基于几何不变量的蛋白质三维分子结构比对

为了解决蛋白质三维结构比对需要处理大量的旋转、平移变换，直接用动态规划将变得十分繁琐这一问题，在保留蛋白质空间结构属性特征的基础上，对蛋白质三维数据进行了预先的处理．通过计算蛋白质结构在旋转和平移下的几何不变量，将蛋白质的三维结构坐标变换为具有旋转、平移不变性的一维序列．进一步给出了“距离”以及“相似得分”的定义．在此基础上采用动态规划方法给出了新的蛋白质结构比对算法．对专家分类的蛋白质结构数据库进行测试，结果显示准确、快速．     

Effect of Notoginsenoside-Rg1 on the Expression of Several Proteins in the Striatum of Rat Models with Parkinson＇s Disease

After establishing hemi-Parkinsonian rat models, the relationships between neuron death and the expression of several proteins, such as c-Fos, GFAP, GDNF, NF-κB and some cytokines were determined. Therapeutics experiments with notoginsenoside-Rg1 were carried out. The research results show that the expressions of GFAP, NF-Kκ and c-Fos will obviously increase in the lesion side of the striatum and the expression of GDNF will decrease, which implies that the signal transduction pathway may participate in the apoptosis in neurons. The levels of some cytokines such as TNF-α, IL-1β in the striatum of PD rat models increased compared to those of normal rats. The results of the therapeutics experiments show that notoginsenoside-Rg1 may repress the immune inflammation response and regulate the immune function through the neuro-immune molecular network. Therefore, notoginsenoside-Rg1 can be used as an effective drug for anti-oxidation and anti-inflammation, and can be used in the therapy of Parkinson＇s disease（PD）.     

饲喂频率对鲈鱼生长及体生化成分的影响

选取同一种饵料设置1次·d-1、2次·d-1、3次·d-1、4次·d-14个饲喂频率,采用静水连续充气养殖系统,在盐度为26.0%～27.0%、温度为26～30℃条件下对鲈鱼(85.95±2.04)g进行为期40d的生长实验.结果表明:(1)饲喂频率影响鲈鱼的生长是由食物转化率和摄食率的提高共同引起的.(2)水分含量随饲喂频率的增高而保持不变;蛋白质含量随饲喂频率的增加,基本保持不变;脂肪含量随饲喂频率的增高而明显减少;灰分含量随饲喂频率的增多而明显增加.(3)鲈鱼的适宜饲喂频率为2次·d-1.     

现代优化计算方法在蛋白质结构预测中的应用

现代优化计算方法在蛋白质结构预测中占有重要地位.简要地介绍了模拟退火算法,遗传算法,人工神经网络和图论算法在蛋白质结构预测中的应用.对国内外近年来应用这些算法,特别是在蛋白质构象搜索问题中,解决蛋白质结构预测的研究作了回顾,并分析、比较了这几种算法的效果和特点.     

镍-酸性铬兰K络合物吸附波

用微分脉冲溶出伏安法研究了镍(11)与酸性铬兰K(ACBK)所生成的络合物在悬汞电极上的电化学特性及电化学反应机理，发现电极反应为镍与酸性铬兰K所生成的络合物吸附在电极表面后发生的不可逆还原。在HCl-硼砂介质中(pH8．67)，络合物在-316mV处有一吸附还原峰，其峰电流与镍浓度在0．001～0．010μ/mL范围内呈现良好的线性关系，其最低检出浓度为0．0005μg／mL。     

Nonlinear Correlations of Protein Sequences and Symmetries of Their Structures

We investigate the nonlinear correlations of protein sequences by using the nonlinear prediction method developed in nonlinear dynamical theory. It is found that a lot of protein sequences show strong nonlinear correlations and have deterministic structures. Further investigations show that the strong nonlinear correlations of these protein sequences are due to the symmetries of their tertiary structures. Furthermore, the correlation lengths of the sequences are related to the degrees of the symmetries. These results support the duplication mechanism of protein evolution and also reveal one aspect how amino acid sequences encode their spatial structures.     

酵母蛋白质网络的动力学性质

蛋白质-蛋白质、蛋白质-DNA相互作用网络决定了细胞中各种关键功能的执行．基于芽殖酵母(budding yeast saccharomyces cerevisiae)的蛋白质-蛋白质相互作用网络数据和相关的实验文献，我们建立了调控细胞周期和生命周期(cell cycle and life cycle)的蛋白质网络，并利用离散模型研究了该网络的动力学性质，研究表明：细胞周期网络的动力学性质具有很强的稳定性，约94％的蛋白质初态将演化到对应于生物学G1基态的稳定态，使其成为惟一的全局吸引点；同时，绝大多数的初态的演化路径都通过由G1激发态到G1基态的细胞周期演化路径，使细胞周期路径成为全局性的“吸引”路径。     

Photoluminescence Characterization of Silicon Nanoparticles Hybridized Europium Complex

A europium complex Eu (DBM)3 TPPO (Eu tris(benzoylmethide)-(triphenylphosphine oxide)) and silicon nanoparticles have been hybridized.The hybridization can evidently change the photoluminescence (PL) characteristics of the Eu complex in the following aspects:under an excitation of 390nm,the intensity of the PL peak at 611nm due to the ^5Du-^7F2 transition of the Eu^3 ions has been increased by 30%,and thc integrated PL intensity in the visible range has been increased by nearly 3 times;the PL excitation efficiency beyond 440nm has been improved cvidently;the peak in the PL excitation spectrum shifts from 408nm to 388nm,and the PL decay time decreases from 2.07 to 0.96μs,The experimental results indicatde that in the PL process,the photoexcited energy may transfer from the silicon nanoparticlcs to the Eu^3 ions.     

在三通道α-螺旋蛋白质中传递生物能量的孤子的特性

用庞小峰先生提出的生物能量传递的新理论和 Runge-Kutta数值模拟方法,研究了三通道α-螺旋蛋白质中激发的孤子的动力学特性,求出在0K和300K温度下该孤子稳定地沿蛋白质链传递.由此可见,它能担任在蛋白质分子中传递生物能量的功能.从而再次证实了新理论的可利用性.