激光诱导等离子体光谱用于煤中氧的定量分析

利用激光诱导等离子体光谱(LIPS)技术实现对燃煤电厂输煤管中煤质的在线检测对于提高锅炉燃烧效率具有重要的现实意义,但对煤中氧含量的测量却是个难题.提出了一种新的数据处理方法,主要包括内标法、最佳分析线选择法、温度校正法及多线法等,来提高对煤中氧含量定量分析的准确性和重复性.实验中先通过8组煤样获得了煤中氧的定标方程,然后又利用其它6组煤样来验证该定标方程的准确性.实验结果表明,利用本数据处理方法对煤中氧含量测量的绝对误差小于1.1 %,多次测量的相对标准偏差(RSD)小于5.9%,显示了较高的测量精度和重复性.     

Tumor‐Exocytosed Exosome/Aggregation‐Induced Emission Luminogen Hybrid Nanovesicles Facilitate Efficient Tumor Penetration and Photodynamic Therapy

The development of novel photosensitizing agents with aggregation‐induced emission (AIE) properties has fueled significant advances in the field of photodynamic therapy (PDT). An electroporation method was used to prepare tumor‐exocytosed exosome/AIE luminogen (AIEgen) hybrid nanovesicles (DES) that could facilitate efficient tumor penetration. Dexamethasone was then used to normalize vascular function within the tumor microenvironment (TME) to reduce local hypoxia, thereby significantly enhancing the PDT efficacy of DES nanovesicles, and allowing them to effectively inhibit tumor growth. The hybridization of AIEgen and biological tumor‐exocytosed exosomes was achieved for the first time, and combined with PDT approaches by normalizing the intratumoral vasculature as a means of reducing local tissue hypoxia. This work highlights a new approach to the design of AIEgen‐based PDT systems and underscores the potential clinical value of AIEgens.     

确定材料J积分塑性因子η_(pl)的单试件法研究

本文在Ｌａｎｄｅｓ规则化方法基础上提出单试件确定塑性因子法，即只使用单个试件的实验记录Ｐ，Ｖ和ａ就可求得材料塑性因子ηｐｌ．其中实时裂纹长度ａ可以卸载柔度法或物理测量得到．通常规则化方法需一组试件．单试件法可避免多试件存在的尺寸分散性，也可使实验过程简化．文中结合３０４不锈钢实验进行分析，结果表明单试件法简便、实用、精度较高．     

和差幅相不平衡校正与角误差数字化处理

分析了导致和差支路幅相不平衡的原因及幅相不平衡对测角精度的影响。并提供了一种和差支路幅相不平衡数字校正和角误差归一化处理的方法。     

人脸成像特性研究及人脸归一化的目标

探讨了多种输入设备下的人脸成像原理和特征，并基于人脸识别的要求指出了人脸归一化的目标。为了达到这些目标，提出了若干种人脸归一化的方法，并给出了实验结果。     

气相色谱面积归一法测定无水肼组分含量

建立无水肼组分(肼、水、氨)含量分析的气相色谱面积归一法。采用Licp ERC–311弹性石英毛细管柱(30 m×0.53 mm,5.0μm),以热导检测器检测。无水肼样品中水、氨、肼含量测定结果的相对标准偏差分别为0.54%~4.64%,1.15%~2.48%,0.002%~0.030%,与GJB 98–1986测定结果的偏差分别为–0.121 2%~0.007 8%,0.001 3%~0.015 2%,–0.010 0%~0.120 0%,满足标准要求。该法操作简便,自动化程度较高,可代替GJB 98–1986《无水肼》中的分析方法。     

大规模MIMO下最优预编码选择策略研究

大规模多入多出(Massive MIMO)系统中,随着天线数的增加,线性预编码算法的性能逐渐趋于最优,选择合适的线性预编码对系统性能具有重要的意义.针对发射端信道状态信息(Channel State Information at Transmitter,CSIT)不完美的Massive MIMO系统,推导出了迫零(Zero-Forcing,ZF)和最大比传输(Maximum Ratio Transmission,MRT)这两种常见预编码方案在向量归一化方式下的下行可达和速率下界,并给出了证明.随后对两种下界进行了分析,提出了一个关于系统用户数的阈值,当系统用户数和阈值的大小关系不同时,两种预编码性能的优劣关系也不相同.根据分析结果,文章进一步提出了一种以系统中用户数为参量的预编码选择策略,可以保证不论用户数如何变化,系统都能选择出更优的那一个预编码算法来对信号进行预处理.分析的有效性和方案的可靠性通过仿真得到了验证.     

A multilayer screening approach toward the discovery of novel Pf-DHFR inhibitors

A small yet diverse xanthone library was build and computationally docked against wild type Pf-DHFR by Molegro Virtual Docker (MolDock). For analysis of results an integrated approach based on re-ranking, scaling (based on heavy atom counts), pose clustering and visual inspection was implemented. Standard methods such as self-docking (for docking), EF analysis, average rank determinations (for size normalization), and cluster quality indices (for pose clustering) were used for validation of results. Three compounds X5, X113A and X164B displayed contact footprints similar to the known inhibitors with good scores. Finally, 16 compounds were extracted from ZINC data base by similarity based screening, docking score and drug/lead likeness. Out of these 16 compounds, 11 displayed very close contact footprints to experimentally known inhibitors, indicating there potential utility in further drug discovery efforts.     

VBM lesion detection depends on the normalization template: a study using simulated atrophy

Structural neuroimaging studies are of great interest for neuroscientists, which are reflected in the rising number of papers using voxel-based morphometry (VBM). One major step in VBM is the transformation of images to a standard template, a spatial normalization necessary to ensure that homologous regions are compared while interindividual characteristics are maintained. Templates can be created in different ways, and this may affect the likelihood that differences in gray/white matter density between groups are detected. However, studies investigating the interaction of normalization template and VBM accuracy are sparse. Existing work is based on patient–control group comparisons, and the emerging results are inconclusive. The present paper therefore used simulated atrophy in a simplified one-lesion model to systematically study template effects of VBM analyses implemented in SPM. This allowed us to characterize template-specific biases in reference to a set of prespecified parameters of anatomical difference. The data suggest that the likelihood of correctly detecting the prespecified lesion is modulated by the normalization template. Thereby, the relationship between template-related VBM accuracy and specific group/study characteristics is complex, and there does not appear to be one ‘best template.’ Our data show that template effects are critical and clearly suggest that the choice of template needs careful consideration in relation to the specific research question and study constraints.