Modulation of electroencephalograph activity by manual acupuncture stimulation in healthy subjects:An autoregressive spectral analysis

To investigate whether and how manual acupuncture(MA) modulates brain activities,we design an experiment where acupuncture at acupoint ST36 of the right leg is used to obtain electroencephalograph(EEG) signals in healthy subjects.We adopt the autoregressive(AR) Burg method to estimate the power spectrum of EEG signals and analyze the relative powers in delta(0 Hz-4 Hz),theta(4 Hz-8 Hz),alpha(8 Hz-13 Hz),and beta(13 Hz-30 Hz) bands.Our results show that MA at ST36 can significantly increase the EEG slow wave relative power(delta band) and reduce the fast wave relative powers(alpha and beta bands),while there are no statistical differences in theta band relative power between different acupuncture states.In order to quantify the ratio of slow to fast wave EEG activity,we compute the power ratio index.It is found that the MA can significantly increase the power ratio index,especially in frontal and central lobes.All the results highlight the modulation of brain activities with MA and may provide potential help for the clinical use of acupuncture.The proposed quantitative method of acupuncture signals may be further used to make MA more standardized.     

Characterizing neural activities evoked by manual acupuncture through spiking irregularity measures

The neural system characterizes information in external stimulations by different spiking patterns. In order to examine how neural spiking patterns are related to acupuncture manipulations, experiments are designed in such a way that different types of manual acupuncture （MA） manipulations are taken at the ＇Zusanli＇ point of experimental rats, and the induced electrical signals in the spinal dorsal root ganglion are detected and recorded. The interspike interval （ISI） statistical histogram is fitted by the gamma distribution, which has two parameters： one is the time-dependent firing rate and the other is a shape parameter characterizing the spiking irregularities. The shape parameter is the measure of spiking irregularities and can be used to identify the type of MA manipulations. The coefficient of variation is mostly used to measure the spike time irregularity, but it overestimates the irregularity in the case of pronounced firing rate changes. However, experiments show that each acupuncture manipulation will lead to changes in the firing rate. So we combine four relatively rate- independent measures to study the irregularity of spike trains evoked by different types of MA manipulations. Results suggest that the MA manipulations possess unique spiking statistics and characteristics and can be distinguished according to the spiking irregularity measures. These studies have offered new insights into the coding processes and information transfer of acupuncture.     

幽门螺杆菌与上消化道疾病关系的临床研究

目的研究幽门螺杆菌与上消化道疾病的关系及致病机理.方法进行临床病例分析及相关病理、毒理实验.结果研究表明,幽门螺杆菌与慢性胃炎、消化性溃疡、消化道肿瘤等消化道疾病有密切的关系.结论功能性基因组可能填补我们对幽门螺杆菌感染发病机制理解的许多空白,加速新疗法的产生.     

多胺基针刺布的制备及其在H2S去除中的应用

为了解决含硫化氢(H_2S)废气的高效净化问题,直接以腈纶针刺布为原材料,通过一步反应制备了多胺基针刺布,测得其交换容量为5.9 mmol/g,并用红外光谱和热分析技术对其进行了表征;研究了碱液存在下多胺基针刺布对H_2S的去除性能及气体流量、碱液浓度、增重率、氧含量和H_2S浓度等因素的影响,结果表明碱液和多胺基针刺布的协同作用对气体中的H_2S具有优异的去除性能.吸附饱和的多胺基针刺布可用碱液再生,且再生后性能无明显变化,在所设定实验条件下,针刺布处理容量和碱吸收容量分别稳定在30.6 mg/g和697.2 mg/g左右.     

毫针密集型触骨针法治疗髌下脂肪垫炎113例探讨

观察毫针密集型触骨针法治疗髌下脂肪垫炎的临床疗效。将113例患者随机分为2组。治疗组57例采用毫针密集型触骨针法治疗。对照组56例采用普通针刺治疗;总有效率治疗组为92.98%,对照组为69.64%,2组比较,差异有显著性意义(P0.05)。毫针密集型触骨针法治疗髌下脂肪垫炎临床疗效显著。     

针刺配合超声波治疗骨折术后组织粘连的临床研究

观察针刺配合超声波疗法治疗骨折术后组织粘连的临床疗效,并探讨其作用机理。将骨折术后有明显组织粘连的患者76例随机分为两组,分别为针刺组38例和超声组(针刺配合超声)38例进行治疗。治疗前后两组根据临床疗效进行评定。结果显示:针刺组治愈率为84.2%,超声组治愈率为94.7%。得出结论:针刺配合超声波疗法能够明显改善患者骨折术后组织粘连,提高术后关节活动度,以提高生活质量。     

针刺过程中大脑功能性网络特性的演化

根据脑电图数据建立大脑功能性网络, 并使用功能性网络图、 聚类系数、 熵等复杂网络分析方法对5组实验数据形成的功能性网络进行分析, 给出了针刺治病的内在机理. 分析结果表明: 在针刺前、 中、 后网络结构和网络中各节点间的相关性有明显变化;  针刺可以影响高级神经中枢的放电活动, 增强大脑各功能区的信息传递.     

蒙医药治疗糖尿病临床研究进展

对近10年来蒙医药防治糖尿病的临床研究进展进行了综述,阐明了蒙医药在糖尿病治疗方面有独特的理念和优势,并提出存在的问题.     

针刺治疗缺血性脑血管病的研究

针对针刺治疗缺血性脑血管病的研究机理进行阐述,指出这一治疗手段的创新性,解决了关键科学问题,开展了针刺治疗缺血性中风病临床疗效评价及机理研究。     

针刺治疗混合痔术后疼痛的临床疗效观察

观察针刺对于混合痔术后疼痛的临床疗效;将80例混合痔术后患者随机分为针刺治疗组和西药对照组,针刺治疗组在常规换药的基础上采用针刺治疗,西药对照组在常规换药的基础上采用肌注强痛定。观察两组的疼痛程度;治疗组对减少术后疼痛明显优于对照组(p0.05);针刺可以明显减轻混合痔术后的疼痛。