模型药物毒性血清^1H NMR谱代谢组学的Fisher判别分析研究

基于核磁共振技术的代谢组学是近年发展起来的一种新的组学技术,主要利用生物体液的核磁共振谱提供生物体内全部小分子代谢物的丰富信息.然而,噪声的存在影响了模式识别方法分析的准确度.近年来小波变换以其多分辨率分析的特性、方法简单、快速等优点成为一种有效的去除分析信号噪声的方法.本实验通过运用小波变换去除噪声、校正基线后,再进行Fisher判别分析,得到了较传统分析更为清晰的代谢标识物,建立了良好的代谢模型.     

A non-renormalizable B-L model with Q4 × Z4 × Z2 flavor symmetry for cobimaximal neutrino mixing

We construct a non-renormalizable gauge \begin{document}$ B-L $\end{document} model based on \begin{document}$ Q_4\times Z_4\times Z_2 $\end{document} symmetry that successfully explains the cobimaximal lepton mixing scheme. Small active neutrino masses and both neutrino mass hierarchies are produced via the type-I seesaw mechanism at the tree-level. The model is predictive; hence, it reproduces the cobimaximal lepton mixing scheme, and the reactor neutrino mixing angle \begin{document}$ \theta_{13} $\end{document} and the solar neutrino mixing angle \begin{document}$ \theta_{12} $\end{document} can obtain best-fit values from recent experimental data. Our model also predicts the effective neutrino mass parameters of \begin{document}$ m_{\beta }\in (8.80, 9.05)\, \mathrm{meV} $\end{document} and \begin{document}$ \langle m_{ee}\rangle \in (3.65, 3.95)\, \mathrm{meV} $\end{document} for normal ordering (NO) and \begin{document}$ m_{\beta }\in (49.16, 49.21)\, \mathrm{meV} $\end{document} and \begin{document}$ \langle m_{ee}\rangle \in (48.59, 48.67)\, \mathrm{meV} $\end{document} for inverted ordering (IO), which are highly consistent with recent experimental constraints.     

Counterexamples to the well-posedness of transmission boundary value problems for the Laplacian

In this note we show that the well-posedness range for transmission boundary value problems for the Laplacian in the class of Lipschitz domains established by Escauriaza and Mitrea (2004) is sharp. Our approach relies on Mellin transform techniques for singular integrals naturally associated with the transmission problems and on a careful analysis of the spectra of such singular integrals.

     

反潜巡逻机机载雷达扇形搜潜建模与仿真

依据经典的检查搜潜方法,建立反潜巡逻机机载雷达的扇形搜索模型,对其搜潜效率进行了分析。对在不同海况条件、不同经济航速条件和不同搜索面积条件下的搜潜效率进行了仿真。试验结果表明：低海况等级情况下,海况变化对搜潜概率影响不大,但是随着海况等级的增加,搜潜概率急剧下降;随着经济航速的增加,雷达搜潜概率随之降低;随着待搜索海域面积的增加,雷达搜潜概率随之下降。     

On Earthquake Prediction in Japan

Japan’s National Project for Earthquake Prediction has been conducted since 1965 without success. An earthquake prediction should be a short-term prediction based on observable physical phenomena or precursors. The main reason of no success is the failure to capture precursors. Most of the financial resources and manpower of the National Project have been devoted to strengthening the seismographs networks, which are not generally effective for detecting precursors since many of precursors are non-seismic. The precursor research has never been supported appropriately because the project has always been run by a group of seismologists who, in the present author’s view, are mainly interested in securing funds for seismology — on pretense of prediction. After the 1995 Kobe disaster, the project decided to give up short-term prediction and this decision has been further fortified by the 2011 M9 Tohoku Mega-quake. On top of the National Project, there are other government projects, not formally but vaguely related to earthquake prediction, that consume many orders of magnitude more funds. They are also un-interested in short-term prediction. Financially, they are giants and the National Project is a dwarf. Thus, in Japan now, there is practically no support for short-term prediction research. Recently, however, substantial progress has been made in real short-term prediction by scientists of diverse disciplines. Some promising signs are also arising even from cooperation with private sectors.     

Influence of predator mutual interference and prey refuge on Lotka–Volterra predator–prey dynamics

A Lotka–Volterra predator–prey model incorporating a constant number of prey using refuges and mutual interference for predator species is presented. By applying the divergency criterion and theories on exceptional directions and normal sectors, we show that the interior equilibrium is always globally asymptotically stable and two boundary equilibria are both saddle points. Our results indicate that prey refuge has no influence on the coexistence of predator and prey species of the considered model under the effects of mutual interference for predator species, which differently from the conclusion without predator mutual interference, thus improving some known ones. Numerical simulations are performed to illustrate the validity of our results.     

视频数据库多级访问控制

针对视频数据库中涉及敏感信息的视频数据分级保护问题,提出视频数据库多级访问控制模型。在该模型中,设计用户身份辨别及身份强度算法,其结果作为用户安全等级隶属函数的输入,该函数值为用户安全等级隶属度,并与视频数据安全等级隶属度一起作为授权规则中安全等级隶属度比较函数的输入,其函数值结合时间元素能够灵活地实现多级访问控制。与已有的访问控制模型相比,该模型最突出的特点是实现动态授权和视频数据分级保护。     

基于CIE1931的颜色识别方法研究

在国际照明委员会(CIE)的标准协议规定下,通过色彩与波长的对应关系,通过计算斜率,使用线性插值方法计算了颜色所对应的主波长及其饱和度,实现了颜色的辨别,并使用Matlab仿真再现了光谱三刺激值曲线、等能光谱色亮度曲线、舌形色度图。     

New insights into churn prediction in the telecommunication sector: A profit driven data mining approach

Customer churn prediction models aim to indicate the customers with the highest propensity to attrite, allowing to improve the efficiency of customer retention campaigns and to reduce the costs associated with churn. Although cost reduction is their prime objective, churn prediction models are typically evaluated using statistically based performance measures, resulting in suboptimal model selection. Therefore, in the first part of this paper, a novel, profit centric performance measure is developed, by calculating the maximum profit that can be generated by including the optimal fraction of customers with the highest predicted probabilities to attrite in a retention campaign. The novel measure selects the optimal model and fraction of customers to include, yielding a significant increase in profits compared to statistical measures.In the second part an extensive benchmarking experiment is conducted, evaluating various classification techniques applied on eleven real-life data sets from telecom operators worldwide by using both the profit centric and statistically based performance measures. The experimental results show that a small number of variables suffices to predict churn with high accuracy, and that oversampling generally does not improve the performance significantly. Finally, a large group of classifiers is found to yield comparable performance.     

A Padé family of iterations for the matrix sign function and related problems

In this paper we consider the Pad'e family of iterations for computing the matrix sign function and the Padé family of iterations for computing the matrix p‐sector function. We prove that all the iterations of the Padé family for the matrix sign function have a common convergence region. It completes a similar result of Kenney and Laub for half of the Padé family. We show that the iterations of the Padé family for the matrix p‐sector function are well defined in an analogous common region, depending on p. For this purpose we proved that the Padé approximants to the function (1?z)^?σ, 0<σ<1, are a quotient of hypergeometric functions whose poles we have localized. Furthermore we proved that the coefficients of the power expansion of a certain analytic function form a positive sequence and in a special case this sequence has the log‐concavity property. Copyright © 2011 John Wiley & Sons, Ltd.