基于LabVIEW的车灯日行灯自动化测试

设计了一种汽车日行灯自动测试系统。该系统主要由工业计算机、高性能数字摄像机硬件平台和LabVIEW软件平台两部分构成。采用摄像机拍摄一张标准日行灯图片作为模板,对待测试的日行灯进行图像采集且与模板比较。由模板定位出测试窗口,然后对各个窗口进行RGB模型分析和HSL模型分析,从而完成对日行灯颜色和明度的检测。此外,系统可同时对多个窗口进行分析,并可实时显示测试画面和测试结果,一次测试时间不超过6 s,且准确度和重复性较好,已在实际中应用。     

传统运营商与虚拟运营商合作模式选择及系统实现方案研究

根据工业和信息化部《关于开展移动通信转售业务试点工作的通告》,电信业下一步的工作重点是发展电信转售业务,运营商可以利用虚拟运营商营销手段多样化的优势,将话音、流量套餐进行批发,再经虚拟运营商与自营商品及服务进行捆绑销售,从而有效拓展传统运营商市场销售渠道。针对电信运营商与虚拟运营商的合作模式、业务发展模式进行比较,提出优化合作建议,并给出可行的组网方案。     

虚拟实时服务:构架、算法及演进路径

提出了一种基于虚拟实时服务的协议构架,可有效发掘用户提出通信请求之前的“负时间轴”上的空闲时频资源或可再生能源,将用户可能感兴趣的内容以多播的方式预先推送到终端的存储器中,从而以非实时的通信提供虚拟实时服务,在确保服务质量的前提下大幅度提升频谱和能量效率.对终端缓存内容的选择算法进行了标准化,从而允许基站在本地预测用户已缓存的内容,并判断当前是否应发起推送和推送哪条内容;提出了虚拟实时服务涉及的若干关键算法,也给出了虚拟实时服务的演进途径及主要开放问题,旨在为相关新兴产业的技术发展提供参考.     

国内外移动虚拟运营商业务模式与经验探讨

首先介绍了移动虚拟运营商的业务特点,然后阐述了虚拟运营商的几种业务模式和基础运营商合作策略以及基于特定业务模式下的虚拟运营商网络架构和特点,最后结合国内电信业现状和国外成功的虚拟运营商案例,为国内虚拟运营商的业务发展归纳出若干经验并提出相关建议。     

Petra,Osiris, and Molinspiration Together as a Guide in Drug Design: Predictions and Correlation Structure/Antibacterial Activity Relationships of New N-Sulfonyl Monocyclic β-Lactams

We report in this article the design and calculated molecular properties of 18 new mono-cyclic β-lactams 4–21, on the basis of one hypothetical antibacterial pharmacophore structure designed to interact with both of Gram-positive bacteria and Gram-negative bacteria. The in vitro biological evaluation of these compounds allowed us to point out new potential non-nucleoside hits, with MIC values in the range of 2–8 μg/mL active against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa. A correlation structure/antibacterial activities relationship of these monocyclic β-lactams is described.

Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.     

Identification of potential HIV-1 integrase strand transfer inhibitors: In silico virtual screening and QM/MM docking studies

HIV-1 integrase (IN) is a retroviral enzyme that catalyses integration of the reverse-transcribed viral DNA into the host genome, which is necessary for efficient viral replication. In this study, we have performed an in silico virtual screening for the identification of potential HIV-1 IN strand transfer (ST) inhibitors. Pharmacophore modelling and atom-based 3D-QSAR studies were carried out for a series of compounds belonging to 3-Hydroxypyrimidine-2,4-diones. Based on the ligand-based pharmacophore model, we obtained a five-point pharmacophore with two hydrogen bond acceptors (A), one hydrogen bond donor (D), one hydrophobic group (H) and one aromatic ring (R) as pharmacophoric features. The pharmacophore hypothesis AADHR was used as a 3D query in a sequential virtual screening study to filter small molecule databases Maybridge, ChemBridge and Asinex. Hits matching with pharmacophore hypothesis AADHR were retrieved and passed progressively through Lipinski’s rule of five filtering, molecular docking and hierarchical clustering. The five compounds with best hits with novel and diverse chemotypes were subjected to QM/MM docking, which showed improved docking accuracy. We further performed molecular dynamics simulation and found three compounds that form stable interactions with key residues. These compounds could be used as a leads for further drug development and rational design of HIV-1 IN inhibitors.     

Theory of docking scores and its application to a customizable scoring function

In general, the docking scoring tends to have a size dependence related to the ranking of compounds. In this paper, we describe a novel method of parameter optimization for docking scores which reduce the size dependence and can efficiently discriminate active compounds from chemical databases. This method is based on a simplified theoretical model of docking scores which enables us to utilize large amounts of data of known active and inactive compounds for a particular target without requiring large computational resources or a complicated procedure. This method is useful for making scoring functions for the identification of novel scaffolds using the knowledge of active compounds for a particular target or a customized scoring function for an interesting family of drug targets.     

Pharmacophore modelling,molecular docking and virtual screening for EGFR (HER 1) tyrosine kinase inhibitors

A pharmacophore model has been developed using diverse classes of epidermal growth factor receptor (EGFR) tyrosine kinase (TK) inhibitors useful in the treatment of human tumours. Among the top 10 generated hypotheses, the second hypothesis, with one hydrogen bond acceptor, one ring aromatic and three hydrophobic features, was found to be the best on the basis of Cat Scramble validation as well as test set prediction (r _training?=?0.89, r _test?=?0.82). The model also maps well to the external test set molecules as well as clinically active molecules and corroborates the docking studies. Finally, 10 hits were identified as potential leads after virtual screening of ZINC database for EGFR TK inhibition. The study may facilitate the designing and discovery of novel EGFR TK inhibitors.     

Virtual isotropic‐nematic transitions in alkyl cyanobiphenyls

Pretransitional fluctuations in the isotropic phase of liquid crystalline and non‐liquid crystalline alkyl cyanobiphenyls have been investigated using light scattering and magnetic birefringence measurements. We find evidence for a virtual isotropic‐nematic phase transition in short‐chain alkyl cyanobiphenyls with no observable nematic phase. The measured temperature dependence of fluctuations is well‐described by mean‐field theory. Virtual phase transition temperatures extrapolated from separate light scattering and magnetic birefringence experiments are in good agreement. Landau–de Gennes model parameters for the compounds investigated are calculated from the experimental results.     

基于SEDRIS的虚拟试验合成环境建模技术研究

为解决合成环境的统一描述和可交互问题,在分析合成环境数据表示与转换标准SEDRIS基础上,提出了基于SEDRIS的虚拟试验合成环境建模方法,针对大气、红外、电磁等3类自然环境,给出了实现环境数据表示和转换的技术途径。通过系统开发,实现了4种试验环境条件下对产品性能的验证与评估,建立的环境模型具有良好的交互性,建模方法可应用于多种试验环境的描述,为虚拟试验合成环境模型体系、标准规范和辅助工具的形成打下了基础。