Labile Base-Stabilized Silyliumylidene Ions. Non-Metallic Species Capable of Activating Multiple Small Molecules

Several base-stabilized silyliumylidene ions ( 2 and 3 ) with different ligands were synthesized. Their behaviour appeared strongly dependent on the nature of ligand. Indeed, in contrast to the poorly reactive silyliumylidene ions 3 c,d stabilized by strongly donating ligands (DMAP, NHC), the silylene- and sulfide-supported one ( 2-H and 3 a ) exhibits higher reactivity toward various small molecules. Furthermore, their capability to successively activate multiple small molecules was clearly demonstrated by processes involving successive reactions with silane/formamide, CO₂ and H₂. Moreover, HBPin adduct of 3 a ( 8-C ) catalyzes the hydroboration of pyridine. Of particular interest, silylene-supported silyliumylidene complex 2-H is one of the rare species able to activate two H₂ molecules.     

Histone deacetylase (HDAC) inhibitor curcumin upregulates mitochondrial uncoupling protein1 (UCP1) and mitochondrial function in brown adipocytes,in-silico study and screening natural drug library

Mitochondrial dysfunction has been associated with diverse pathological conditions globally. Specifically, in adipose tissues, mitochondrial dysfunction is the primary cause of obesity and obesity-related illnesses. An existing drugs such as atorvastatin and other lipid-lowering drugs demonstrated adverse effects and initiated other diseases. Thus, we need to explore new methods to prevent and treat obesity. In this study, we used the cell screening method to identify several natural compounds that increase adipocyte UCP1 gene expression. The identified drug Curcumin was evaluated in cell models and the In-silico model. We found curcumin is an active compound of turmeric belonging to Zingiberaceae (ginger family), which activates the Nrf2 mechanism. Curcumin potentially endorses the expression of UCP1 in the brown adipocyte in vitro cellular model. Curcumin plays an important role that modulating mitochondrial function and improving mitochondrial DNA quantification, ATP production, and cell viability. We have established an efficient in vitro cell experiment system to study the metabolic regulation of UCP1. The in-silico model revealed curcumin-UCP1 interaction. Curcumin, via enhancing mitochondrial activity, could be a helpful therapeutic molecule against metabolic disorders or obesity-related diseases. Curcumin will be the subject of more research in both human and murine models, which will provide novel therapeutic pathways for the treatment of metabolic illnesses by modulating the control of mitochondrial function.     

磁共振扩散加权成像联合血清AFP对小肝癌临床诊断及疗效评估的价值

将194例小肝癌患者纳入小肝癌组,185例肝细胞结节患者纳入结节组,所有患者均行MRI扩散加权成像(DWI-MRI),评估患者在DWI-MRI上的形态学表现及ADC值,检测患者血清AFP水平,比较不同检测方法诊断小肝癌的准确度、灵敏度、特异度。结果显示,应用DWI-MRI联合血清AFP诊断小肝癌的特异度、灵敏度和准确度均显著高于单独应用DWI-MRI,或血清AFP(P<0.05)。表明DWI-MRI联合血清AFP对小肝癌的诊断价值显著,可为病情评估提供切实可行的参考。     

基于黑体标定的红外图像非均匀性校正系统设计

为提高某中波红外探测器的图像质量,设计了基于FPGA的红外图像实时处理系统,系统能够完成实时的非均匀性校正与盲元补偿处理。介绍了目前常用的非均匀性校正、盲元识别和补偿算法,并结合实际工程需求采用多点法进行非均匀性校正以及8点平均法进行盲元补偿。在仿真实验成功的基础上,基于FPGA平台构建了硬件平台。系统可以实现系数自定义更新,可以手动或自动完成非均匀性较正系数计算,以及实现盲元列表的自动更新操作。利用某国产中波红外探测器对处理系统进行了测试试验,实验结果表明:校正后图像非均匀性0.3%,盲元率0.001%。系统工作稳定、可靠,图像处理满足实时性和精度要求。     

Scale-space point spread function based framework to boost infrared target detection algorithms

Small target detection is one of the major concern in the development of infrared surveillance systems. Detection algorithms based on Gaussian target modeling have attracted most attention from researchers in this field. However, the lack of accurate target modeling limits the performance of this type of infrared small target detection algorithms. In this paper, signal to clutter ratio (SCR) improvement mechanism based on the matched filter is described in detail and effect of Point Spread Function (PSF) on the intensity and spatial distribution of the target pixels is clarified comprehensively. In the following, a new parametric model for small infrared targets is developed based on the PSF of imaging system which can be considered as a matched filter. Based on this model, a new framework to boost model-based infrared target detection algorithms is presented. In order to show the performance of this new framework, the proposed model is adopted in Laplacian scale-space algorithms which is a well-known algorithm in the small infrared target detection field. Simulation results show that the proposed framework has better detection performance in comparison with the Gaussian one and improves the overall performance of IRST system. By analyzing the performance of the proposed algorithm based on this new framework in a quantitative manner, this new framework shows at least 20% improvement in the output SCR values in comparison with Laplacian of Gaussian (LoG) algorithm.     

CCD抽样对傅里叶变换轮廓术的影响

从傅里叶变换轮廓术(FTP)原理入手,分析了傅里叶变换过程中频谱的产生,给出了CCD像元信号强度及其经抽样后的变形条纹的表达式,得出了变形条纹的傅里叶频谱式,其频谱是原连续函数的频谱在频域内的无限重复,即"频谱岛"。频谱中除了基频外,还产生了二级、三级等的高级频谱。给出了抽样条件及满足抽样条件的方法:当抽样频率与光栅基频的比值m>4时可以恢复物体的面形,反之不能;减小抽样间隔可以使m>4。给出了实验结果:当m=2.0883时,物体面形没有恢复;当m=16.6667时,物体面形得到了恢复。实验结果证明了理论分析的正确性。     

基于小波高频距离像的红外小目标检测

针对远距离复杂背景下红外小目标检测问题,本文提出了一种基于小波高频距离像的方法。该方法首先将处理空间变换到小波域,通过分析残留背景、目标和噪声系数在高频子带的差异,定义基于邻域均值的子带系数表达形式,构造高频子带系数的中心向量,对小波高频图像进行综合形成距离像,得到红外复杂背景的抑制结果。在此基础上,利用恒虚警率算法将单帧背景抑制图像分割成候选目标、残留背景和噪声像素点。最后,在时间域基于目标运动的相关性,利用管道滤波实现红外小目标的最终检测。仿真实验结果表明,相对于经典算法,本文方法可以实现对红外复杂背景的有效抑制,增强目标信号的强度,准确稳定的从红外复杂背景中检测出小目标。     

基于MDARM和VxWorks的小型无人机执行器故障检测方法

由于目前在小型无人机执行器故障诊断中存在着智能化程度较低,容易受到人为因素干扰,从而出现故障漏检等问题,难以满足小型无人机对飞行安全的要求。为此,本文提出一种基于多维数据关联规则挖掘(Multidimensional Data Association Rules Mining: MDARM)和VxWorks操作系统的小型无人机执行器故障诊断方法,通过建立执行器内部传感器测量的温度、压力、流速、力矩等相关变量的历史数据库,并对这些数据进行预处理,以避免带来噪声污染,并利用可测量参数与不可测量参数之间的关联性,建立故障诊断知识库,避免了诊断过程中的人为因素干扰,实现小型无人机执行器故障的精准测量。实验结果证明,这种方法能够有效地提高故障准确率64.7%,对小型无人机执行器的智能诊提供有效指导,应用前景广阔。     

The Activation of Sulfur Hexafluoride at Highly Reduced Low‐Coordinate Nickel Dinitrogen Complexes

The greenhouse gas sulfur hexafluoride is the common standard example in the literature of a very inert inorganic small molecule that is even stable against O₂ in an electric discharge. However, a reduced β‐diketiminate nickel species proved to be capable of converting SF₆ into sulfide and fluoride compounds at ambient standard conditions. The fluoride product complex features an unprecedented [NiF]⁺ unit, where the Ni atom is only three‐coordinate, while the sulfide product exhibits a rare almost linear [Ni(μ‐S)Ni]²⁺ moiety. The reaction was monitored applying ¹H NMR, IR and EPR spectroscopic techniques resulting in the identification of an intermediate nickel complex that gave insight into the mechanism of the eight‐electron reduction of SF₆.