数转换从而得到代表温度信息的数字信号。ADC采用改进的R-2R DAC结构,省略了运算放大器,消除运放失调对温度精度的影响。仿真结果表明,在1.2V的供电电源下,该温度传感器在-20℃~100℃的温度范围内,温度分辨率为0.2℃,温度精度为+0.32℃。     

ADC border effect and suppression of quantization error in the digital dynamic measurement

The digital measurement and processing is an important direction in the measurement and control field. The quantization error widely existing in the digital processing is always the decisive factor that restricts the development and applications of the digital technology. In this paper, we find that the stability of the digital quantization system is obviously better than the quantization resolution. The application of a border effect in the digital quantization can greatly improve the accuracy of digital processing. Its effective precision has nothing to do with the number of quantization bits, which is only related to the stability of the quantization system. The high precision measurement results obtained in the low level quantization system with high sampling rate have an important application value for the progress in the digital measurement and processing field.     

用于微悬臂梁红外焦平面读出电路的片上ADC设计

设计了一种用于微悬臂梁红外焦平面读出电路的片上 ADC。该 ADC 采用流水线结构实现, 采用带溢出检测的多位第一级和后级功耗逐级缩减的方案优化系统功耗, 提高线性度。该设计采用 0.35 μm 的 CMOS 工艺流片验证。测试结果表明: 5V 电源电压、10M 采样率时电路总功耗为98 mW, 微分非线性和积分非线性分别为 -0.8/0. 836 LSB 和 - 0. 9 / 1. 6 LSB; 输入频率为 1 MHz 时, SFDR 和 SNDR 分别为82 和 67 dB。     

单片机在智能充电器中的应用

利用ＡＴ８９Ｃ５１、ＡＤＣ０８０９ 为主构成一个自动化程度较高的充电器．它对电池具有温度、－ ΔＶ、终止电压、短路、开路等多种检测功能,同时具有结构简单,可靠性高等特点．     

电感耦合等离子体原子发射光谱(ICP-AES)法测定ADC12中硅

在微波消解仪中以氢氧化钠溶解试样,然后滴加过氧化氢,使得铸造铝ADC12中的硅完全溶解,并采用电感耦合等离子体原子发射光谱(ICP-AES)法测定,硅的质量百分数平均值为10.31％的情况下,标准偏差0.09％,相对标准偏差(RSD)为0.83％.对比了国家标准方法中加热板消解法与微波消解法对硅加标回收率的影响,加热板消解法的加标回收率低于微波消解法,微波消解法辅助前处理样品,促使样品在短时间内反应完全,实验步骤简便,结果满意.     

Pipeline ADC的噪声与采样电容的关系

介绍了Pipeline ADC噪声与电容的关系及减小噪声的方法,并以10位ADC为例通过噪声计算电容．ADC的主要噪声源是量化噪声和热噪声．量化噪声主要决定ADC的精度．热噪声限制了ADC的信噪比,是提高精度的主要瓶颈．可以通过增大电容来减小．     

混合信号SoC联合测试方案

混合信号片上系统(SoC)模拟核的测试是SoC测试的难点之一,常用片上数模转换器(DAC)、模数转换器(ADC)配合模拟核进行测试。本文对于片上DAC、模拟核、ADC同时待测的情况,基于模拟核的振荡测试、ADC柱状图测试和DAC脉宽测试等方法,提出联合测试方案。将重构模拟核产生的三角波振荡信号,分别作为ADC柱状图测试和DAC脉宽测试的激励,并引入ADC和DAC的直连测试作为补充,构建三者两两之间的联合测试。该方案在对电路进行少量重构的条件下,自生成并复用测试激励,可实现对单故障的定位并解决双故障掩盖问题。     

多色焦平面和图像融合SoC实现技术的研究

大规模、智能化的多色焦平面阵列探测器和高性能、高集成度的SoC技术是未来发展的方向。对多色焦平面的概况、发展和关键技术进行了分析。为了能够更有效的利用信息,把由多色焦平面探测器输出的,并经天然配准的各波段图像进行了融合处理。详细介绍了现有的多种图像融合算法、模型、SoC和高速处理硬件平台的研究情况以及若干新进展。     

Current Analytical Strategies for Antibody–Drug Conjugates in Biomatrices

Antibody–drug conjugates (ADCs) are a new class of biotherapeutics, consisting of a cytotoxic payload covalently bound to an antibody by a linker. Ligand-binding assay (LBA) and liquid chromatography-mass spectrometry (LC-MS) are the favored techniques for the analysis of ADCs in biomatrices. The goal of our review is to provide current strategies related to a series of bioanalytical assays for pharmacokinetics (PK) and anti-drug antibody (ADA) assessments. Furthermore, the strengths and limitations of LBA and LC-MS platforms are compared. Finally, potential factors that affect the performance of the developed assays are also provided. It is hoped that the review can provide valuable insights to bioanalytical scientists on the use of an integrated analytical strategy involving LBA and LC–MS for the bioanalysis of ADCs and related immunogenicity evaluation.