Finding finer functions for partially characterized proteins by protein-protein interaction networks

Based on high-throughput data, numerous algorithms have been designed to find functions of novel proteins. However, the effectiveness of such algorithms is currently limited by some fundamental factors, including (1) the low a-priori probability of novel proteins participating in a detailed function; (2) the huge false data present in high-throughput datasets; (3) the incomplete data coverage of functional classes; (4) the abundant but heterogeneous negative samples for training the algorithms; and (5) the lack of detailed functional knowledge for training algorithms. Here, for partially characterized proteins, we suggest an approach to finding their finer functions based on protein interaction sub-networks or gene expression patterns, defined in function-specific subspaces. The proposed approach can lessen the above-mentioned problems by properly defining the prediction range and functionally filtering the noisy data, and thus can efficiently find proteins’ novel functions. For thousands of yeast and human proteins partially characterized, it is able to reliably find their finer functions (e.g., the translational functions) with more than 90% precision. The predicted finer functions are highly valuable both for guiding the follow-up wet-lab validation and for providing the necessary data for training algorithms to learn other proteins.     

国外高校图书馆个性化信息服务探析

简要地论述了国外图书馆个性化信息服务的发展状况和典型案例,分析了其特点,探索了其思路,探寻了其个性化信息服务的组织与管理方法。     

具有控制系数的高阶线性微分方程复振荡的一个结果

该文考虑具有控制系数 A\-0 和系数仅有有限个极点的高阶线性齐次微分方程（1.1）。得到了一个复振荡结果，该结果是J. K. Langley［11］等作者在整系数下相应结果的推广。     

信息快递

中国科学家实现DNA分子手术一“笔”挥就；我国每年实际直接利用地热资源居世界第一位；我国科教投入大幅增长 科技人员数量居世界第一。     

浅谈网络环境下高校图书馆信息资源建设

阐述了网络环境下高校图书馆信息资源建设存在的主要问题,探讨了网络环境对信息资源建设的影响,提出了信息资源建设的具体措施。     

Lüroth误差和函数的若干性质

本文研究了Lüroth展式的误差和函数.利用误差和函数的Perron-Frobenius算子,得到其积分值.最后,考察并获得其介值性定理,从而得出其图形是一个分形.     

关于高校信息化建设问题的探讨

阐述了高校信息化建设的必要性,分析了高校信息化建设的现状及存在的问题,提出了解决问题的几点建议。     

数学串诗一首

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