Synthesis,characterization, and application of griseofulvin surface molecularly imprinted polymers as the selective solid phase extraction sorbent in rat plasma samples

In present study, an investigation was carried out to develop and validate an analytical method for the selective extraction and determination of griseofulvin (GSF) from plasma samples. For this purpose, a rational approach was made to synthesize and characterize the surface molecularly imprinted polymers (SMIPs). The SMIPs were utilized as solid phase extraction (SPE) sorbents. The SMIPs were prepared by using GSF as template molecule on the surface of modified silica particles through a non-covalent technique. The particles demonstrated high adsorption capacity (119.1 µg/mL), fast adsorption equilibrium time (30 min) and good recognition selectivity for the template drug. The scanning electron microscopy and infrared spectroscopy were used to explain the structural and morphological characteristics of the SMIPs and surface non-imprinted polymers. The SPE method was combined with HPLC for plasma analysis. The method validation results demonstrated that the established method possessed good linearity for GSF ranging from 0.1 to 50 µg/mL (R² = 0.997). The limit of detection for this method was 0.02 µg/mL for rat plasma samples. The recoveries of GSF from spiked plasma samples were (90.7–97.7%) and relative standard deviations were (0.9–4.5%). Moreover, the SMIPs as selective SPE sorbent can be reused more than 8 times which is a clear advantage over commercial SPE sorbents. Finally, the usefulness of the proposed strategy was assessed by extraction and detection of GSF in real rat plasma samples.     

基于TPS54350型DC/DC变换器的供电系统设计

介绍德州仪器公司推出的内含MOSFET的TPS54350型高效DC-DC变换器的特性及引脚功能.描述TPS54350在某信号处理器供电系统中的应用,给出供电系统的详细设计方案和参考电路,同时也对实际工作中可能出现的问题进行了讨论,供硬件设计者参考.     

四路视频输入处理器SAA7144HL的应用

SAA7144HL是4个单独的多标准视频解码器的组合,是完全的3.3V CMOS电路和高集成的视频监测应用电路.详细介绍了SAA7144HL的内部功能,给出了SAA7144HL的典型应用电路.     

准数字示样DRFM对线性调频脉压雷达的干扰和仿真

传统的干扰信号通过线性调频雷达脉冲压缩处理后,能量损失严重,不能很好的完成干扰的任务.本文简述了DRFM的原理、分类和优缺点,提出准数字示样DRFM的干扰方式,分析这种方式对线性调频脉压雷达干扰的有效性并对此进行仿真.     

基于System Generator的DBF的建模与仿真

简要介绍数字波束形成的基本原理,在此基础上,利用System Generator(SG)进行数字波束形成系统的建模和仿真,并给出仿真结果.     

TMS320DM642多媒体处理系统中高性能音频功能的实现

介绍了在以新一代高性能处理器TMS320DM642为核心的多媒体处理系统中,采用音频编解码芯片TLV320AIC23实现高性能音频处理功能,详细说明了TMS320DM642多路音频串口McASP和内置集成电路总线的软硬件接口设计,并给出了TLV320AIC23初始化设置参数。     

音频媒体矩阵处理器实时备份系统探讨

主要论述了在相关音频系统中,利用音频媒体矩阵处理器进行实时备份时有关的编程方式和技巧,同时表述了作者对如何利用该实时备份系统提高系统安全性的一些观点和建议。     

HFC网络中数字电视信号性能参数测试分析

光纤同轴混合(HFC)网是目前承载数字电视信号的主要传输媒质,HFC网络能否真正满足数字电视传输网络的要求,需要对HFC网络中数字电视信号性能参数进行测试分析.在讨论数字电视信号电平、误码率、调制误差比等主要性能参数的基础上,根据实际运营的有线数字电视HFC网络构建测试模型,测试了数字电视信号的性能参数,分析了数字电视信号在HFC网络中的传输情况.测试分析表明:在目前条件下,HFC网络能适应数字电视信号的传输,有一定的优越性.     

Traps centers and deep defects contribution in current instabilities for AlGaN/GaN HEMT's on silicon and sapphire substrates

AlGaN/GaN high electron mobility transistors (HEMTs) with Si and Al₂O₃ substrates reveals anomalies on I_ds-V_ds-T and I_gs-V_gs-T characteristics (degradation in drain current, kink effect, barrier height fluctuations, etc.). Stress and random telegraph signal (RTS) measurements prove the presence of trap centers responsible for drain current degradation. An explanation of the trapping mechanism responsible for current instabilities is proposed. Deep defects analysis performed by capacitance transient spectroscopy (C-DLTS), frequency dispersion of the output conductance (G_ds(f)), respectively, on gate/source and drain/source contacts and RTS prove the presence of deep defects localized, respectively, in the gate and in the channel regions. Defects detected by C-DLTS and G_ds(f) are strongly correlated, respectively, to barrier height inhomogeneities and kink anomalies. Gate current analysis confirms the presence of (G-R) centers acting like traps at the interface GaN/AlGaN. Finally, the localization of these traps defects is proposed.     

基于CAM的雷达信号实时预分选硬件实现

CAM(内容可寻址存储器)是一种快速匹配存储器件,在通信、雷达等许多领域有着广泛的应用。在介绍CAM基本原理的基础上,例举了一种基于CAM实现关联比较器的设计方法,通过仿真验证了设计的正确性,基本上实现了雷达信号的纯硬件快速预分选,达到了实时性和可靠性要求。