3-{1-苯基-5-[N,N-二(2′-氯乙基)-氨基]-苯并咪唑-2-基}-丙酸

以2,4-二硝基氯苯和苯胺为起始原料,经取代、还原、酰化、环合、水解和成盐等八步反应合成目标化合3-{1-苯基-5-[N,N-二(2′-氯乙基)-氨基]-苯并咪唑-2-基}-丙酸,产物及重要中间体的结构均经1H NMR、IR得到确证。     

水相回流条件下N-取代吖啶二酮衍生物的合成

在水相回流条件下,以芳香醛、5,5-二甲基-1,3-环己二酮（达米酮）和苯胺/对甲苯胺为原料,经过多组分一锅反应,合成了一系列N-取代吖啶二酮衍生物,收率在69%~90%之间。 该过程以水作为溶剂,无有机溶剂污染,而且操作简单,后处理方便。     

Synthesis and Primary Research on Antitumor Activity of Three New Panaxadiol Fatty Acid Esters

For making use of Ginseng resources that exhibit an antitumor activity and for finding new anticancer drugs,three new fatty acid ester compounds: 3β-acetoxy panaxadiol ( Ⅰ ), 3β-palmitic acid aceloxy panaxadiol ( Ⅱ ), and 3β-octadecanoic acid aceloxy panaxadiol( Ⅰ , Ⅱ , and Ⅲ ) were synthesized with panaxadiol, diacetyl oxide, palmityl chloride and stearyl chloride, and their structures were determined via MS, 13C NMR, IR, TLC, and so on. The molar yields of the three compounds are 75.14%, 79. 08%, and 72. 57%, respectively. Meanwhile, the antitumor activity of the three new panaxadiol fatty acid ester derivatives and panaxadiol was compared by using the method of MTT. Tumor cell used was Vero cell line. Positive control was 5-FU, blank was an RPMI1640 culture medium, negative control was an RPMI1640 culture medium and the solvent for drugs to be tested. Compound Ⅰ has the strongest antitumor activity followed by panaxadiol; compounds Ⅱ and Ⅲ have similar and weakest antitumor activities.Furthermore, the antitumor activities of the panaxadiol fatty acid ester derivatives show positive correlation with the concentration of the test group, but show no relationship with the molecular weight of fatty acid. The methods that are used to synthesize the three compounds with high yields and strong antitumor activities are simple and show a great potential for meeting the needs of industrial manufacture of these drugs.     

俗名易传承──吴中路名、园名、塔名杂谈

吴中的路名、园名、塔名多有雅名与俗名之别，俗名通俗、简明、易称、易记，贴近生活，因此就易传承。本文从语音学、民俗学的角度，对苏州部分街巷、园林、古塔之名由俗代雅的现象作了考证。     

用GAL构成无计数误差的倍频鉴相器

从逻辑和时序上说明了无计数误差四倍频鉴相器的结构，为使此结构满足GAL的“组合逻辑结构”，给出了满足GAL的逻辑方程。     

不可线性化的回归模型的参数估计方法与应用

讨论求解不可线性化的回归模型的参数估计方法－雅可比矩阵递推法，并把它应用于烟蚜危害研究中，同时还将它与常规做法作了比较。结果表明，用该方法所得的有关参数明显优于常规做法，特别是可大大降低残差平方和（最大下降率可达６４．８％）。     

翻译的“达意”与“得意”

将索绪尔的语言学理论、现代信息论思想与我国古人老子、王弼关于“象”、“言”、“意”关系之论述相结合，提出了“达意”与“得意”的概念。“达意”是就非原母语译的释而言的，其前提是译对原评议的理解；翻译的最终目的不是将原翻译，而是要让译的读领会原作所传达的信息，即“得意”。所以“达意”是对译的要求，而“得意”则是对译读的要求。