赤魟软骨新生血管抑制组分的制备及其活性的初步研究

以赤魟软骨为原料,对赤魟软骨中新生血管抑制组分的提取方法及其生物学活性进行了初步研究。采用盐酸胍抽提、冷冻离心、透析、冷冻干燥等方法,得到分子量为3～300 kDa的活性组分,研究结果表明:赤魟软骨提取物显著地抑制了鸡胚绒毛尿囊膜血管的生成,并且抑制效果具有一定的浓度依赖性。     

Establishment of the model of vascular endothelial cell membrane chromatography and its preliminary application

A model of vascular endothelial cell membrane chromatography was established by using an ECV304 cell membrane stationary phase (ECV304 CMSP) prepared by immobilizing the ECV304 cell membrane onto the surface of silica carrier. The surface and chromatographic characteristics of ECV304 CMSP were studied. The active component from Caulophyllum robustum was screened by using the model of vascular endothelial cell membrane chromatography. The interaction between the active component and membrane receptor was determined by using a replace experiments. The effect of the active component was tested by using tube formation of ECV304 cell. The results indicated that the model of ECV304 cell membrane chromatograph (ECV304 CMC) can stimulate the interaction between drug and receptor in vitro and the retention characteristics of taspine as active component was similar to that of model molecule in the model of ECV304 CMC. And therefore, taspine acted on VEGFR2 and inhibited the tube formation of ECV304 cell induced by VEGF. This model can be used to screen definite active component as a screening model.     

血管内皮细胞生长因子在损伤修复中的作用

近年研究显示血管内皮细胞生长因子能够促进局部组织的血管化,而血管生成是生理及病理性组织生长和损伤愈合的基础,故血管内皮细胞生长因子在损伤修复中有重要的作用.目前认为这一作用主要是促进内皮细胞有丝分裂和使细胞通透性增强,通过和血管内皮细胞的特异性受体结合,产生强大的促进内皮增殖及血管生成作用而实现的.     

UV Photodissociation Dynamics of Nitric Acid： The Hydroxyl Elimination Channel

Sliced velocity mapping ion imaging technique was employed to investigate the dynamics of the hydroxyl elimination channel in the photodissociaiton of nitric acid in the ultraviolet region. The OH product was detected by （2＋1） resonance enhanced multiphoton ionization via the D^2∑^- electronic state. The total kinetic energy spectra of the OH＋NO2 channel from the photolysis of HONO2 show that both ：NO2（X2A1） and NO2（A2B2） channels are present, suggesting that both 1^1A″ and 2^1A″ excited electronic states of HONO2 are involved in the excitation. The parallel angular distributions suggest that the dissociation of the nitric acid is a fast process in comparison with the rotational period of the HNO3 molecule. The anisotropy parameter β for the hydroxyl elimination channel is found to be dependent on the OH product rotational state as well as the photolysis energy.     

计算层板成像光谱仪的仿真研究

介绍一种无需时间或空间扫描的新型成像光谱仪－计算层析成像光谱仪（ＣＴＩＳ），并对其基本原理进行了详细叙述和方程式表达。系统的投影矩阵是由理论推导得出，采用广义矩阵的截断奇异值分解法作为计算机层析成像重建算法。为了便于计算机仿真建立了一种简单的数理模型。仿真实验表明该理论、数理模型和算法准确合理，且算法的重建效率高、系统误差小。     

网络安全和日常维护

本文通过综合运用SNMP采样、NetFlow分析和探针分析,并且利用Juniper路由器特有的端口镜像功能将这三种手段有效地结合起来,构造出一种“切片式”监控系统,可以较好地完成粗、细粒度结合的电信网络集中监控任务,从而为保障电信运营商网络安全打下一个坚实的基础。     

中药治疗“全小肠血管畸形”术后再出血一例

小肠血管畸形的治疗以切除病变小肠段为主．本例患者系全小肠血管畸形、已作了最大限度的切除术，而术后仍出血不止，求助于中医治疗．在辩证为“脾虚气弱”后，以补脾益气、温中止血治疗，使术后出血不仅得到控制，而且疗效巩固，迄今已停药两年余，患者身体健康     

抗肿瘤血管形成的研究进展(综述)

肿瘤的发生、发展、转归在很大程度上依赖于血管生成。这个假设最初由Ｆｏｌｋｍａｎ等［１］提出，主要依据是：（１）体外培养的肿瘤体积只能在１～２ｍｍ３，而植入鼠体内体积可迅速扩展到数立方厘米；（２）体外培养的血管内皮细胞分裂有限；（３）体外培养的器官无血管。之后，Ｈａｎａｈａｎ等［２］又提出了“血管形成的开关平衡假说”，即血管形成过程依赖血管生成因子与抑制因子的调节。目前，研究肿瘤治疗的一个新方向是抑制或破坏新生血管的形成，切断肿瘤生长和转移所依赖的“命脉”。这方面的研究主要在以下４个方向进行；（１…     

川金丝猴和人子宫动脉的铸型观察

为了观察金川丝猴子宫血管的构筑情况及其与人子宫血管构筑的异同，探讨子宫内膜脱落和月经产生的形态学机制，用血管铸型技术观察研究了川金丝猴和人的子宫动脉，结果表明人子宫血管丰富密集，川金丝猴子宫血管则较稀疏，两者均可分为中、中、外3个血管层，相邻弓状动脉及其3-4级分支间有大量纵向及横向吻合，虽然两者内膜动脉血管大小有差异，但均呈不同程度的弹簧状或螺旋状内向垂直穿行，其间缺乏吻合。在螺旋动脉直部或螺旋部均有明显的缩窄环。月经期的动物螺旋状向内垂直穿行，其间缺乏吻合。在螺旋动脉直部或螺旋部均有明显的缩窄环。月经期的动物螺旋动脉变粗，呈明显的扩张状。川金丝猴和人子宫内膜动脉血管的形态与无月经的鼠兔、家兔等子宫内膜动脉血管明显差异。内膜动脉血管的特殊形态与月经的周期密切相关。