星载海洋监视雷达系统

文中在比较星载海洋监视设备特点的基础上,指出了雷达用于海洋监视的独特优势,并对假设的星载海洋监视雷达系统的工作波段、工作模式、威力覆盖、检测能力进行了具体讨论,分析了星载海洋监视雷达的关键技术。最后指出随着技术的发展,雷达必将成为下一代星载海洋监视的首选设备。     

Impact of wide-band I/Q modulation errors in SAR imaging analysis and compensation method resaerch

Direct quadrature modulation technology is suitable for wide-band radar signal generation. However, this method has rigorous requirements on amplitude and phase balance of the orthogonal input signals. If the requirements are not satisfied, there would be modulation errors such as image frequency and oscillator leakage that cannot be filtered. The modulation errors will therefore raise the noise floor of the range profile and reduce the dynamic range of the Synthetic Aperture Radar (SAR) image as a whole. In this paper, the wide-band In-phase/Quadrature-phase (I/Q) modulation errors are modeling analyzed, and the influence of wide-band I/Q modulation errors on SAR imaging is discussed. Furthermore, a compensation method of modulation errors is proposed, and the circuit implementation of the radar signal generation and pre-distortion is presented. The experimental results illustrate that the curves of the I/Q amplitude and phase imbalance errors are successfully extracted and the rejection of image frequency improved significantly, thus meets the requirements of the SAR imaging.     

基于局部最优匹配的斜视SAR子孔径成像算法

斜视合成孔径雷达(Synthetic Aperture Radar, SAR)能够对雷达平台的侧前或侧后方区域进行观测,极大地增加了雷达的探测范围和灵活性。针对斜视SAR子孔径成像,该文提出一种基于局部最优匹配准则的成像算法。该算法在针对某方位频率构造对应的距离徙动校正、2次距离压缩以及方位补偿函数时,以位于该方位频率处的点目标得到最佳匹配为准则,不同于传统方法的以方位中心点获得最佳匹配为准则,从而能够避免距离方位中心较远的目标的失配,有效地改善了方位边缘区域的聚焦效果。文中通过点目标仿真验证了该算法的有效性。     

男性生殖器在915和2450MHz微波作用下的比吸收率分布

应用模型实验和数字化红外热象技术,定量地测定了男性生殖器在915和2450MHz微波远场和近场作用下的SAR分布。实验表明:男性生殖器对915和2450MHz微波的吸收有极化效应。当微波电场矢量E与阴茎平行时,阴茎吸收最强,最大SAR出现在阴茎基部;当微波电场矢量E与阴茎垂直时,对915MHz微波,最大SAR出现在阴囊中心,对2450MHz微波,最失SAR出现在睾丸内,显示同一器官对不同频率,不同极化微波的吸收特性间的差别。本文对实验结果进行了讨论并与过去的理论分析和实验结果作了比较,显示相当接近。     

Comparison of criteria used to access carcinogenicity in CPANN QSAR models versus the knowledge-based expert system Toxtree

The primary goal of this study was to describe and compare the criteria used to assess carcinogenic activity. The statistically-based predictive quantitative structure–activity relationship (QSAR) models based on the counter propagation artificial neural network (CPANN) algorithm, and knowledge-based expert systems based on a decision tree structural alert (SA) approach (Toxtree application), were considered. The integration of the QSAR (CPANN models) and SAR (Toxtree SA application) approach contributed to the mechanistic understanding of the QSAR model considered. The mapping technique inherent to CPANN Kohonen enables us to relate the similarities or dissimilarities within a congeneric set of chemicals with particular SAs for carcinogenicity. The focus of our investigations was the similarities and dissimilarities of the features used in the QSAR and SAR methods. Due to the complexity of the carcinogenic endpoint, the integration of different approaches allows the models to be improved and provides a valuable technique for evaluating the safety of chemicals.     

Structural study of pyrimidine nucleoside analogues. I: Molecular mechanics and semiempirical calculations of 2′-deoxy-2′-fluoroarabinofuranosyluracils

Molecular mechanics (MM) calculations have been performed on the title compounds. For the MM minimum energy conformation obtained by conformational analysis, molecular orbital (MO) calculations (MNDO and AM1) have also been performed. The geometries obtained have been compared with the experimental ones extracted from the Cambridge Structural Database (CSD). A qualitative structure-activity relationship has been pointed out based on the electrostatic potentials calculated at different positions on the electronic surface.     

Structural identification of SAR-943 metabolites generated by human liver microsomes in vitro using mass spectrometry in combination with analysis of fragmentation patterns

SAR-943 (32-deoxo rapamycin) is a proliferation signal inhibitor via interaction with the mammalian target of rapamycin (mTOR). Most importantly, SAR-943 has improved chemical stability compared to rapamycin (sirolimus) and is currently under investigation as a drug coated on coronary stents. It was the goal of this study to identify the SAR-943 metabolites generated after incubation with human liver microsomes using high-resolution mass spectrometry (MS) and MS/iontrap (MS(n)) and comparison of fragmentation patterns of the metabolites with those of SAR-943 and other known rapamycin derivatives. Our study showed that SAR-943 is mainly hydroxylated and/or demethylated by human liver microsomes. The structures of the following metabolites were identified: O-demethylated metabolites: 39-O-desmethyl, 16-O-desmethyl and 27-O-desmethyl SAR-943; hydroxylated metabolites: hydroxy piperidine SAR-943, 11-hydroxy, 12-hydroxy, 14-hydroxy, 23-hydroxy, 24-hydroxy, 25-hydroxy, 46-hydroxy and 49-hydroxy SAR-943; didemethylated metabolites: 16,39-O-didesmethyl and 27,39-O-didesmethyl SAR-943; demethylated-hydroxylated metabolites: 39-O-desmethyl, 23- or 24-hydroxy and 39-O-desmethyl, hydroxy piperidine SAR-943 and dihydroxylated metabolites: 12-,23- or 24-dihydroxy SAR-943. In addition, several other demethylated-hydroxylated and dihydroxylated metabolites were detected. However, their exact structures could not be identified.     

The new ether derivative of phenylpropanoid and bioactivity was investigated from the leaves of Piper betle L.

Abstract

A new ether derivative of phenylpropanoid compound, γ-(γ′-isohydroxychavicol)-chavicol octanyl ether (K1) along with one known phenylpropanoid named allyl-pyrocatechol or hydroxychavicol (2) were isolated from Piper betle var. kali collected from Tumluk district, West Bengal India. We first report the presence of compound K1 in the genus Piper. Their structures were established on the basis of various spectroscopic analyses. Compounds K1 and 2 showed excellent antioxidant DPPH free radical scavenging activity with IC₅₀ values of 4.61 and 4.12?µg/mL compared to ascorbic acid as a standard antioxidant drug with IC₅₀ value of 3.42?µg/mL, respectively. Evaluation of in vitro cytotoxic activities of compounds K1 and 2 showed significant effects against human oral cancer cell lines (AW13516 and AW8507), human hepatoma cell lines (HEPG2 and PLC-PRF-5) and a human pancreatic cell line (MIA-PA-CA-2), compared to Doxorubicin^® as a standard cytotoxic drug with GI₅₀ values of <10 and 18.18?µg/mL.