全文获取类型
收费全文 | 194626篇 |
免费 | 13592篇 |
国内免费 | 26136篇 |
专业分类
化学 | 117093篇 |
晶体学 | 3268篇 |
力学 | 3580篇 |
综合类 | 1302篇 |
数学 | 17620篇 |
物理学 | 35305篇 |
综合类 | 56186篇 |
出版年
2024年 | 437篇 |
2023年 | 2074篇 |
2022年 | 4534篇 |
2021年 | 4573篇 |
2020年 | 5083篇 |
2019年 | 4815篇 |
2018年 | 4188篇 |
2017年 | 5790篇 |
2016年 | 6110篇 |
2015年 | 5830篇 |
2014年 | 7756篇 |
2013年 | 13070篇 |
2012年 | 12334篇 |
2011年 | 11753篇 |
2010年 | 9867篇 |
2009年 | 12229篇 |
2008年 | 12424篇 |
2007年 | 13960篇 |
2006年 | 12761篇 |
2005年 | 11124篇 |
2004年 | 10280篇 |
2003年 | 8585篇 |
2002年 | 9003篇 |
2001年 | 6239篇 |
2000年 | 5786篇 |
1999年 | 5091篇 |
1998年 | 4114篇 |
1997年 | 3532篇 |
1996年 | 3026篇 |
1995年 | 2747篇 |
1994年 | 2523篇 |
1993年 | 2138篇 |
1992年 | 1910篇 |
1991年 | 1505篇 |
1990年 | 1189篇 |
1989年 | 1133篇 |
1988年 | 881篇 |
1987年 | 626篇 |
1986年 | 475篇 |
1985年 | 380篇 |
1984年 | 343篇 |
1983年 | 180篇 |
1982年 | 281篇 |
1981年 | 272篇 |
1980年 | 272篇 |
1979年 | 258篇 |
1978年 | 228篇 |
1977年 | 176篇 |
1976年 | 139篇 |
1973年 | 92篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
P. R. Latthe P. S. Shinge Bharati V. Badami P. B. Patil S. N. Holihosur 《Journal of Chemical Sciences》2006,118(3):249-256
3-[4-(Azidocarbonyl)]phenylsydnone (2) obtained from 3-(4-hydrazinocarbonyl) phenylsydnone (1) on Curtius rearrangement with alcohols, water and amines afforded the corresponding carbamates (3a-h), 4,4′-(sydnone-3-yl) diphenyl urea (4) and 4-(heterocyclyl)phenyl ureas (5a-l). Compounds (5a-l) on one-pot ring conversion yielded the 1,3,4-oxadiazolin-2-one derivatives (6a-l), which on reaction with N2H4 gave the 4-amino-1,2,4-triazolin-3-ones (7a-l). All these compounds exhibited moderate antimicrobial activity against the few microbes tested. The carbamates have been
found to be more toxic against fourth instar larvae ofAedes aegypti, in particular, then-butyl derivative (3e). 相似文献
102.
What Is Its Real Existing Form?——Theoretical and Experimental Studies on 2-Mercaptobenzothiazole 总被引:1,自引:0,他引:1
1 INTRODUCTION The study of heterocyclic molecules with aroma- tic rings and their absorptions on metals is of con- siderable importance from both theoretical and te- chnological points of view. These molecules are in- teresting because of their applications as corrosion inhibitors and flotation collectors, and their abilities to form self-assembly layers[1]. 2-Mercaptobenzo- thiazole (C7H5NS2, in the following MBT) is an important heterocyclic molecule, which can be used as corrosion … 相似文献
103.
Science Letters: A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen 下载免费PDF全文
It has been proposed that activation of Toll-like receptors (TLRs) plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 (TLR2) ligand, Pam3CSK4, has been reported to modulate the balance of Th1/Th2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen (HDM). Mice were sensitized and challenged with Dermatophagoidesfarinae allergen (Der f), and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid (BALF). Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that IFN-7 released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases. 相似文献
104.
基于GM(1,1)模型的某高校招生人数预测 总被引:1,自引:0,他引:1
分析了近年来我国高校招生人数的变化趋势,并利用GM(1,1)模型对某高校2008年的招生人数进行了预测.从而为高校招生人数决策提供了依据。 相似文献
105.
随着信息时代的到来,互联网和多媒体技术迅猛发展,数字多媒体信息在网上传播越来越便捷,同时也带来了信息安全的隐患问题。小波变换具有良好的时频特性且小波的多分辨分析与人眼视觉特性是一致的。在小波域对图像进行分解,可以根据HVS特性更好地隐藏信息,解决信息安全的问题。 相似文献
106.
107.
《科学通报(英文版)》2008,(19)
The purposes of this research were to study the stable expression of exogenous gene encoding therapeutic protein in attenuated Salmonella typhimurium, observe the metabolism of oral gene vaccine carried by attenuated Salmonella typhimurium in BALB/c mouse, and investigate the feasibility of prevention and treatment of tumors by the recombinant bacteria. Recombinant plasmid pcDNA3.1 VEGFR2(n1-7) was transformed into competent attenuated Salmonella typhimurium SL3261 to develop oral DNA vaccine SL3261-pcDNA3.1 VEGFR2(n1-7). To observe whether the exogenous gene can be expressed in the recombinant bacteria, PCR was performed to amplify the CMV promoter of the eukaryotic expression vector as the proof of stable expression of exogenous protein; transmission elec- tron microscopy (TEM) was applied to observe the morphology of the recombinant bacteria to confirm that the exogenous gene has no impact on the growth of the bacteria, and then BALB/c mice were immunized with the gene vaccine. After inoculation of the gene vaccine, the recombinant bacteria SL3261 could be detected in the tissues such as small intestine, colon, liver and spleen. And then, mice in each group were challenged with tumor cells. The results of animal experiment showed that tumor growth of the mice in experimental group was inhibited and survival time of immunized mice was prolonged compared with control groups. A higher lymphocyte infiltration in tumors from animals treated with DNA vaccine was observed. Immunohistochemical analysis of tumor samples revealed an en- hanced accumulation of CD8 cytotoxic T lymphocytes, as well as an increase in CD4 cells in the tumors of animals treated with the oral gene vaccine compared to tumors from control group mice. Ultrastructure of the tumor tissue showed that tumor cells in the samples of the immunized mice were well-differentiated. Our research confirmed that the exogenous gene can be stably expressed in the attenuated Salmonella typhimurium and has no impact on the growth of the recombinant bacteria; the exogenous gene can de delivered to the host by attenuated Salmonella typhimurium to produce anti-tumor effect with no obvious cytotoxity to the host. In this study, it is established that attenuated Salmonella typhimurium could be used as a vector for oral gene vaccine, and our study provided a theoretical basis for the body distribution and the metabolism of the recombinant bacteria. This strategy may provide a simple, safe and effective way for the prevention and treatment of tumors. 相似文献
108.
109.
Various 2-substituted indoles were prepared by heteroannulation of o-iodoanilines and terminal alkynes in a one-pot reaction with a Pd(II)-NaY zeolite catalyst. The product formation largely depended on the solvent, base, and reaction temperature. The recycled catalyst showed good reusability in the heteroannulation reaction. 相似文献
110.
R. J. Saykally K. M. Evenson D. A. Jennings L. R. Zink A. Scalabrin 《International Journal of Infrared and Millimeter Waves》1987,8(6):653-662
Twenty new cw FIR laser lines in CD3OH, optically pumped by a CO2 laser, are reported. The frequencies of 39 of the stronger laser lines were measured relative to stabilized CO2 lasers with a fractional uncertainty, as determined by the reproducibility of the FIR frequency itself, of 2 parts in 107.Contribution of the U.S. Government, not subject to copyright. 相似文献