色素痣样病变临床及病理分析

目的探讨色素痣样病变的临床特点及其病理学特性,并进行分析,以供参考。方法选取2012年1月~2014年2月该院收治的色素痣样病变患者,共400例作为研究对象。对所有患者的临床病理资料做出统一的整理,并进行分析。结果在400例色素痣样病变的患者中,经过临床手术确诊的色素痣患者有299例(74.75%),其中,以皮内痣、混合痣和交界痣所占的比例为最重,分别为59.75%、10.00%、5.00%。结论在临床诊断中,色素痣样病变的误诊现象发生率较高,只有将患者的临床病理进行详细的组合分析,才能有效提高色素痣样病变的诊断率,防止误诊现象的发生。     

碘油滞留对肝内占位病变的鉴别诊断

对经病理证实的１００例肝内占位病变碘油肝动脉造影资料进行分析，结果显示碘油不仅能积聚在多血管恶性肿病中，也能积聚在多血管良性肿瘤内，其影像无差别，但碘油在病灶内滞留时间则明显不同，在恶性肿瘤内碘油能长时间滞留（１月以上），而良性肿瘤，除血管瘤外，碘油在３周内消散。利用碘油滞留时间不同这一特性，可对肝脏多血管良、恶性肿瘤进行鉴别诊断。     

鞍内罕见病变2例报告

1　一般资料病例 1 .连某 ,女 ,40岁 ,阵发性头疼 ,头晕 2 0ｄ伴月经失调 .无视力障碍 ,无视野缺损 ,无内分泌改变 ,血糖 1 4.3ｍｍｏｌ/Ｌ ,经用胰岛素治疗效果不明显 .内分泌系统检查均正常 .蝶鞍Ｘ线片 :蝶鞍前后径 1 5ｍｍ ,深径 1 5ｍｍ ,后床突上翘 ,并见骨质吸收 ,前床突无改变 .头部ＣＴ :鞍内可见一类圆形稍高密度影 ,边界清晰 ,大小 2 .0ｃｍ× 2 .0ｃｍ ,鞍底呈半圆形下凹 ,增强后无强化 .头部ＭＲＩ:鞍内见直径2 .0ｃｍ长Ｔ1 、长Ｔ2 信号 .术前诊断 :无功能垂体腺瘤 .手术在全麻下经鼻小柱———蝶窦入路 ,打开鞍底 ,见鞍内硬…     

Development of Triticum aestivum-Leymus racemosus ditelosomic substitution line 7Lr#1S（7A） with resistance to wheat scab and its meiotic behavior analysis

Leymus racemosus is highly resistant to wheat scab （Fusarum head bright）. The transfer of scab resistant gene from L. racemosus to Triticum aestivum is of great significance for broadening the base of wheat resistance. In the present study, the pollen of T. aestivum-L, racemosus monosomic addition line with scab resistance was treated by irradiation with 1200 R ^60Co-γ-rays prior to pollinating to emasculated wheat cv. Mianyang 85-45. Nine plants with a telocentric chromosome 7Lr#1S were observed in M1, and one ditelosomic substitution line 7Lr#1S was selected from selfcrossing progenies and confirmed by chromosome C-banding and GISH. Furthermore, a co-dominant EST-SSR marker CINAU 31 was employed to identify this substitution line. A pair of chromosome 7A of common wheat were found to be replaced by a pair of telocentric chromosome 7Lr#1S, and further investigation showed that chromosome configuration of the substitution line at MI of PMCs after GISH was 17.50Ⅱ^w ＋ 2.19Ⅱ^w ＋ 0.42Ⅱ^7Lr#1S ＋ 1.08 Ⅰ^7Lr#1S ＋ 0.69 Ⅰ^w. Two telocentric chromosomes paired as a bivalent in 59.7% of PMCs. Abnormal chromosome behaviors of telocentric chromosomes were observed in part of PMCs at anaphase I and telophase I, including the moving of two telocentric chromosomes to the same pole, lagging and earlier separation of their sister chromatid. All these abnormal behaviors can be grouped into three distinct types of tetrads according to different numbers of 7Lr#1S in their daughter cells and various micronucleus in some tetrads. However, due to the high transmission frequency of the female and male gametes with a 7Lr#1S, 84% of the selfcrossing progeny plants had ditelosomic substitution. The substitution line showed high resistance to wheat scab in a successive two-year test both in the greenhouse and field; hence, the line will be particularly valuable for alien gene mapping, small fragment translocation induction and telosomic cytological behavior analysis.     

Study on microscope hyperspectral medical imaging method for biomedical quantitative analysis

A microscopic pushbroom hyperspectral imaging system was developed based on the microscopic technology and spectral imaging technology according to the principle of spectral imager in remote sensing. The basic principle and key technologies of this system were presented and the system per- formance was also analyzed. Some methods and algorithms were proposed to preprocess and nor- malize the microscopic hyperspectral data and retrieve the transmittance spectrum of samples. As a case study, the microscopic hyperspectral imaging system was used to image the retina sections of different rats and get some significant results. Experiment results show that the system can be used for the quantitative assessment and evaluating the effect of medication in biomedical research.     

连续2D TOF法MRA对椎动脉病变的临床应用价值

目的：采用连续2DTOF法MRA无创成像技术探讨椎动脉病变的MRA表现及其临床应用价值．方法：对350例椎动脉病变病人和50例正常人分别进行磁共振血管成像,并对检查结果进行分析研究．结果：把正常人椎动脉平均分三段测量直径,得到MRA椎动脉正常值,左侧（4．1±0．79）mm,右侧（3．2±0．83）mm．350例椎动脉病变病人中,椎动脉扭曲26例,椎动脉狭窄320例（其中轻度狭窄85例,中度狭窄147例,重度狭窄88例）,椎动脉完全闭塞4例．结论：MRA是椎动脉病变的重要检查方法,对本病的诊断、分型、治疗方法的选择和预后判断具有重要价值．     

视网膜脱离后PVR的形成与氧自由基和锌、铜关系的研究

为探讨氧自由基和锌、铜在视网膜脱离后增殖性玻璃体视网膜病变 (PVR)中的作用 ,收集了 48例视网膜脱离患者视网膜下液 (SRF) ,利用紫外分光光度计测定了SRF中LPO的含量和SOD的活性 ,用原子吸收光谱法测定了Zn、Cu的含量。结果表明 ,随着PVR程度及玻璃体浑浊的加重、病程的延长 ,LPO含量增加 ,SOD活性明显下降 ,P <0 0 5 ,差异有统计学意义。提示SRF中LPO、Zn、Cu含量及SOD活性的改变与视网膜脱离后PVR的发生、发展有密切关系。     

PPAR-γ防治糖尿病视网膜病变的作用机制

糖尿病视网膜病变(Diabetic retinopathy,DR)是糖尿病引起的微血管并发症之一,是致盲的主要原因之一。高糖引起DR的机制包括糖基化终末产物(AGEs)的生成、氧化应激以及炎症反应等。目前DR的发病机制尚未明确,治疗DR仍然面临严峻的挑战。最近研究显示,过氧化物酶体增殖物激活受体-γ(PPAR-γ)及其激动剂噻唑烷二酮类药物(TZDs)具有增强胰岛素敏感性、拮抗AGEs生成、抗氧化、抗炎以及抗血管生成等作用,可能成为治疗由高糖引起视网膜损害的一种新方法。该文就PPAR-γ防治DR的作用机制进行综述。