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针对遗传算法(GA)优化超多参量光学系统时鲁棒性 较差的问题,在混入逃逸函数实数编码GA(MERCGA)的基础上,进一步结合参量归一化和自适 应变异概率的措施,提出了自适应归一化 实数编码GA(ANRCGA)。用ANRCGA对鱼眼镜头光学系统案例进行优化设计,并应用 评价函 数和Zemax光线追迹方法对MERCGA和ANRCGA的优化结果作比较。结果表明,应用本文的ANRCG A 比引自专利的参考设计及MERCGA优化得到光学系统的成像质量有明显提高,算法的鲁棒 性和计算效率也到了改善。 相似文献
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Fabian Benz Christoph Roderburg David Vargas Cardenas Mihael Vucur Jérémie Gautheron Alexander Koch Henning Zimmermann J?rn Janssen Lukas Nieuwenhuijsen Mark Luedde Norbert Frey Frank Tacke Christian Trautwein Tom Luedde 《Experimental & molecular medicine》2013,45(9):e42
MicroRNA (miRNA) levels in serum have recently emerged as potential novel biomarkers for various diseases. miRNAs are routinely measured by standard quantitative real-time PCR (qPCR); however, the high sensitivity of qPCR demands appropriate normalization to correct for nonbiological variation. Presently, RNU6B (U6) is used for data normalization of circulating miRNAs in many studies. However, it was suggested that serum levels of U6 themselves might differ between individuals. Therefore, no consensus has been reached on the best normalization strategy in ‘circulating miRNA''. We analyzed U6 levels as well as levels of spiked-in SV40-RNA in sera of 44 healthy volunteers, 203 intensive care unit patients and 64 patients with liver fibrosis. Levels of U6 demonstrated a high variability in sera of healthy donors, patients with critical illness and liver fibrosis. This high variability could also be confirmed in sera of mice after the cecal ligation and puncture procedure. Most importantly, levels of circulating U6 were significantly upregulated in sera of patients with critical illness and sepsis compared with controls and correlated with established markers of inflammation. In patients with liver fibrosis, U6 levels were significantly downregulated. In contrast, levels of spiked-in SV40 displayed a significantly higher stability both in human cohorts (healthy, critical illness, liver fibrosis) and in mice. Thus, we conclude that U6 levels in the serum are dysregulated in a disease-specific manner. Therefore, U6 should not be used for data normalization of circulating miRNAs in inflammatory diseases and previous studies using this approach should be interpreted with caution. Further studies are warranted to identify specific regulatory processes of U6 levels in sepsis and liver fibrosis. 相似文献
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Shangwang Liu Tongbo Cai Xiufang Tang Yangyang Zhang Changgeng Wang 《Entropy (Basel, Switzerland)》2022,24(1)
Aiming at recognizing small proportion, blurred and complex traffic sign in natural scenes, a traffic sign detection method based on RetinaNet-NeXt is proposed. First, to ensure the quality of dataset, the data were cleaned and enhanced to denoise. Secondly, a novel backbone network ResNeXt was employed to improve the detection accuracy and effection of RetinaNet. Finally, transfer learning and group normalization were adopted to accelerate our network training. Experimental results show that the precision, recall and mAP of our method, compared with the original RetinaNet, are improved by 9.08%, 9.09% and 7.32%, respectively. Our method can be effectively applied to traffic sign detection. 相似文献
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