循证医学对肿瘤临床实践的指导意义

介绍循证医学产生的背景及其对肿瘤临床的实践意义，肿瘤学循证医学文献检索的几种主要的数据库。     

电话会议系统中电话事件状态及状态转移设计

以一个电话会议汇接系统的设计开发为例，针对电话会议汇接系统的实时性、多任务的特点，运用有限状态机模型，从状态和状态转移的设计入手，结合面向对象程序语言编程，探讨此类系统的软件设计的思路和方法。     

Advances in identification and application of tumor antigen inducing anti-cancer responses

Tumor antigen is one of the important bases of tumor immunotherapy . With the discovery of novel tumor antigens, interest in specific immunotherapy for treatment of malignancies has increased substantially. Nowadays more and more scientists paid close attention to various tumor antigens with their roles or/and applications in anti-cancer immune responses, immune tolerance, tumor markers,     

Classification of Medical Brain Images

Since brain tumors endanger people‘s living quality and even their lives, the accuracy of classification becomes more important. Conventional classifying techniques are used to deal with thosedatasets with characters and numbers. It is difficult, however, to apply them to datasets that include brain images and medical history (alphanumeric data), especially to guarantee the accuracy.For these datasets, this paper combines the knowledge of medical field and improves the traditional decision tree. The new classification algorithm with the direction of the medical knowledge not only adds the interaction with the doctors, but also enhances the quality of classification. The algorithm has been used on real brain CT images and a precious rule has been gained from the experiments. This oaoer shows that the ahzorithm works well for real CT data.     

Recent progress in polymer-based gene delivery vectors

The gene delivery system is one of the three components of a gene medicine, which is the bottle neck of current gene therapy. Nonviral vectors offer advantages over the viral system of safety, ease of manufacturing, etc. As important nonviral vectors, polymer gene delivery systems have gained increasing attention and have begun to show increasing promising. In this review, the fundamental and recent progress of polymer-based gene delivery vectors is reviewed.     

Inhibitory effect of the adenovirus type 5 E1A protein expressed in the yeast system of the human tumor cell growth

Adenovirus 5 type E1A as a tumor suppressor gene can inhibit tumor growth and enhance the censitivity of chemotherapy and radiotherapy.E1A have the ability to integrate into the host genome,resulting in long-time expres-sion that induces Rb gene inactivation and animal cells im-mortalization.This prompted us to select the E1A protein for treatment of cancer in order to overcome the limitations of E1A gene therapy.Thus,we firstly comstructed E1A eu-caryotic expression vector (pPIC9/E1A),transformated the pichia pastoris yeast cells(GS115) and screened the high-expressing recombinant strains.The positive yeast strains were cultured in the shake flask,and induced for 3d.The crude E1A protein was purified using two steps of col-umu chromatography on HiTrap Q and HiTrap SP.The pu-rified E1A protein was identified by SDS-PAGE and Western blot.E1A protein was mostly located at cellular unclear when Cheriot delivered E1A protein into cells.The analysis in vitro indicated that the E1A protein arrested LN686 cell cycle at G2/M phase,and significantly inhibited the growth of LN686 tumor cells.The current studies firstly provided an experimental basis to further develop E1A protein for tumor treatment.     

1,3-苯二氧基二乙酸二芳酯的合成及植物生长调节活性

以PEG 4 0 0为催化剂 ,在液 液相转移催化条件下合成了一系列新的 1,3 苯二氧基二乙酸二芳酯 .用元素分析、IR以及1 HNMR确定了它们的结构 .初步生物活性试验表明 ,该类化合物对小麦幼苗的生长有一定的促进作用 .     

G-凸空间中关于容许集值映象的广义拓扑SKKM定理

在G—凸空间中引入了关于容许集值映象的G—SKKM映象，建立了具紧闭值或转移闭值的关于容许集值映象的G—SKKM映象的广义拓扑SKKM定理，改进和推广了近期的相应结果．     

我国农业剩余劳动力转移的时间分析和对策研究

农业劳动力份额由75％下降到10％，被视为一国基本上完成农业劳动力转移的标志，要做到这一步，根据预测我国大约需要55年的时间。作者在分析农业剩余劳动力转移障碍的基础上，提出了引导农业剩余劳动力合理流动的对策。     

防范跨国公司内部价格转移的对策研究

目前，跨国公司进驻我国已成为客观必然，而且将越来越多。跨国公司在推动我国经济发展的同时，也不可避免地带来了一些负面影响。最主要的方面就是利用其内部贸易，将本该属于我国享有的利润通过价格转移的手段转移到国外的母公司，致使我国的税收减少，既影响了财政收入，也影响了我国正常的经济秩序。这表明，我国防范跨国公司内部价格转移的法律制度还不健全，措施也欠完善。国外尤其是发达国家在防范跨国公司价格转移方面已经颇有成效，因此就防范措施进行国际比较，以期对我国该问题的实践有所启示和借鉴。