Photochemical Properties and Activity of Water‐Soluble Polymer/C60 Nanohybrids for Photodynamic Therapy

Water‐soluble star‐like poly(vinyl alcohol)/C₆₀ and poly{[poly(ethylene glycol) acrylate]‐co‐(vinyl acetate)}/C₆₀ nanohybrids are prepared by grafting macroradicals onto C₆₀ and are assessed as photosensitizers for photodynamic therapy. The photophysical and biological properties of both nanohybrids highlight key characteristics influencing their overall efficiency. The macromolecular structure (linear/graft) and nature (presence/absence of hydroxyl groups) of the polymeric arms respectively impact the photodynamic activity and the stealthiness of the nanohybrids. The advantages of both nanohybrids are encountered in a third one, poly[(N‐vinylpyrrolidone)‐co‐(vinyl acetate)]/C₆₀, which has linear grafts without hydroxyl groups, and shows a better photodynamic activity.

     

下腔静脉滤网置入术介入治疗双下肢深静脉血栓性静脉炎的护理对策

目的探讨下腔静脉滤网置入术介入治疗双下肢深静脉血栓性静脉炎的护理对策。方法选取佛山市第一人民医院2014年1月至2015年1月期间双下肢深静脉血栓性静脉炎患者65例,全部患者均实施下腔静脉滤网置入术作为介入治疗手段,同时采用综合护理对策。结果 65例双下肢深静脉血栓性静脉炎患者下腔静脉滤网置入术介入治疗一次性成功率为100.00%(65/65),未出现下腔静脉损伤、下腔静脉滤网移位等现象,手术顺利,无并发症出现。术后随访6~12个月发现59例患者经彩色多普勒超声检测均无双下肢深静脉血栓形成,随访期间均未出现下腔静脉滤网倾斜、变形与移位,无并发肺栓塞。结论采用综合护理对策有助于提高下腔静脉滤网置入术介入成功率,提高护理质量。     

基于激光光热法的固体热扩散率数值分析

固体材料的热扩散率对于研究低温非稳态导热过程极为重要,为了研究固体材料在低温下的热扩散率,本文根据热扩散理论模型计算样品材料在不同温度时的热扩散率,在此基础上基于激光光热法对热扩散率与激光频率和相位之间的函数关系进行了数值模拟,数值计算结果与实验数据对比表明两者基本相符,研究表明激光光热法可对固体材料的热扩散率进行有效测量,样品材料在低温下热扩散率的数值模拟表明20～80 K温区样品材料热扩散率随温度变化而显著变化,80～300 K温区材料热扩散率变化较小。     

并行迭代的高阶加速方法

从4阶收敛的并行迭代公式出发,利用并行加速技巧构造了一个5阶收敛的并行迭代算法,并进行了收敛性分析,通过数值实验验证了算法的高速收敛性.     

Enzyme Prodrug Therapy Engineered into Biomaterials

In this work, enzyme‐prodrug therapy (EPT) is engineered into hydrogel biomaterials to achieve localized synthesis of the drugs and their delivery to the adhering cells. The use of EPT in the context of drug delivery mediated by biomaterials significantly empowers the latter in that the same hydrogel is used to successfully synthesize several drugs with dissimilar structures and therapeutic effects. The concentration of the synthesized drugs is conveniently controlled by the concentration of the administered prodrugs. Using prodrugs for two therapeutic agents allows their synthesis and delivery with independent control over the concentration and the time of administration of each of the drugs. Using these tools, sequential delivery of drugs for anti‐inflammatory and anti‐proliferative activity is accomplished whereby the synthesis of drugs is mediated by the same enzyme‐functionalized hydrogel. The use of EPT to perform combination therapy mediated by an implantable biomaterial is also reported. Taken together, these results contribute significantly to the development of flexible and highly powerful tools of substrate‐mediated drug delivery with applications in the design of therapeutic implants and tissue engineering.     

EFPI-FBG hybrid sensor for simultaneous measurement of high temperature and large strain

We report an extrinsic Fabry–Perot interferometer-fiber Bragg grating(EFPI-FBG) hybrid sensor in this letter. The interferometric cavity of the proposed hybrid sensor is composed of a glass capillary tube, a section of single-mode fiber, and a section of single-mode metal fiber with one FBG. The FBG processed by high-temperature annealing is used to measure temperature, whereas the fiber EFPI is adopted for strain measurement. One of the two aligned fibers is free along the axial direction, which is different from the traditional structure that both the fibers are fixed to glass capillary tube. Experimental results show that the sensor can measure high temperature and large strain simultaneously. The measuring range of temperature and strain for the hybrid sensor is up to 500 °C and 10,000 με, respectively. Effective temperature compensation of the hybrid sensor is realized, too.     

相控阵聚焦超声控制系统的设计

低强度聚焦超声治疗技术是当前超声治疗领域的研究热点,应用场景不同对于超声系统的参数和性能要求也具有差异化,相控阵技术的引入为解决聚焦声场精确控制带来了新的思路。现有相控阵聚焦超声控制系统的输出参数相对固定,频率和功率可调范围窄,且支持换能器阵列通道的规模较小。该文设计了一种基于现场可编程逻辑门阵列(FPGA)的256通道的相控阵超声控制系统。实验结果表明,该系统实现频率1~3 MHz 可调,输出电压峰 峰值±100 V连续可调,相位延时精度为5 ns,可驱动不同阵元数的相控阵探头,从而为超声治疗技术的研究提供多元化激励实施方案。