Synthesis of iron‐based metal organic framework and its visible light‐driven photocatalytic degradation of dye pollutants

A novel metal–organic compound [Fe (ox)(phen)]_n (phen = 1,10‐Phennannthroline, ox = oxalate acid) has been hydrothermally synthesized and structurally characterized by X‐ray single‐crystal diffraction, X‐ray diffraction, IR, UV–vis diffuse reflectance spectroscopy and X‐ray photoelectron spectroscopy. The compound crystallized in monoclinic,space group P2₁ with a = 0.92289 (3) nm, b = 1.35719 (3) nm, c = 1.02012 (4) nm,β = 94.372 (2)°,V = 1.27402(8)nm³,Z = 2,and exhibited a 2D layer structure. The photocatalytic activities of the compound were evaluated by decomposing Rhodamine B (RhB) and methyl orange (MO) under the visible light irradiation. In addition, the mechanism of the photocatalytic properties were proposed during this process.     

Synthesis and characterization of MgO nanoparticles supported on ionic liquid‐based periodic mesoporous organosilica (MgO@PMO‐IL) as a highly efficient and reusable nanocatalyst for the synthesis of novel spirooxindole‐furan derivatives

The synthesis and catalytic application of a novel MgO containing periodic mesoporous organosilica with ionic liquid framework (MgO@PMO‐IL) is described. The prepared MgO@PMO‐IL was characterized by Fourier transform‐infrared spectroscopy, N₂ adsorption/desorption, transmission electron microscopy, field emission‐scanning electron microscopy, thermogravimetric and inductively coupled plasma analyses. This nanocatalyst was successfully applied as a highly efficient and recoverable catalyst for the synthesis of novel spirooxindole‐furan derivatives via the three‐component reaction of 1,3‐dicarbonyl compounds, N‐phenacyl pyridinium salts and isatin derivatives. The products were achieved in high to excellent yields with a simple work‐up procedure and short reaction times, and the catalyst could be recovered through a simple filtration process and successfully reused seven times without any significant decrease in its efficiency.     

Precise measurement of the micron-scale spot of ultrashort laser pulse based on film scanning

A novel and precise micron-scale nanosecond laser spot measurement based on film-scanning method is presented. The method can be used to measure the spot size, beam profile, and intensity distribution of the pulse.     

Novel Fibers Prepared from Cellulose in NaOH/Urea Aqueous Solution

Summary: Novel regenerated cellulose fibers have been successfully spun from the cellulose dope in NaOH/urea aqueous solution, which could rapidly dissolve cellulose. The fibers possess circular cross‐sections as well as relatively high molecular weight, and a crystallinity index with cellulose II family crystal structure, leading to good mechanical properties. This technology is simple, cheap, and environmentally friendly, promising to substitute for viscose rayon production having hazardous byproducts.

SEM micrograph of the cross‐section of the novel cellulose fibers generated here.     

A novel distributed optic fiber transduser for landslides monitoring

Unstable slopes have been monitored since the beginning of the last century. Current electro-optic detection technology can achieve automatic monitoring remotely with high safety and includes such methods as time domain reflectometry, optical time domain reflectometry and Brillouin optical time domain reflectometry. However, these technologies cannot simultaneously meet the requirements of distributed sensing, high initial measurement accuracy, large sliding distance and high dynamic range. Based on the space frame theory of reinforced concrete beams, this study presents an innovative design for a distributed optic fiber sensor: a novel transduser with a bowknot. Using the optic fiber microbending loss mechanism and optical time domain reflectometry technology, bending and shear tests based on the combined fiber sensor are conducted, and the vertical displacement of midspan, optical fiber sliding distance and loss data under three different spans are collected. Feasibility study and economic analysis of the transduser used for landslide monitoring are also presented. The results show that the maximum sliding distance of our transduser is 21.8, 26.5 and 30.6 mm with corresponding initial accuracies of 1.2, 2.3 and 3.3 mm, and the dynamic ranges are 0-20.6, 0-23.2 and 0-27.3 mm. The cost of the transduser is economical at $0.15/m, which demonstrates promising economic application, high monitoring effectiveness and stability in monitoring civil works, such as slope, dam and tunnel construction and measurement.     

Discovery of Novel Epoxyketone Peptides as Lipase Inhibitors

Obesity is the most common nutritional disorder in the developed world and is associated with important comorbidities. Pancreatic lipase (PL) inhibitors play a key role in the metabolism of human fat. A series of novel epoxyketones peptide derivatives were investigated for their pancreatic lipase inhibitory activity. The epoxyketone moiety is a well-known reactive electrophile group that has been used as part of proteasome inhibitors in cancer therapy, and it is widely believed that these are very selective for targeting the proteasome active site. Here we investigated various peptide derivatives with an epoxide warhead for their anti-lipase activity. The assessment of these novel epoxyketones was performed by an in-house method that we developed for rapid screening and identification of lipase inhibitors using GC-FID. Herein, we present a novel anti-lipase pharmacophore based on epoxyketone peptide derivatives that showed potent anti-lipase activity. Many of these derivatives had comparable or more potent activity than the clinically used lipase inhibitors such as orlistat. In addition, the lipase appears to be inhibited by a wide range of epoxyketone analogues regardless of the configuration of the epoxide in the epoxyketone moiety. The presented data in this study shows the first example of the use of epoxyketone peptides as novel lipase inhibitors.     

用拓扑指数和神经网络研究有机污染物的生物富集因子

在修正Randic的分子连接性指数和连接矩阵的基础上, 定义新型分子连接性指数(mF), 并计算了239种有机污染物的分子连接性指数(mF). 用其1F构建了239种有机污染物生物富集因子(lgBCF)的QSAR模型, 该模型判定系数(R2)及逐一剔除法(LOO)的交互验证系数(Q2)分别为0.747和0.742. 而用1F和4个电性距离矢量(Mk)构建的五元QSAR模型的R2及Q2分别为0.829和0.819. 结果表明, 从统计学的角度, 该模型具有高度的稳定性及良好预测能力. 从此模型可知, 有机污染物BCF的主要影响因素是—C—, ＞C—, —O—, —S—, —X等分子结构碎片以及分子的柔韧性、折叠程度等空间因素. 将5个结构参数作为人工神经网络的输入层结点, 采用5∶26∶1的网络结构, 利用BP算法, 获得了一个令人满意的QSAR模型, 其R2和标准偏差s分别为0.987和0.157, 表明lgBCF与这5个参数具有良好的非线性关系. 从上可见, 新建的连接性指数1F以及电性距离矢量与有机物的生物富集因子具有良好的相关性, 可望在物质构效关系研究中获得广泛的应用.     

Pharmacological Effects and Clinical Prospects of Cepharanthine

Cepharanthine is an active ingredient separated and extracted from Stephania cepharantha Hayata, a Menispermaceae plant. As a bisbenzylisoquinoline alkaloid, cepharanthine has various pharmacological properties, including antioxidant, anti-inflammatory, immunomodulatory, antitumoral, and antiviral effects. Following the emergence of coronavirus disease 2019 (COVID-19), cepharanthine has been found to have excellent anti-COVID-19 activity. In this review, the important physicochemical properties and pharmacological effects of cepharanthine, particularly the antiviral effect, are systematically described. Additionally, the molecular mechanisms and novel dosage formulations for the efficient, safe, and convenient delivery of cepharanthine are summarized.     

一维多重接力COSY和选择性远程DEPT核磁共振技术在新分子骨架生物碱结构测定和谱峰归属研究中的应用

自防已科千金藤根中分得一个新型分子骨架的四氢异喹林类生物碱—excentricine(1)。本工作采用一维多重接力COSY和选择性远程DEPT核磁共振新技术成功地确定谱峰归属,鉴别和连结被季碳和杂原子分割开的自旋体系,测定了其结构。