Optimization of Direct Aromatic 18F-Labeling of Tetrazines

Radiolabeling of tetrazines has gained increasing attention due to their important role in pretargeted imaging or therapy. The most commonly used radionuclide in PET imaging is fluorine-18. For this reason, we have recently developed a method which enables the direct aromatic ¹⁸F-fluorination of tetrazines using stannane precursors through copper-mediated fluorinations. Herein, we further optimized this labeling procedure. 3-(3-fluorophenyl)-1,2,4,5-tetrazine was chosen for this purpose because of its high reactivity and respective limited stability during the labeling process. By optimizing parameters such as elution conditions, precursor amount, catalyst, time or temperature, the radiochemical yield (RCY) could be increased by approximately 30%. These conditions were then applied to optimize the RCY of a recently successfully developed and promising pretargeting imaging agent. This agent could be isolated in a decay corrected RCY of 14 ± 3% and Am of 201 ± 30 GBq/µmol in a synthesis time of 70 min. Consequently, the RCY increased by 27%.     

改进缺陷,套刻和聚焦性能的第五世代浸没式曝光系统

论述了第五世代双扫描平台浸液式扫描曝光机的性能和进展。表明了在高速扫描状态下有生产价值的套刻和聚焦性能的实现。浸液式设备更多的关键部分与缺陷有关,而且该机的改进是通过有生产价值的缺陷水平方面来体现的。为了保持这种缺陷水平的改进效果,需要在圆片应用中进行专门稳定的测量。特加是边缘空泡除去(EBR)设计和圆片斜面良流线性是很重要的。     

非制冷红外焦平面阵列进展

非制冷红外成像技术已广泛应用于军事和民用领域,一直是人们关注的焦点之一,其核心部件是非制冷红外焦平面阵列(IRFPA:Infrared Focal Plane Array)。综述了几种具有代表性的非制冷IRFPA的探测原理、发展历史和现状。它们是:热敏电阻型、热释电型、热电堆型、二极管型、热-电容型非制冷IRFPA和应用光力学效应的非制冷IRFPA、基于法布里-珀罗微腔阵列的非制冷IRFPA。     

SAR stereo imaging algorithm based on Capon spectrum estimation

This letter presents a novel approach for the Synthetic Aperture Radar （SAR） stereo imaging based on the Capon spectrum estimation technique. In order to deal with nonuniform sampling space and lead to super resolution in the elevation direction, Capon approach is used to focus the SAR data on a certain height. Results obtained on simulated data demonstrate the feasibility of the Capon based algorithm. Compared with the classical Fast Fourier Transform （FFT）, the Capon based algorithm shows better resolution quality.     

Simultaneous Activation of Short‐Wave Infrared (SWIR) Light and Paramagnetism by a Functionalized Shell for High Penetration and Spatial Resolution Theranostics

Nanoparticle emitting short‐wave infrared (SWIR) light has received increased attention in the molecular imaging field due to its deeper tissue penetration, fast imaging, high sensitivity, and resolution. The simultaneously activated SWIR excited directly by an 808 nm laser and T₁‐weighted magnetic resonance imaging (MRI) signal are found in one single‐shell nanoparticle NaErF₄@NaGdF₄ (Er@Gd), which is used as a dual‐modality imaging contrast agent in vivo to accurately determine the position of tumors. The conjugated cypate is then aggregated on the surface of Er@Gd@SiO₂‐Cy/bovine serum albumin. With the guidance of dual modality imaging, photothermal therapy is effectively used to ablate tumors in a mouse model. The design of single‐shell nanomaterial activation of SWIR imaging and MRI signals is expected to provide a new strategy for high penetration and spatial resolution cancer theranostics.     

基于STOLT插值聚焦的二维近场微波成像

在弱散射近似回波模型的基础上提出了一个二维近场微波成像算法,用理想金属球的散射回波构造成像系统的点扩散函数,在谱域中剔除测量系统的作用,经Stolt插值聚焦实现波前矫正,用FFT实现目标重构.并对成像算法进行了计算仿真和实验验证,获得了Ku波段金属圆柱和导弹模型的二维近场微波像.     

基于FZP的双焦点聚焦天线的研究

该文基于异于传统的菲涅尔相位修正结构平板(Fresnel Zone Plate),设计并分析了一种具有双焦点结构,可用于毫米波成像等领域的聚焦天线.相比常用的椭球反射蕊天线,新型的FZP天线制作成本低,聚焦性能优越.     

三维快速因式分解后向投影算法

后向投影算法具有精确成像、易于补偿、适于多种阵列构型及信号形式等优点,广泛应用于雷达成像领域。针对三维成像中,巨大计算量带来的低运算效率问题,文中利用孔径分块的方式将二维快速因式分解后向投影（FFBP）扩展至三维成像应用,建立了适于三维FFBP成像的三维极坐标系,对三维FFBP中孔径划分问题、算法实现问题以及计算效率问题进行了分析。仿真结果验证了该算法,其成像效率可提高13.8倍。     

CCD类成像器件的噪声研究

CCD图像传感器的输出信号是空间采样的离散模拟信号,其中夹杂着各种噪声和干扰。对CCD信号进行处理的目的就是在不损失图像细节的前提下,尽可能地消除噪声和干扰,以提高信噪比,获取高质量的图像。为此,必须对CCD的噪声种类和特性有所了解,并针对各种噪声进行相应的去噪处理。所以对CCD成像器件噪声部分的研究,有利于提高CCD成像器件的分辨率,也能提高探测微弱光的能力。     

基于时频分析的合成孔径激光雷达成像算法

建立了SAL回波信号模型,推导计算了微振动对SAL回波相位的影响。分别采用RD算法和基于SPWVD分布的时频成像算法对工作于机载正侧视条带模式的SAL系统进行数值仿真分析。结果表明,在SAL平台作平稳飞行时,采用RD算法可以清晰地对点目标进行成像;根据实际情况引入振动频率不超过500 Hz、振幅不超过0.2 mm的微振动参数,采用RD算法所得到图像的方位分辨率严重下降,采用基于SPWVD分布的时频成像算法可以有效消除振动引起的多普勒频移及其对成像的影响。