Comparison of the sensitivity of 11 crosslinked hyaluronic acid gels to bovine testis hyaluronidase

Crosslinked hyaluronan gels are used in various applications where their stability is a prerequisite. The sensitivity of such gels to hyaluronidase can be determined as an index of stability by several approaches: chromatography, electrophoresis, and viscometry. We describe here a test based on the colorimetric determination of the N-acetyl-d-glucosamine released by hyaluronidase in standardized conditions. The sensitivities to bovine testicular hyaluronidase of 11 different gels used to fill skin wrinkles (Restylane; Perlane; Juvéderm 18, 24, 24HV, 30, and 30HV; Surgiderm 18, 24XP, 30, and 30XP) were compared.The method was reproducible, easy to perform, not time-consuming and allowed us to demonstrate that the sensitivity to testicular hyaluronidase was dependent on the degree of crosslinking of the gels and also on their monophasic/biphasic nature. Under our conditions, Surgiderm 30, 24XP and 30XP were the most resistant gels.We propose to retain the hyaluronidase test to predict the in situ stability of a crosslinked gel used to fill skin wrinkles.     

电子碰撞诱导原子从低激态向高激态弛豫

本文根据空心阴极放电中电子能量分布的物理图象,分析了原子从低激态向高激态弛豫的可能途径。建立高低激态集居数密度增量的关系。讨论高激态集居数密度增量获得可观量的条件。根据此条件分别选取钠原子的基态3s~2S_(1/2)和铜原子的亚稳态4s~2D_(3/2)为与激光共振的下能级,并激发具有较大自发发射几率的3s~2S_(1/2)→3p~2P°_(1/2)(和3p~2P°_(3/2))和4s~2D_(3/2)→4p~2P°_(1/2)跃迁,在远离上能级的高激态上观测到敏化荧光,并精确测得这些态的自发发射系数比值,而在更高激态上没有观测到敏化荧光,表明讨论中提出的条件是合理的。     

10W QCW operation of a proton implanted GaAlAs diode laser array

We report one thick layer of hard-baked photoresist mask.The laser array stripe pattern was defined by standard wet lithography.With this mask, a 10 W QCW(quasi-continuous wave) operation of a narrow proton implanted multiple stripe conventional single quantum well separate confinement heterostructure(SQW-SCH) GaAlAs diode laser array has been realized.These devices exhibit the lateral far-field radiation pattern of a phase-locked array of gain-guided semiconductor injection laser array. The twenty stripe laser array has a lateral far-field beam divergence full width at half maximum (FWHM) of less than 3°, and three twenty stripe laser array has a beam divergence in the plane of the junction of about 9°.     

The response of microstructure to processing in a series of poly(siloxaneimide) copolymers

Poly(siloxaneimide) (PSI) segmented copolymers exhibit organized microdomains if the blocks are sufficiently incompatible. As with neat diblock and triblock copolymers, the processing route employed to prepare films of PSI materials is expected to influence the dimensions and/or morphology of the resultant microstructure. In this work, small-angle neutron scattering (SANS) is utilized to characterize the disordered microstructure found in films of a series of PSI copolymers which are subjected to solvent casting and various thermal treatments. Microstructural dimensions such as the periodicity and correlation length are deduced from the Teubner-Strey (TS) model for disordered microemulsions. The scattering intensity of each copolymer up to q = 5.0 nm^?1, where q is the scattering vector, is found to scale as q^?2.8+?0.1. Results indicate that processing the materials as cast films or as melt-pressed films allowed to cool slowly has a small, but discernible, effect on microstructural characteristics. SANS profiles of films quenched from elevated temperatures reveal a clear transition in microdomain periodicity, which correlates well with the glass transition temperature of the imide microphase in these and other materials of similar chemical structure. © 1993 John Wiley & Sons, Inc.     

Continuity properties of the normal cone to the level sets of a quasiconvex function

Two main properties of the subgradient mapping of convex functions are transposed for quasiconvex ones. The continuity of the functionxf(x)^–1f(x) on the domain where it is defined is deduced from some continuity properties of the normal coneN to the level sets of the quasiconvex functionf. We also prove that, under a pseudoconvexity-type condition, the normal coneN(x) to the set {x:f(x)f(x)} can be expressed as the convex hull of the limits of type {N(x _n)}, where {x _n} is a sequence converging tox and contained in a dense subsetD. In particular, whenf is pseudoconvex,D can be taken equal to the set of points wheref is differentiable.This research was completed while the second author was on a sabbatical leave at the University of Montreal and was supported by a NSERC grant. It has its origin in the doctoral thesis of the first author (Ref. 1), prepared under the direction of the second author.The authors are grateful to an anonymous referee and C. Zalinescu for their helpful remarks on a previous version of this paper.     

在H－ZSM－5沸石上甲醇转化为汽油的初始产物分布

在Ｈ－ＺＳＭ－５沸石上甲醇转化为汽油的初始产物分布姜玄珍（浙江大学化学系，杭州３１００２７）Ｒ．Ｆ．Ｈｏｗｅ（新南威尔士大学物理化学系，澳大利亚）关键词Ｈ－ＺＳＭ－５沸石，甲醇转化汽油，产物分布以氢型ＺＳＭ－５沸石作催化剂转化甲醇为汽油（ＭＴＧ），在...     

检测实验室如何开展管理评审工作

详细论述了管理评审的基本概念、如何开展管理评审工作以及中国实验室国家认可委员会的有关政策。     

Spectral studies of bridged bisindenylmetallocenes and products of their reactions with polymethylalumoxane in toluene and dichloromethane in the visible region

Quantitative characteristics of changes in the energy of charge transfer from -bonded ligands to metal are presented for the series of structurally similar ansa-metallocene complexes of IVB Group elements. The changes are caused by the solvation effect, replacement of -bonded chlorine ligands by methyl groups and of bridging ethylene groups by dimethylsilylene moieties, introduction of the methyl substituent into position 2 and phenyl substituent into position 4 of the indenyl system, variation of the transition metal in metallocene, and formation of complexes with polymethylalumoxane (MAO) at different Al_MAO/Zr ratios. These effects are found to be additive.     

Dehydrochlorination of monodisperse poly(vinylidene chloride) latex

The objective of the work described in this paper was to produce dispersions of small spherical carbon particles, having particle diameters in the region of 0.1 μm. To this end, the dehydrochlorination of poly(vinylidene chloride) (PVDC) latex particles was attempted. The PVDC latex was prepared by a dispersion polymerization route. Both chemical and thermal dehydrochlorination routes were attempted. Chemical dehydrochlorination, using a variety of base/solvent systems, led to nonporous, spherical black particles of the required size, but which contained only 60% carbon; most of the remainder was oxygen, introduced by nucleophilic substitution reactions. Thermal dehydrochlorination, at 700°C under a nitrogen atmosphere, using a fluidized bed arrangement, on the other hand, led to black particles, having 90% carbon and which retained their sphericity, but which were highly porous. Initial chemical dehydrochlorination, prior to thermal treatment, did not seem to reduce the porosity of the final carbons. Dispersions of the carbon particles in a variety of solvents were readily achieved.     

A supported gold catalyst for the elimination of hydrogen from CO2 feed gas in the production of urea

Supported gold catalyst for eliminating hydrogen from CO₂ feed gas in the production of urea is found to be superior to other industrial catalysts (e.g. Pt/Al₂O₃ and PdPt/Al₂O₃) in catalytic activity and resistance to sulfur poisoning.