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1.
Solid‐state 31P NMR investigation on the status of guanine nucleotides in paclitaxel‐stabilized microtubules
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Ga Hyang Lee Su Young Oh Kwon Joo Yeo Taslima Ferdous Meeyeon Cho Younkee Paik 《Magnetic resonance in chemistry : MRC》2015,53(5):330-336
Microtubule dynamics is a target for many chemotherapeutic drugs. In order to understand the biochemical effects of paclitaxel on the GTPase activity of tubulin, the status of guanine nucleotides in microtubules was investigated by 31P cross‐polarization magic angle spinning (CPMAS) NMR. Microtubules were freshly prepared in vitro in the presence of paclitaxel and then lyophilized in sucrose buffer for solid‐state NMR experiments. A 31P CPMAS NMR spectrum with the SNR of 25 was successfully acquired from the lyophilized microtubule sample. The broadness of the 31P spectral lines in the spectrum indicates that the molecular environments around the guanine nucleotides inside tubulin may not be as crystalline as reported by many diffraction studies. Deconvolution of the spectrum into four spectral components was carried out in comparison with the 31P NMR spectra obtained from five control samples. The spectral analysis suggested that about 13% of the nucleotides were present as GTP and 37% as GDP in the β‐tubulin (E‐site) of the microtubules. It was found that most of the GDPs were present as GDP‐Pi complex in the microtubules, which seems to be one of the effects of paclitaxel binding. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
2.
Chuanming Zong 《Monatshefte für Mathematik》2002,134(3):247-255
In this article we study the simultaneous packing and covering constants of two-dimensional centrally symmetric convex domains.
Besides an identity result between translative case and lattice case and a general upper bound, exact values for some special
domains are determined. Similar to Mahler and Reinhardt’s result about packing densities, we show that the simultaneous packing
and covering constant of an octagon is larger than that of a circle.
(Received 17 January 2001; in revised form 13 July 2001) 相似文献
3.
Marco Biroli Silvia Mataloni Michele Matzeu 《NoDEA : Nonlinear Differential Equations and Applications》2005,12(3):295-321
Some stability results for Mountain Pass and Linking type solutions of semilinear problems involving a very general class
of Dirichlet forms are stated. The non linear terms are supposed to have a suitable superlinear growth and the family of Dirichlet
forms is required to be dominated from below and from above by a fixed diffusion type form. Some concrete examples are also
given. 相似文献
4.
Dorina Mitrea Marius Mitrea Jill Pipher 《Journal of Fourier Analysis and Applications》1997,3(2):131-192
We study boundary value problems for the time-harmonic form of the Maxwell equations, as well as for other related systems
of equations, on arbitrary Lipschitz domains in the three-dimensional Euclidean space. The main goal is to develop the corresponding
theory for Lp-integrable bounday data for optimal values of p's. We also discuss a number of relevant applications in electromagnetic scattering. 相似文献
5.
Eremenko L. T. Oreshko G. V. Nesterenko D. A. Lagodzinskaya G. V. Eremenko I. L. 《Russian Chemical Bulletin》2002,51(1):157-159
The reactions of ethylene glycol mononitrate and glycerol 1,3-dinitrate with methylphosphonic dichloride afforded new nitroxyalkyl methylphosphonates. 相似文献
6.
Reinhard Farwig 《Acta Appl Math》1994,37(1-2):41-51
In this note, we discuss the reflection principle of the Stokes system in a half space for the threedimensional case, and of the biharmonic equation. Admitting different boundary conditions, we use the reflection principle to prove uniqueness of solutions of the Stokes system or the biharmonic equation in weightedLq-spaces 相似文献
7.
Let E\subset \Bbb R
s
be compact and let d
n
E
denote the dimension of the space of polynomials of degree at most n in s variables restricted to E . We introduce the notion of an asymptotic interpolation measure (AIM). Such a measure, if it exists , describes the asymptotic behavior of any scheme τ
n
={ \bf x
k,n
}
k=1
dnE
, n=1,2,\ldots , of nodes for multivariate polynomial interpolation for which the norms of the corresponding interpolation operators do
not grow geometrically large with n . We demonstrate the existence of AIMs for the finite union of compact subsets of certain algebraic curves in R
2
. It turns out that the theory of logarithmic potentials with external fields plays a useful role in the investigation. Furthermore,
for the sets mentioned above, we give a computationally simple construction for ``good' interpolation schemes.
November 9, 2000. Date revised: August 4, 2001. Date accepted: September 14, 2001. 相似文献
8.
New Spiro Compounds from Cyclophosphazenes and Cyclodi[phosphadiazanes] Chlorocyclophosphazenes (Cl2P = N)3 and (Cl2p = N)4 react with dihydrazidophosphoric acid derivatives in THF in the presence of triethylamine to give the spirocyclic compounds Cl4N3P3(NHN(CH3))2P(S)OC6H5, Cl6N4P4(NHNH)2P(S)OC6H5. Constitutions have been confirmed by MS, NMR, IR and elemental analysis. 相似文献
9.
Stephen J. Gardiner 《Advances in Mathematics》2007,214(1):417-436
This paper answers a question of Fuglede about minimal positive harmonic functions associated with irregular boundary points. As a consequence, an old and central problem of fine potential theory, concerning the Riesz decomposition, is resolved. Namely, it is shown that, on certain fine domains, there exist positive finely superharmonic functions which do not admit any positive finely harmonic minorant and yet are not fine potentials. 相似文献
10.
We give general conditions on a generator of a C0-semigroup (resp. of a C0-resolvent) on Lp(E,μ), p ≥ 1, where E is an arbitrary (Lusin) topological space and μ a σ-finite measure on its Borel σ-algebra, so that it generates a sufficiently
regular Markov process on E. We present a general method how these conditions can be checked in many situations. Applications to solve stochastic differential
equations on Hilbert space in the sense of a martingale problem are given.
Dedicated to Giuseppe Da Prato on the occasion of his 70th birthday 相似文献