亚砜类萃取剂萃取青霉素G的工艺研究

系统研究了亚砜类萃取剂石油亚砜和二异辛基亚砜萃取青霉素Ｇ的性能。在平衡研究的基础上确定了适宜的革萃和反萃条件，以此为基础进行了萃取串级和工艺台架试验。结果表明，分别由石油亚砜、二异辛基亚砜与稀释剂磺化煤油组成的萃取体系对青霉素Ｇ的革取性能均优于现有的醋酸丁酯体系，且二异辛基亚砜体系比石油亚砜体系更好。由于它们的低水溶性，因此不必从废酸水中回收革取剂，使操作简化、能耗降低。实验中还发现，当亚砜、胺组合使用时，有明显的协萃效应。     

一种青霉素发酵过程补料优化的新方法

将青霉素发酵工艺与最优控制算法相结合，提出一种二步优化法优化青霉素发酵过程．用该方法得出的优化结果指导青霉素发酵工业生产实际过程取得了满意的效果，证明用本方法求得的优化结果可弥补生化过程动力学模型的一些不足，寻求出较适合工业生产实际的优化结果，     

Pr（IV）在二乙三胺五乙酸水溶液中稳定性的研究

Ｐｒ（Ⅳ，Ⅲ）碱式碳酸盐溶于一定浓度和ｐＨ值的三乙三胺五乙酸（ＤＴＰＡ）水溶液中，形成黄色Ｐｒ（Ⅳ）－ＤＴＰＡ配合物。测得该配合物组成比Ｐｒ（Ⅳ）：ＤＴＰＡ＝１：１。该配合物溶液在２７０ｎｍ附近有一特征宽带吸收峰。Ｐｒ（Ⅳ）在ＤＴＰＡ水溶液中的动力学稳定性与无螯合剂时相比较，至少提高了１０＾７倍，Ｐｒ（Ⅳ）的还原为拟一级反应。     

Co（Ⅱ）对青霉素酰化酶的激活作用

文中报道Ｃｏ（Ⅱ）对巨大芽孢杆菌青霉素酰化酶的激活作用。并用荧光光谱法对其可能的机理进行了研究。结果表明：Ｃｏ（Ⅱ）对青霉素酰化酶具有荧光猝来作用，但并没有引起整个酶分子空间构象的变化，而是与活性部位的某些基团发生了络合作用，有利于底物的诱导契合从而引起酶活力的提高。     

Anion-exchangeable inorganic-organic hybrid materials synthesized without using templates

Inorganic-organic hybrid materials have been obtained at room temperature in aqueous solution without using the templates of surfactants. The materials are carefully characterized by anion-exchange measurement, elements analysis, X-ray diffraction, and infrared spectroscopy. Notably, the anion-exchange capacity of the samples (3.9mmol.g^-1) is even higher than anion-exchangeable resins. Interestingly, both small and large anions could be easily exchanged into the samples due to the plasticity of the samples, along with the phase transition.     

Research of Inclusion Complexation of 4,4＇-Thiodiphenol Effected by β-Cyclodextrin in Aqueous Solutions and the Effect on Photodegradation

The inclusion behavior of 4, 4＇ -Thiodiphenol （TDP）, a typical bisphenol and endocrine disruptor, reacts with β-cyclodextrin （β-CD） in aqueous solutions has been investigated by means of UV absorption spectrum and quantum-chemical calculation with Gaussian 98 software. The results show that the inclusion behavior of TDP is quite different in acidic solutions （pH 5.9） from that in alkaline solutions （pH 10.0）. This behavior difference is attributed to the different formula structures in aqueous solutions at acidic and alkaline pH values that are demonstrated by quantum- chemical modeling and calculation. TDP forms a 1 ： 1 fl-CD inclusion complex in aqueous solutions. The equiiibrium constant K was calculated to be 553.49 L/mol at pH 5.9 and 1 318.20 L/mol at pH 10.0 respectively for the inclusion complex reaction by using the modified Benesi-Heldbrand equation. After inclusion TDP＇s structure is changed especially at the inclusion part with the bond order becoming larger, which results in inhibitive photodegradation during direct photooxidation and H2O2 assisted photooxidation.     

水溶液中取代乙酸的量化研究

本文应用量子化学理论，超分子方法和ＣＮＤＯ／２计算了方法，结合回归分析研究水溶液中取代乙酸的与分子的电子结构关系，从而从量化角度解释水溶液中取代乙酸的酸性及其变化规律。结果表明，水溶液中取代乙酸的氢原子电荷ＱＨ与ＰＫａ有很好的相关关系，羧酸的酸性可用ＱＨ来衡量，羧基氢原子与水分子形成氢键是影响水溶液中羧酸酸性变化的主要因素。     

静脉输入青霉素引起剧烈腰痛1例

1临床资料患者腾某，男性，30岁。发烧咽癌2天于97年5月20日就诊，体检：体温30．8℃，咽部充血，双侧扁桃体Ⅲ°，有少许脓点，无伪膜，心肺及腹部未见异常，白细胞总数14×109／L，中性粒细胞89％，诊断：急性扁桃体炎，予以青霉素钠800万单位日一次静点，（青霉素钠为华北制药股份有限公司生产批号：9702226）三天后病人体温恢复正常，咽部仍充血扁桃体脓点消失，为巩固疗效第四天继续静点上述剂量青霉素钠，当静点进行至5分钟时病人自述腰痛，随着静点进行至10分钟时病人腰痛剧烈，伴有出冷汗，面色苍白，立即停止流点。体检：血压：14…