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71.
Dmitriy V. Maltsev Alexander A. Spasov Pavel M. Vassiliev Maria O. Skripka Mikhail V. Miroshnikov Andrey N. Kochetkov Nataliya V. Eliseeva Yuliya V. Lifanova Tatyana A. Kuzmenko Lyudmila N. Divaeva Anatolii S. Morkovnik 《Molecules (Basel, Switzerland)》2021,26(19)
A number of novel 2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimidazole derivatives 2 were obtained by alkylation mainly in the 1H-tautomeric form of 2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimidazole or its 8,9-dimethyl-substituted analog 4-chlorobenzyl bromide, 4-chloroacetic acid fluoroanilide, and 4-tert-butylphenacyl bromide in neutral medium. Compounds 3 were cyclized and synthesized earlier with 11-phenacyl-substituted diazepino[1,2-a]benzimidazoles upon heating in conc. HBr. The chemical structures of the compounds were clarified by using the 1H Nuclear Magnetic Resonance Spectroscopy (1H-NMR) technique. Anxiolytic properties were evaluated using the elevated plus maze (EPM) and open field (OF) tests. The analgesic effect of compounds was estimated with the tail flick (TF) and hot plate (HP) methods. Besides, possible the influence of the test compounds on motor activities of the animals was examined by the Grid, Wire, and Rotarod tests. Compounds 2d and 3b were the most active due to their prominent analgesic and anxiolytic potentials, respectively. The results of the performed in silico analysis showed that the high anxiolytic activity of compound 3b is explained by the combination of a pronounced interaction mainly with the benzodiazepine site of the GABAA receptor with a prominent interaction with both the specific and allosteric sites of the 5-HT2A receptor. 相似文献
72.
CDMA直放站引入噪声的分析及对策 总被引:1,自引:0,他引:1
重点分析了噪声对系统产生的影响,并提出了对噪声注入裕量NIN和基站噪声的增加量ROT的折中的相应解决方案. 相似文献
73.
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75.
G. A. V. Ramana Murty G. J. Naga Raju V. Vijayan T. Ranjan Rautray B. Seetharami Reddy S. Lakshminarayana K. L. Narasimham S. Bhuloka Reddy 《Pramana》2004,62(6):1303-1307
The fraction of simultaneous K plus L shell ionized atoms is estimated in Fe, Co and Cu elements using carbon ions at different
projectile energies. The present results indicate that the fraction of simultaneous K plus L shell ionization probability
decreases with increase in projectile energy as well as with increase in the atomic number of the targets atoms. 相似文献
76.
1 IntroductionThedepositofthePostalSavingsBureauinthePeople’sBankofChina (PBC)istheonlywayofuseoffundsthatpostalofficeabsorbsandholdsde positsfromindividuals.Itisaspecialdepositac countanddifferentfrombanker’sreserveaccount,thelatteristhedailyaverageaccountoflegalre servesthatacommercialbankisrequiredtoretainbylawbehinditsdepositsandotherreservableliabil ities[1 ] .OneofthemostdifficulttasksforthePostalSavingsBureauandthePeople’sBankofChinaistopricethedepositsofpostalsavingsinthePeop… 相似文献
77.
影响消光比测试精度的主要因素分析 总被引:5,自引:0,他引:5
介绍了脉冲激光测距机消光比测试系统的功能和结构。对影响脉冲激光测距机消光比测试精度的主要因素逐一进行了分析。结果表明 ,用消光比测试方法考核验收脉冲激光测距机的最大测程和整机测距灵敏度 ,替代现行的在野外对特定目标的实际测距考核和验收 ,有效地克服了气象差异对测量精度的影响和地形条件对测试工作的限制 相似文献
78.
Moira A. McDermott 《Transactions of the American Mathematical Society》2000,352(1):95-114
We consider tight closure, plus closure and Frobenius closure in the rings , where is a field of characteristic and . We use a -grading of these rings to reduce questions about ideals in the quotient rings to questions about ideals in the regular ring . We show that Frobenius closure is the same as tight closure in certain classes of ideals when . Since , we conclude that for these ideals. Using injective modules over the ring , the union of all th roots of elements of , we reduce the question of whether for -graded ideals to the case of -graded irreducible modules. We classify the irreducible -primary -graded ideals. We then show that for most irreducible -primary -graded ideals in , where is a field of characteristic and . Hence for these ideals.
79.
In this paper we generalize the plus-construction given by M. Livernet for algebras over rational differential graded operads to the framework of cofibrant operads over an arbitrary ring (the category of algebras over such operads admits a closed model category structure). We follow the modern approach of J. Berrick and C. Casacuberta defining topological plus-construction as a nullification with respect to a universal acyclic space. We construct a universalH
*Q-acyclic algebra and we define A A+ as the -nullification of the algebra A. This map induces an isomorphism in Quillen homology and quotients out the maximal perfect ideal of 0(A). As an application, we consider for any associative algebra R the plus-constructions of gl(R) in the categories of homotopy Lie and homotopy Leibniz algebras. This gives rise to two new homology theories for associative algebras, namely homotopy cyclic and homotopy Hochschild homologies. Over the rationals these theories coincide with the classical cyclic and Hochschild homologies.Primary: 19D06, 19D55; Secondary: 18D50, 18G55, 55P60, 55U35Received March 2003 相似文献
80.
高能聚变产物与燃料粒子间的核加库仑相干散射 总被引:1,自引:1,他引:0
邓柏权 《核聚变与等离子体物理》2001,21(2):87-93
在具有较高电子温度的D-^3He聚变等离子体中,强子弹性散射、核加库仑相干散射和核反应产物的传播等效尖变得相对重要,而聚变产生的高能离子与电子的库仑相互作用变弱。部分本底燃料离子被聚变产生的高能离子轰击而成为麦克斯韦分布函数尾部的“超热”燃料离子,从而提高了D-^3He聚变反应。 相似文献