Quantitative, dynamic and noninvasive determination of skeletal muscle perfusion in mouse leg by NMR arterial spin-labeled imaging

Because mouse may relatively easily be genetically tailored to develop equivalent of human muscular diseases or to present controlled alterations of mechanisms involved in vasoregulation, it has become the prevalent species to explore such questions. However, the very small size of the animals represents a serious limitation when evaluating the functional consequences of these genetic manipulations. In this context, the recourse to arterial spin labeling (ASL) nuclear magnetic resonance (NMR) methods in which arterial water spins act as an endogenous and freely diffusible tracer of perfusion is tempting but challenging. This article shows that despite the small size of the animal, mouse muscle perfusion may be measured, at rest and in conditions of reactive hyperemia, using saturation inversion recovery sequence, a pulsed ASL variant, combined with NMR imaging. Baseline perfusion values in the mouse leg were 17+/-11 ml.min(-1).100 g(-1) (n=11) and were comparable to microsphere data from the literature. Under ischemia, leg perfusion was 1.2+/-9.3 ml.min(-1).100 g(-1) (n=11). The difference observed between basal and ischemic measurements was statistically different (P=.0001). The temporal pattern of hyperemia in mouse muscle was coherent with previously published measurements in humans and in rats. The mean peak perfusion was 62+/-24 ml.min(-1).100 g(-1) (n=6) occurring 48+/-27 s after the end of occlusion. In conclusion, this study demonstrated the ability of ASL combined to NMR imaging to quantify skeletal muscle perfusion in mice legs, both at rest and dynamically.     

美国ABL计划的新进展

"ABL"系统是一个非常典型的高能激光应用系统,具有高度机动、高度精确及对目标进行闪电打击的特性,以及对多个目标进行毁灭性打击的能力.该系统能适应各种复杂环境,并能以最小的和可恢复的毁伤实现政治、军事上的双赢.因此, "ABL"系统也是美国投入大量人力、物力优先发展的弹道导弹防御武器系统.介绍"ABL"系统的历史、组成及研制分工,详述其近期的技术进展和战场优异性能.     

两个无证书签名方案的分析与改进

无证书密码体制结合了基于身份密码体制和传统公钥密码体制的优点,受到了密码和信息安全研究者的极大关注.对梁景玲等提出的消息可恢复的无证书签名方案和侯红霞等提出的无证书短签名方案进行安全性分析,发现两个方案都不能抵抗公钥替换攻击.通过修改签名者密钥生成算法,增加对用户公钥的有效性验证,提高了梁等方案的安全性.通过在签名阶段将用户公钥绑定进HaSh函数,弥补了侯等方案的安全缺陷.     

扩压器入口面积比对自由旋涡气动窗口性能的影响

针对采用主动式扩压器的自由旋涡气动窗口,实验考察了扩压器入口面积比对扩压器压力恢复性能及自由旋涡气动窗口密封性能的影响。结果表明：入口面积比是影响扩压器压力恢复性能的重要因素;通过优化扩压器入口面积比,可以提高气动窗口密封压比和稳定性。主动式扩压器比传统扩压器具有更小的最佳入口面积比,使气动窗口射流更接近于理想自由旋涡射流;主动式扩压器最佳入口面积比约为2.03。在最佳入口面积比情况下,扩压器内端壁吹气临界驻室压力最低,外端壁吹气压力对密封压力基本没有影响。     

一种基于混沌和汉明码的数字图像篡改检测及修复算法

提出了一种基于混沌映射和汉明码的数字图像篡改检测及修复算法.该算法采用了目前在信道编码中广泛使用的编组码汉明码,将差错控制应用于图像认证和修复,并使用混沌映射保证算法的有效性和安全性.分析及实验表明:该算法在保证良好的视觉效果,嵌入较少认证信息的前提下,可以有效地进行数字图像篡改检测,并能够完成一定程度的图像修复.     

蜂巢蓄热体换热性能的实验研究

实验研究了高温空气燃烧系统使用的蜂巢蓄热体热回收率、最佳换向时间、流动阻力等性能参数及其随几何尺寸的变化规律;提出供风效率的概念,表征流经蓄热体的实际供风量与总供风量的差别,并对热回收率进行了修正。本试验为蓄热体应用与设计提供了依据。     

A balancing method and genetic algorithm for disassembly line balancing

Disassembly activities take place in various recovery operations including remanufacturing, recycling and disposal. The disassembly line is the best choice for automated disassembly of returned products. It is therefore important that the disassembly line be designed and balanced so that it works as efficiently as possible. The disassembly line balancing problem seeks a sequence which: is feasible, minimizes workstations, and ensures similar idle times, as well as other end-of-life specific concerns. However finding the optimal balance is computationally intensive with exhaustive search quickly becoming prohibitively large even for relatively small products. In this paper the problem is mathematically defined and proven NP-complete. Additionally, a new formula for quantifying the level of balancing is proposed. A first-ever set of a priori instances to be used in the evaluation of any disassembly line balancing solution technique is then developed. Finally, a genetic algorithm is presented for obtaining optimal or near-optimal solutions for disassembly line balancing problems and examples are presented to illustrate implementation of the methodology.     

Intensified recovery of valuable products from whey by use of ultrasound in processing steps – A review

The current review focuses on the analysis of different aspects related to intensified recovery of possible valuable products from cheese whey using ultrasound. Ultrasound can be used for process intensification in processing steps such as pre-treatment, ultrafiltration, spray drying and crystallization. The combination of low-frequency, high intensity ultrasound with the pre-heat treatment minimizes the thickening or gelling of protein containing whey solutions. These characteristics of whey after the ultrasound assisted pretreatment helps in improving the efficacy of ultrafiltration used for separation and also helps in preventing the blockage of orifice of spray dryer atomizing device. Further, the heat stability of whey proteins is increased. In the subsequent processing step, use of ultrasound assisted atomization helps to reduce the treatment times as well as yield better quality whey protein concentrate (WPC) powder. After the removal of proteins from the whey, lactose is a major constituent remaining in the solution which can be efficiently recovered by sonocrystallization based on the use of anti-solvent as ethanol. The scale-up parameters to be considered during designing the process for large scale applications are also discussed along with analysis of various reactor designs. Overall, it appears that use of ultrasound can give significant process intensification benefits that can be harnessed even at commercial scale applications.     

基于赝热光照明的单发光学散斑成像

散射介质对光的散射是当前限制光学成像深度或距离的一个严重的问题.本文首先数值模拟比较了光透过随机散射介质成像研究中常用的基于光学记忆效应(memory effect, ME)和自相关(autocorrelation, AC)方法的HIOER算法和乒乓(Ping-Pang, PP)算法的优缺点.通过对HIOER算法和PP算法的恢复效果和迭代次数进行比较,发现PP算法在保持较高恢复效果的前提下拥有更快的运行速度.实验中,利用连续HeNe激光器和旋转毛玻璃产生赝热光源,通过物镜对随机散射介质后数毫米距离内的不同形状物体进行了单帧成像,并采用PP算法成功地恢复出微米量级物体的实际图像.这一研究结果将进一步促进ME和AC方法在深层生物组织医学成像研究上的应用.最后,实验研究了不同的物镜和散射介质的间距对成像恢复的放大率、分辨率和图像强度的影响特性,并进行了详细研究.     

采用泵浦探测技术研究VO2薄膜相变特性

为研究纳秒激光作用下的VO₂薄膜的相变特性,采用泵浦-探测技术进行实验。首先,利用直流磁控溅射法制备VO₂薄膜,经X射线衍射（XRD）和原子力显微镜（AFM）分析表明样品质量较高。然后,测量VO₂薄膜在波长532 nm处的透过率随温度的变化情况,发现透过率随温度升高由32%上升到37%,与红外波段完全相反。在此基础上,选择1 064 nm泵浦光和532 nm探测光研究激光参数中能量密度和重频对VO₂薄膜相变特性的影响,同时结合ANSYS有限元软件对纳秒激光作用下VO₂薄膜的单脉冲温升情况进行分析。结果表明：VO₂薄膜在大于30 mJ/cm²的纳秒激光能量密度作用下,单脉冲温升可达相变温度,最小相变响应时间在14 ns左右。进一步提高纳秒激光能量密度,其相变响应时间略有增加但变化不大。在100 Hz以内改变纳秒激光重频对VO₂薄膜的相变响应基本无影响。VO₂薄膜的相变恢复时间随着纳秒激光能量密度的增大而呈自然指数增加,其变化过程与基底材料和纳秒激光参数密切相关。因此,可以通过优化VO₂薄膜基底材料参数提高其激光防护效果。